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Anticancer Drugs Targeting the ErbB (EGFr/HEr2) Pathway Alone Generated Global Sales of Nearly $5 Billion in the First Nine Months of 2007

or phase III (n=43) stages of development. In addition hundreds of agents are in preclinical development. Their mechanisms of action are wide ranging, targeting some of the more than 1,000 different molecular markers implicated in malignancy.

Molecularly targeted agents in development are ushering in the age of personalized medicine. There is pressing need for better diagnostic, theragnostic, prognostic, pharmacogenomic and disease monitoring methodologies for patient selection and optimized treatment.

The source, mechanisms of action, and preclinical and clinical status, including interim and final trial results, of all of these agents are described in detail in New Medicine's Oncology KnowledgeBASE (nm/OK). By interrogating nm/OK users may:

-- Identify novel agents addressing either a single target or multiple

pathways/targets and review in detail their preclinical and clinical


-- Locate targeted agents in clinical trials in combination with specific

approved cytotoxic agents or classes of such drugs, i.e. platinum-based

agents, taxanes, etc.

-- Obtain comprehensive, cited data on over 1,000 targets that may be

applicable as diagnostic, theragnostic, prognostic, pharmacogenomic,

disease monitoring and/or therapeutic targets in cancer

-- Obtain interim and final results of combination trials of approved

anticancer agents, by cancer indication, target, clinical development

status, etc.

-- Obtain detailed records of anticancer targets by 100 different cancer

indications, and many subtypes such as non-small cell lung cancer

(nsclc), triple receptor-negative breast cancer, glioblastoma

multiforme (GBM), etc.

-- View detailed records of drugs in development for several hundred

highly specific clinical indications, i.e. advanced or metastatic

disease, adjuvant or neoadjuvant treatment,

SOURCE New Medicine's Oncology KnowledgeBASE
Copyright©2007 PR Newswire.
All rights reserved

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