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Antibody therapy lengthens survival of metastatic melanoma patients in large clinical trial
Date:6/7/2010

rcent of the patients treated with gp100. The complications were generally immune system-related and most often affected the skin and gastrointestinal tract. The most common included diarrhea, nausea, constipation, fatigue, decreased appetite, and rash. While the adverse effects could be severe and long-lasting, most of them were reversible with appropriate treatment, the authors report.

"These findings are very encouraging and will serve as the foundation for future studies," says Hodi. "The next step is to focus on developing combination therapies to develop synergistic and more robust effects as well as incorporating other antibodies that target the same family of molecules."


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Contact: Bill Schaller
william_schaller@dfci.harvard.edu
617-233-5507
Dana-Farber Cancer Institute
Source:Eurekalert

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