Navigation Links
Antibody therapy prevents gastrointestinal damage following radiation exposure in mice

NEW YORK, APRIL 4, 2012 A new study offers the first evidence of a drug capable of preventing lethal damage to the gastrointestinal (GI) tract caused by exposure to high levels of ionizing radiation, such as those occurring during a nuclear incident. There are currently no FDA-approved treatments or prophylactics available to manage the condition, known as radiation gastrointestinal syndrome (RGS), which is associated with weight loss, vomiting, diarrhea, dehydration, systemic infection, and in extreme cases septic shock and death.

The research was conducted in mice by investigators at Memorial Sloan-Kettering Cancer Center and The University of Texas MD Anderson Cancer Center and will be published in the May 2012 issue of The Journal of Clinical Investigation.

The GI system is maintained through the continuous infusion of epithelial cells produced by specialized stem cells located in gland-like structures called crypts found in the epithelial lining of the small intestines and colon. High-dose irradiation kills these stem cells and destroys the protective epithelial barrier, or mucosa, resulting in onset of RGS within days of exposure.

According to the study, administration of a drug called 2A2 anti-ceramide antibody inhibited cell death (apoptosis) in blood vessels within the GI tract and improved 90-day survival from 0 percent to 80 percent among mice exposed to 15 Gy whole-body irradiation.

"We discovered that using this monoclonal antibody to inhibit blood vessel damage and dysfunction led to a dose-dependent increase in the number of surviving stem cells, which are highly active and responsible for repopulation of the damaged GI epithelium," said the study's corresponding author Richard N. Kolesnick, MD, a member of Memorial Sloan-Kettering's Molecular Pharmacology and Chemistry Program whose laboratory conducted the research experiments.

Developed by investigators at MD Anderson, the drug works by interfering with ceramide a lipid molecule that plays a role in apoptosis generated on the surface of the endothelial cells that make up the smallest blood vessels of a tumor.

The US Department of Health and Human Services has placed significant emphasis on the development and deployment of new therapies and countermeasures to protect first responders, military personnel, and others who are required to enter into areas of potential radiation contamination. Dr. Kolesnick and colleagues are working to develop anti-ceramide antibody as an agent used not only to protect against the damaging effects of radiation prior to exposure, but also to mitigate those effects after exposure.


Contact: Esther Napolitano
Memorial Sloan-Kettering Cancer Center

Related medicine news :

1. Antibody treatment protects monkeys from Hendra virus disease
2. Blood Antibody May Signal Start of Ovarian Cancer
3. Specialized regulatory T cell stifles antibody production centers
4. Antibody Finding Might Help in Search for HIV Vaccine
5. Disorderly enzyme is key for antibody diversity
6. Combination antibody therapy shows promise in metastatic melanoma
7. Antibody-guided drug works against acute lymphoblastic leukemia
8. Antibody production gets confused during long-term spaceflight
9. Tiny antibody fragments raised in camels find drug targets in human breast cancer cells
10. Tufts receives patent for antibody treatment against hemolytic uremic syndrome
11. HJF signs distribution agreement for antibody to evaluate prostate cancer
Post Your Comments:
(Date:11/27/2015)... ... 2015 , ... An inventor, from Hopkinsville, Ky., thought there ... home, so he invented the patent-pending ELECTRONIC M.D. , The ELECTRONIC M.D. provides ... so, it could help to prevent potential overdose situations. As a result, it ...
(Date:11/27/2015)... Aliso Viejo, CA (PRWEB) , ... November 27, 2015 , ... ... exclusively for use in Final Cut Pro X. With ProSidebar: Fasion, video editors ... banners, or use ProSidebar as a minimalist title opener. Utilize presets featuring self-animating ...
(Date:11/27/2015)... ... November 27, 2015 , ... A simply groundbreaking television ... an interesting show that delves into an array of issues that are presently affecting ... benefit from open dialogue, this show is changing the subjects consumers focus on, one ...
(Date:11/27/2015)... ... November 27, 2015 , ... The men and ... nonprofit healthcare organizations in the country. They have overseen financial turnarounds, shown commitment ... advance the healthcare industry as a whole through their advocacy and professional efforts. ...
(Date:11/26/2015)... ... November 26, 2015 , ... Patients at Serenity Point ... come together on Thanksgiving Day to share the things that they are most ... Serenity Point YouTube channel, patients displayed what they wrote on index cards, describing ...
Breaking Medicine News(10 mins):
(Date:11/27/2015)... 2015  Lannett Company, Inc. (NYSE: LCI ... acquisition of Kremers Urban Pharmaceuticals Inc. (KU), the ... company UCB S.A. (Euronext: UCB). ... KU from UCB for total consideration of approximately ... customary working capital adjustment, a deduction of certain ...
(Date:11/27/2015)... 26, 2015 ... the "2016 Global Tumor Marker Testing ... and Sales Segment Forecasts, Innovative Technologies, Instrumentation ... to their offering. --> ... "2016 Global Tumor Marker Testing Market: ...
(Date:11/26/2015)... Un nuevo enfoque combina la ... cáncer avanzado.   --> Un nuevo ... Bremachlorin para el cáncer avanzado.   --> ... la terapia fotodinámica de Bremachlorin para el cáncer avanzado. ... --> Clinical Cancer Research . --> ...
Breaking Medicine Technology: