Navigation Links
Antidepressants during pregnancy linked to preterm birth

BOSTON -- Antidepressant medications taken by pregnant women are associated with increased rates of preterm birth. This finding reinforces the notion that antidepressants should not be used by pregnant women in the absence of a clear need that cannot be met through alternative approaches, say researchers from Brigham and Women's Hospital, Vanderbilt University, MetroWest Medical Center, and Tufts Medical Center.

"Preterm birth is a major clinical problem throughout the world and rates have been increasing over the past two decades. At the same time, rates of antidepressant use during pregnancy have increased approximately four-fold," says lead author Krista Huybrechts, MS PhD, from the Division of Pharmacoepidemiology and Pharmacoeconomics at Brigham and Women's Hospital and Harvard Medical School. "Therefore it is essential to determine what effects these medications have on pregnancy."

Huybrechts and colleagues conducted a systematic review and meta-analysis of published studies that evaluated women who took antidepressants during pregnancy and had information on gestational age at birth. The results appear online in the journal PLOS ONE.

"We studied 41 papers on this topic and found that the available scientific evidence is becoming clearer that antidepressant use in pregnancy is associated with preterm birth," says senior author Adam Urato, MD, a Maternal-Fetal Medicine specialist at Tufts Medical Center and MetroWest Medical Center. "The complication of preterm birth did not appear to be due to the maternal depression but rather it appears likely to be a medication effect."

"Several of the studies in this review controlled for maternal depression and these studies continued to show increased rates of preterm birth in the antidepressant exposed pregnancies," adds Reesha Shah Sanghani MD, MPH, from Vanderbilt University.

"It is important to keep in mind, however, that the issue of treatment of depression during pregnancy is complex and that there are many factors to consider. Pregnant women and their providers need to weigh many issues," says Urato. "It is crucial, though, that the public gets accurate information on this topic."

Rates of preterm birth have been increasing over the past two decades and it is a major public health concern. Children born preterm have higher infant mortality rates than full-term babies and surviving infants are at increased risk of health problems ranging from neurodevelopmental disabilities such as cerebral palsy and intellectual delays to other chronic health problems like asthma. Costs to society have been estimated to be as high as $26.2 billion per year in the US.

Of the 41 studies which the authors reviewed, the majority showed increased rates of preterm birth in patients taking antidepressants. The association was strongest with use in the third trimester. There was no evidence of a beneficial effect or reduction in preterm birth with antidepressant use.

"Preterm birth is the leading cause of infant death and it is also a major contributor to both short and long-term illness," says Urato. "While very preterm infants have the highest risk, we now know that even later preterm birth is associated with significant increases in neonatal morbidity and mortality."

"Pregnant women with depression need proper treatment and our results should not be seen as an argument to ignore depression in these patients," says Huybrechts. "These drugs may be necessary in some pregnant women with severe depression in whom other approaches are inadequate. However, for many others, non-drug treatments, such as psychotherapy, will help, and aren't associated with complications like preterm birth."


Contact: Jeremy Lechan
Tufts Medical Center

Related medicine news :

1. Minorities, Medicare Recipients Less Likely to Get Antidepressants
2. Newer Antidepressants May Be Safe for Parkinsons Patients
3. Publication Bias Casts Doubt on Value of Antidepressants for Autism
4. Medicare Coverage Gap May Cause Seniors to Forgo Antidepressants
5. Common Antidepressants Too Risky During Pregnancy, Researchers Say
6. Common Antidepressants Tied to Higher Bleeding Risk in Warfarin Users: Study
7. When Antidepressants Dont Work, Give Counseling a Try
8. Prenatal Antidepressants Dont Raise Fetal, Infant Death Risk: Study
9. Antidepressants Celexa, Lexapro Tied to Irregular Heartbeat: Study
10. Antidepressants for pregnant moms dont affect infants growth
11. Some Antidepressants Linked to Bleeding Risk With Surgery
Post Your Comments:
(Date:11/30/2015)... ... November 30, 2015 , ... ... four states in the U.S. require dental technicians to be certified or obtain ... industry, NADL created the “What’s In Your Mouth?” campaign to inform dentists that ...
(Date:11/30/2015)... MN (PRWEB) , ... November 30, 2015 , ... ... at . The directory is specialized and only includes chiropractic clinics ... to find a competent and trustworthy alternative health practitioner when back pain sets ...
(Date:11/30/2015)... ... November 30, 2015 , ... ... experience this summer, ushering in a new era of publicly accessible automated technology. ... shuttle, will continue to offer guests an up-close look at the shuttle at ...
(Date:11/30/2015)... (PRWEB) , ... November 30, 2015 , ... ... and fun atmosphere for Halloween festivities, the Word of Life Christian Church of ... board game, and featuring a giant 1.25 ton pile of candy dubbed “Candy ...
(Date:11/30/2015)... (PRWEB) , ... November 30, 2015 , ... ... community across the United States to access life-saving information provided directly ... Mesothelioma will consist of three individual conferences in three major cities: Houston, ...
Breaking Medicine News(10 mins):
(Date:11/30/2015)... 30, 2015 Nevro Corp. (NYSE: NVRO ), ... solutions for the treatment of chronic pain, today announced that ... Patent and Trademark Office (USPTO) has denied instituting an ... (the ,102 patent).  --> ... Scientific Corporation filed two petitions challenging the validity of certain ...
(Date:11/30/2015)... SAN FRANCISCO , Nov. 30, 2015 ... and Designers of Things (DoT ) co-located events ... Printing and the Internet of Things, will draw more ... San Jose Convention Center. The events, combined ... their latest technologies. --> ...
(Date:11/30/2015)... and BOCA RATON, Fla. ... for the Commercialization of Public Research (the Institute) ... with KynderMed , a medical device start-up company ... supports new company creation based on publicly-funded research, and ... Florida -based universities and research institutions. ...
Breaking Medicine Technology: