Navigation Links
Antibody therapy prevents gastrointestinal damage following radiation exposure in mice
Date:4/4/2012

NEW YORK, APRIL 4, 2012 A new study offers the first evidence of a drug capable of preventing lethal damage to the gastrointestinal (GI) tract caused by exposure to high levels of ionizing radiation, such as those occurring during a nuclear incident. There are currently no FDA-approved treatments or prophylactics available to manage the condition, known as radiation gastrointestinal syndrome (RGS), which is associated with weight loss, vomiting, diarrhea, dehydration, systemic infection, and in extreme cases septic shock and death.

The research was conducted in mice by investigators at Memorial Sloan-Kettering Cancer Center and The University of Texas MD Anderson Cancer Center and will be published in the May 2012 issue of The Journal of Clinical Investigation.

The GI system is maintained through the continuous infusion of epithelial cells produced by specialized stem cells located in gland-like structures called crypts found in the epithelial lining of the small intestines and colon. High-dose irradiation kills these stem cells and destroys the protective epithelial barrier, or mucosa, resulting in onset of RGS within days of exposure.

According to the study, administration of a drug called 2A2 anti-ceramide antibody inhibited cell death (apoptosis) in blood vessels within the GI tract and improved 90-day survival from 0 percent to 80 percent among mice exposed to 15 Gy whole-body irradiation.

"We discovered that using this monoclonal antibody to inhibit blood vessel damage and dysfunction led to a dose-dependent increase in the number of surviving stem cells, which are highly active and responsible for repopulation of the damaged GI epithelium," said the study's corresponding author Richard N. Kolesnick, MD, a member of Memorial Sloan-Kettering's Molecular Pharmacology and Chemistry Program whose laboratory conducted the research experiments.

Developed by investigators at MD Anderson, the drug works by interfering with ceramide a lipid molecule that plays a role in apoptosis generated on the surface of the endothelial cells that make up the smallest blood vessels of a tumor.

The US Department of Health and Human Services has placed significant emphasis on the development and deployment of new therapies and countermeasures to protect first responders, military personnel, and others who are required to enter into areas of potential radiation contamination. Dr. Kolesnick and colleagues are working to develop anti-ceramide antibody as an agent used not only to protect against the damaging effects of radiation prior to exposure, but also to mitigate those effects after exposure.


'/>"/>

Contact: Esther Napolitano
napolite@mskcc.org
212-639-3573
Memorial Sloan-Kettering Cancer Center
Source:Eurekalert

Related medicine news :

1. Antibody treatment protects monkeys from Hendra virus disease
2. Blood Antibody May Signal Start of Ovarian Cancer
3. Specialized regulatory T cell stifles antibody production centers
4. Antibody Finding Might Help in Search for HIV Vaccine
5. Disorderly enzyme is key for antibody diversity
6. Combination antibody therapy shows promise in metastatic melanoma
7. Antibody-guided drug works against acute lymphoblastic leukemia
8. Antibody production gets confused during long-term spaceflight
9. Tiny antibody fragments raised in camels find drug targets in human breast cancer cells
10. Tufts receives patent for antibody treatment against hemolytic uremic syndrome
11. HJF signs distribution agreement for antibody to evaluate prostate cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/22/2017)... ... 2017 , ... Sideline Products participated in the World Horse Expo held in ... and his production crew. Tom Seay’s program “Best of America by Horseback” is ... Sidekicks will be featured on April 6, 2017. After the broadcast, the clip will ...
(Date:2/22/2017)... ... February 22, 2017 , ... The first-ever National ... organizations, advocates, and individuals join together to increase recognition about the risks of ... lives. , “Today we mark a nationwide movement to raise awareness about a ...
(Date:2/22/2017)... , ... February 22, 2017 , ... ... issues related to spine practices, is featuring Michigan neurosurgeon Jay Jagannathan, M.D., as ... one of a small number of neurosurgeons in Michigan performing minimally invasive back ...
(Date:2/22/2017)... , ... February 22, 2017 , ... ... company, launched a new media platform connecting healthcare technology professionals and other key ... followed by a quarterly publication starting on March 1, announced Michael J. Hennessy, ...
(Date:2/22/2017)... ... February 22, 2017 , ... Super-Sod will attend the Athens Home Show ... Georgia. , A shift from Super-Sod’s simple Athens Home Show booth of 2016, this ... grass seed plant manager Chris Roquemore constructed furniture from recycled pallet wood at the ...
Breaking Medicine News(10 mins):
(Date:2/23/2017)...  CTI BioPharma Corp. (CTI BioPharma) (NASDAQ and MTA: ... fourth quarter and full year 2016 financial results on Thursday, ... financial markets. Following the announcement, members of the management ... the results and provide a general corporate update at 4:30 ... be obtained as follows: Thursday, March 2 ...
(Date:2/22/2017)... N.J. , Feb. 22, 2017  Andre, DiMino, ... technology-based developer and manufacturer of innovative technologies and products, ... results reported on February 21, 2017 in the Company,s ... . ADMT CEO Andre, DiMino stated "During ... our business plan by devoting a larger portion of ...
(Date:2/22/2017)... -- Ultra Clean Holdings, Inc. (Nasdaq: UCTT), a leading ... for the semiconductor capital equipment, flat panel, medical, ... results for the fourth quarter and fiscal year ... a year of extraordinary growth for UCT. Total ... together with continued focus on operational excellence resulted ...
Breaking Medicine Technology: