Navigation Links
Antibody therapy lengthens survival of metastatic melanoma patients in large clinical trial
Date:6/7/2010

st other cancers. Associated with extended periods of exposure to ultraviolet rays in sunlight, the disease is expected to be diagnosed in more than 68,000 Americans and be responsible for 8,700 deaths in this country in 2010, according to the American Cancer Society. There are no approved therapies for metastatic melanoma beyond standard frontline treatments, and no previous therapy for the disease has been proven effective in a phase III clinical trial.

Ipilimumab, developed by Bristol-Myers Squibb and Medarex, consists of millions of copies of a human antibody that binds to a molecule on T cells white blood cells that patrol the body for signs of illness. The molecule, known as CTLA-4, serves as a control switch for the immune system's response to disease. With no antibody attached, CTLA-4 suppresses the immune response. Ipilimumab reverses that condition, unleashing the immune attack on abnormal cells, including cancer cells. "It essentially takes a brake off the immune system," Hodi says.

The new phase III trial involved 676 patients with advanced (stage III or IV), inoperable melanoma that had worsened during prior therapy for metastatic disease. Patients were randomly assigned to receive one of three treatment regimens: ipilimumab and the gp100 vaccine (which seeks to spark an immune response by presenting the immune system with a protein fragment associated with cancer), ipilimumab alone, or gp 100 alone.

The median survival period for patients receiving ipilimumab plus gp100 was 10 months, compared with 6.4 months for those receiving gp100 alone. The median survival for participants receiving ipilimumab alone was 10.1 months. In the ipilimumab-alone group, nine of 15 patients continued to benefit from the therapy for at least two years, as did four of 23 patients in the combination therapy group.

About 60 percent of the patients treated with ipilimumab experienced adverse side effects to the therapy, as did 32 pe
'/>"/>

Contact: Bill Schaller
william_schaller@dfci.harvard.edu
617-233-5507
Dana-Farber Cancer Institute
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Antibody-guided drug shows encouraging activity in metastatic breast cancer
2. Fox Chase clinical trial tests first of its kind antibody
3. Targeted therapy prolongs life in patients with HER2-positive breast cancer
4. PharmMD Secures Investments to Fund New Opportunities in Medication Therapy Management
5. More smokers kick the habit with extended nicotine patch therapy, Penn research shows
6. Experts Issue Warning on Prostate Hormone Therapy
7. ASGCT: Gene Therapy Shows Promise for Patients with Pompe Disease
8. AAPM statement on quality radiation therapy
9. Congress Urged to Take Immediate Action to Ensure Frail Patients Continue to Receive Critical Therapy Services
10. Intensive Insulin Therapy Wont Boost Septic Shock Survival
11. News brief: Dermatologic infections in cancer patients treated with EGFRI therapy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/9/2014)... 2014 For the first time, researchers have access ... in Canada uses health care. A new study, called ... demonstrate the unique challenges faced by urban Aboriginal people ... Hospital. , The findings, published today in ... Nations individuals and the general population. , Researchers interviewed ...
(Date:7/9/2014)... an innovative tool that captures heretofore hidden ways that ... a protein that makes breast cancer cells more likely ... trigger cancer,s spread in part by blocking two other ... that suggests these two disease processes could have unexpected ... July 10 issue of Nature , points to ...
(Date:7/9/2014)... drug users in Russia might contribute to HIV ... conducted by researchers from Boston University Schools of ... Petersburg Pavlov State University, sought to discover the ... of a cohort of HIV-positive people with lifetime ... arrested by police were more likely to share ...
(Date:7/9/2014)... (July 8, 2014) Researchers from Montefiore Medical ... Medicine of Yeshiva University will present new findings ... July 12 July 17 in Copenhagen, Denmark. Data ... could prompt transition from cognitive normality to mild cognitive ... Einstein Aging Study , established in 1980 to ...
(Date:7/9/2014)... one of the most important organs in the human ... our food properly this is its synthesis function ... organism this is its detoxification function. Lack of ... all damage the liver. The resulting diseased cells can ... life-threatening liver failure. According to the German Liver Foundation, ...
Breaking Medicine News(10 mins):Health News:Urban Aboriginal people face unique health challenges 2Health News:Protein pushes breast cancer cells to metastasize 2Health News:Protein pushes breast cancer cells to metastasize 3Health News:BU researchers relate arrests with HIV risk environment 2Health News:Investigators from Montefiore and Einstein to present data at 2014 Alzheimer's Association International Conference 2Health News:Investigators from Montefiore and Einstein to present data at 2014 Alzheimer's Association International Conference 3Health News:Telemedicine for patients with chronic liver diseases 2Health News:Telemedicine for patients with chronic liver diseases 3
... influenced by advertisements that show horrific consequences of drink-driving ... report . ,The UK Department of ... drink-driving can influence young men not to sit behind ... show that a minimum penalty of a one-year driving ...
... David Beckham has admitted that he is a big softie who ... recently moved to the US after joining LA Galaxy, said that ... while he is watching an upsetting scene in the film. ... we'll be watching a film that's not even upsetting and Victoria ...
... study has suggested that teens indulgence in non-suicidal ... suspected. ,Non-suicidal self-injury is the deliberate, ... intent. ,The findings are important because ... adolescents in the general population than previously thought, ...
... to gain approval from the Food and Drug Administration (FDA), ... Wilson Guthrie, a 61-year-old man from Kansas, suffering from ... home, with that experimental heart-assist device that keeps his heart ... the cardiothoracic ICU has had, and that a lot of ...
... last year in Sierra Leone's capital Freetown last year has ... ,A senior health worker attributed the fall in rabies cases ... Doctors at the main referral Connaught Hospital are worried about ... ,The hospital has had to rely heavily on ...
... who are not graduates of recognised foreign medical schools, ... to practise in Singapore starting next year, the ... from countries like the Philippines, India and Myanmar, have ... Medical Council has allowed institutions to hire them since ...
Cached Medicine News:Health News:Drink-drivers Not Influenced by Ads Unless It Affects Them Personally 2Health News:Self-harming Among Teens More Common Than Thought 2Health News:Self-harming Among Teens More Common Than Thought 3Health News:US Patient Implanted With HeartMate II, Leaves ICU 2
(Date:1/15/2014)... Ill. , Jan. 15, 2014 The Cadence ... Medical Fitness Center by the Medical Fitness Association, a ... to achieve their full potential. The Cadence Fitness & ... the western suburbs and second in the Chicagoland area. ...
(Date:1/15/2014)... NEW YORK , Jan. 15, 2014 ... research report is available in its catalogue: ... & Forecast – Worldwide Analysis ... Pump Market Analysis ...
(Date:1/15/2014)... Quebec , Jan. 15, 2014  Valeant Pharmaceuticals International, ... announced that the applicable waiting period under the Hart-Scott-Rodino ... the previously announced tender offer by its indirect wholly-owned ... outstanding shares of common stock of Solta Medical, Inc. ...
Breaking Medicine Technology:Cadence Fitness & Health Center Certified as Medical Fitness Facility 2Cadence Fitness & Health Center Certified as Medical Fitness Facility 3Insulin Pump Market & Forecast - Worldwide Analysis 2Insulin Pump Market & Forecast - Worldwide Analysis 3Insulin Pump Market & Forecast - Worldwide Analysis 4Insulin Pump Market & Forecast - Worldwide Analysis 5Insulin Pump Market & Forecast - Worldwide Analysis 6Insulin Pump Market & Forecast - Worldwide Analysis 7Insulin Pump Market & Forecast - Worldwide Analysis 8Insulin Pump Market & Forecast - Worldwide Analysis 9Insulin Pump Market & Forecast - Worldwide Analysis 10Insulin Pump Market & Forecast - Worldwide Analysis 11Insulin Pump Market & Forecast - Worldwide Analysis 12Insulin Pump Market & Forecast - Worldwide Analysis 13Insulin Pump Market & Forecast - Worldwide Analysis 14Insulin Pump Market & Forecast - Worldwide Analysis 15Insulin Pump Market & Forecast - Worldwide Analysis 16Insulin Pump Market & Forecast - Worldwide Analysis 17Valeant Pharmaceuticals Announces Receipt Of Antitrust Clearance For Its Previously Announced Acquisition Of Solta Medical, Inc. 2Valeant Pharmaceuticals Announces Receipt Of Antitrust Clearance For Its Previously Announced Acquisition Of Solta Medical, Inc. 3
... (Nasdaq: ENDP ) today announced the successful completion ... West Acquisition Corp., for all of the outstanding shares of ... American Stock Transfer & Trust Company, the depositary for the ... New York City time, on Sept. 17, 2010, the expiration ...
... Products Ltd. announced today that walmart.com is ... is significant because sales velocities are being closely monitored ... retailers dedicate resources to educate and address dysphagia concerns ... crush or grind their meds/supplements and the Power Pill ...
Cached Medicine Technology:Endo Pharmaceuticals Successfully Completes Tender Offer for Shares of Penwest Pharmaceuticals 2Endo Pharmaceuticals Successfully Completes Tender Offer for Shares of Penwest Pharmaceuticals 3Endo Pharmaceuticals Successfully Completes Tender Offer for Shares of Penwest Pharmaceuticals 4VitaCarry(R) Handheld Power Pill Grinder Sales Capturing Retailer's Attention 2
Peribulbar Needle, 25 g. Atkinson style bevel. Overall length 31 mm. 5/box....
Micro Blade tip 6900 style, straight. Dimensions: 15.2 mm x 2.5 mm x 6.2 mm....
Needle Knife, straight, full handle, non-reflective, 0.74 mm width....
Full Handle Laseredge Slit Blade Knife, 3.2 mm angled bevel up. Blade tip dimension: 14.4 mm x 3.2 mm x 3.7 mm....
Medicine Products: