Navigation Links
Antidepressant and placebo are equally effective in child pain relief
Date:9/30/2009

Bethesda, MD (Oct. 1, 2009) When used "off-label," the antidepressant amitriptyline works just as well as placebo in treating pain-predominant gastrointestinal disorders in children, according to a new study in Gastroenterology, the official journal of the American Gastroenterological Association (AGA) Institute. To view this article's video abstract, go to the AGA's YouTube Channel at www.youtube.com/AmerGastroAssn.

"Many pharmaceutical products are prescribed for off-label use in children due to the lack of clinical trials testing the efficacy of the drugs in children and adolescents. Therefore, the pediatric gastroenterologist frequently has to make treatment decisions without the evidence of how drugs work in children," said Miguel Saps, MD, of Children's Memorial Hospital and lead author of the study. "The high placebo effect we identified in this study suggests that further studies of the use of certain antidepressants in children with functional bowel disorders are needed. While several trials have demonstrated a beneficial effect of antidepressants, including amitriptyline, for the treatment of irritable bowel syndrome (IBS) in adults, more research is needed to determine how effective this drug is, if at all, in children."

Amitriptyline (Elavil) is used to treat symptoms of depression, however, it is often times prescribed to children for pain relief from pain-predominant functional gastrointestinal disorders (FGIDs). Pain-predominant FGIDs are among the most common causes for medical consultation in children. Such disorders include three common conditions: IBS, functional dyspepsia and functional abdominal pain.

Doctors designed a large prospective, multicenter, randomized placebo-controlled trial in which children, ages eight to 17, with IBS, functional abdominal pain or functional dyspepsia were randomized to four weeks of placebo or amitriptyline.

Of the 83 children who completed the study, 63 percent of those who took amitriptyline reported feeling better, while 5 percent reported feeling worse. Of the patients who were given a placebo, 57.5 percent felt better, while 2.5 percent felt worse. Pain relief was excellent (7 percent), good (38 percent) in children on placebo and excellent (15 percent), good (35 percent) in children on amitriptyline. Both amitriptyline and placebo were associated with excellent therapeutic response, although patients with mild to moderate intensity of pain responded better to treatment. There was no significant difference between amitriptyline and placebo after four weeks of treatment.

In children, the use of drugs to treat pain-predominant FGIDs is mostly empirical and based on adult data. There have been only a few small randomized clinical trials evaluating the efficacy of drugs for the treatment of pain-predominant FGIDs in children.


'/>"/>

Contact: Alissa J. Cruz
media@gastro.org
301-272-1603
American Gastroenterological Association
Source:Eurekalert

Related medicine news :

1. Antidepressants Linked to Heart Defects in Newborns
2. Antidepressants: Benefit of SNRI is proven
3. Suicide Risk With Antidepressants Falls With Age
4. Labopharm submits response to FDA for novel antidepressant
5. Antidepressant Use in U.S. Has Almost Doubled
6. Almost 1 quarter of Spanish women take antidepressants
7. Labopharm receives complete response letter from the U.S. FDA for novel antidepressant
8. Antidepressants aid electroconvulsive therapy in treating severe depression
9. Preliminary report on antidepressants published
10. Some Antidepressants May Thwart Tamoxifens Effect on Breast Cancer
11. Results of phase III study on Labopharms novel antidepressant published in Psychiatry (Edgemont) Journal
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/29/2016)... (PRWEB) , ... April 29, 2016 , ... ... and print media enterprise focused entirely on patients with cancer, today announced that ... was chosen as the 2016 CURE® Extraordinary Healer® for Oncology Nursing , ...
(Date:4/29/2016)... ... April 29, 2016 , ... ... outsourced billing and coding services, and Deyta Analytics, recently announced the recipients of ... highest level of quality as measured from the caregiver’s point of view. The ...
(Date:4/29/2016)... (PRWEB) , ... April 29, 2016 , ... Pro3rd Grunge ... Utilize Pixel Film Studios’ lower thirds to introduce people, characters, and locations without having ... include boxes, lines, accents, textures and many more design components. Simply select a preset ...
(Date:4/28/2016)... ... April 29, 2016 , ... Monthly subscription boxes are all the rage, and ... recently reviewed the ZEN BOX , the aromatherapy subscription box. , ZEN BOX delivers ... lavender or frankincense) and one Zen Blend (like immune boost, sublime sleep or de-stress ...
(Date:4/28/2016)... ... 28, 2016 , ... La Sirena Foods provides premium canned seafood, specifically, Tuna, ... looking to grow their market share in the USA. , "We are happy to ... Sirena Foods and indirectly with Otis McAllister , a leading global food ...
Breaking Medicine News(10 mins):
(Date:4/27/2016)... 2016   , ... Recurring Consumable Sales  Clinical sales grow 16% ... (Euronext: MKEA, OTCQX: MKEAY) inventor of Cellvizio®, the multidisciplinary ... the first quarter ended March 31, 2016 and provided ... its commercial strategy. First Quarter 2016 Revenue ...
(Date:4/27/2016)... NORWALK, Conn. , April 27, 2016 /PRNewswire/ ... availability of its digital health technology platform, which ... services and programs into scalable digital products, Zillion ... mobile engagement and empower consumers to take control ... features face-to-face live video conferencing – including one-to-one, ...
(Date:4/27/2016)... April 27, 2016 Shire plc (LSE: ... Poulton , Chief Financial Officer, will present at the Deutsche ... MA on Wednesday, May 04, 2016, 10:00 am ... be available on the Presentations and Webcasts section of Shire,s ... the webcast will be available on this same website for ...
Breaking Medicine Technology: