Navigation Links
Antibody leads to repair of myelin sheath in lab study of multiple sclerosis and related disorders
Date:10/9/2007

nal and are especially active at this time. They received a single dose of the antibody. A minimum of 25 mcg/kg was needed to trigger remyelination, which is equivalent to about 2 mg in the average adult, considered a very low dose. The myelin repair plateaued after five weeks in the mice models.

In addition, when combined with daily methylprednisolone, (an immune modulating steroid) the antibody still promotes remyelination in mouse models. This is an important fact because the first multiple sclerosis patients treated with the antibody will have been treated first with methylprednisolone.

As a naturally occurring protein of the immune system, antibodies do not appear to carry any side effects, nor are they toxic -- even when administered at 4,000 times the minimal effective dose -- though the concept has not yet been tested in humans, the researchers say.

In summary, this antibody:

  • Promotes remyelination with a single dose as low as 25 mcg/kg in mice models

  • The remyelination plateaus at five weeks after a single dose

  • Converts a model of chronic immune mediated demyelination to one that repairs with the speed of a toxin induced model of demyelination

In terms of replicating the findings in humans, the researchers have already produced the antibody through genetic engineering and conducted preliminary toxicology experiments in mice showing that 1,000 times the therapeutic dose is not toxic. The study continues to be explored in animal models and eventually, in clinical trials.

In short, the critical finding is that when combined with methylprednisolone, the antibody still effectively promotes remyelination and does not make the mice worse, Dr. Warrington states.


'/>"/>

Contact: Amelyn Reyes
newsbureau@mayo.edu
507-284-5005
Mayo Clinic
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Stroke risk might be linked to antibody
2. Human Antibody That Can Block SARS
3. Therapeutic Monoclonal Antibody Production Is More Profitable Than Small Molecule Drugs
4. Cancer killing antibody effective against prostate cancer
5. Cuba Registers New Antibody
6. Single Sugar Enables Antibody to Treat Inflammation
7. Monoclonal Antibody based system for Anthrax detection
8. Monoclonal Antibody Reduces Exacerbations in Asthmatics
9. Anti-rejection Therapy a Boon for Patients With "anti-donor" Antibody Levels
10. Antibody Therapy Prevents Type 1 Diabetes
11. New Antibody for EGFR Causes Lung Cancer Regression
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/6/2015)... ... July 06, 2015 , ... Invitation to ... yet there is a large gap between the unmet health priorities in the ... health outcomes and reduce unnecessary or ineffective treatments or procedures. , This milestone ...
(Date:7/6/2015)... ... July 06, 2015 , ... The Asian-Pacific market for rheumatoid arthritis therapeutics ... to grow at a CAGR of over 3.2 percent in the years to come ... to be mainly spurred by an anticipated launch of a number of promising pipeline ...
(Date:7/6/2015)... (PRWEB) , ... July 06, 2015 , ... ... proper reimbursement for radiology services and ADVOCATE is leading the transition. ADVOCATE, the ... coding expertise with their Top 10 Tips for ICD-10. The ten tips are ...
(Date:7/6/2015)... ... July 06, 2015 , ... ... southern California, has partnered with Woodbridge Walk-In Urgent Care to offer on-site health ... other serious medical conditions. Screenings are affordable and accurate and run about an ...
(Date:7/6/2015)... ... July 06, 2015 , ... Seedstock today announced Pierre ... address at the 4th Annual Seedstock Sustainable Agriculture Conference – “Innovation and the Small ... , held at the University of California-San Diego, will explore solutions and methodologies that ...
Breaking Medicine News(10 mins):Health News:Columbia Nursing Nairobi Summit: Setting a Clinical Research Agenda for Africa 2Health News:APAC Rheumatoid Arthritis Therapeutics Market to Reach Value of USD 6.9 Billion by 2021, Says GBI Research in Its New Report Now Available at MarketPublishers.com 2Health News:ADVOCATE Takes the Lead to Ensure ICD-10 Success: “Top 10 Tips for ICD-10” 2Health News:Woodbridge Walk-In Offers Affordable Early Detection Health Screenings Through Longevity 2Health News:Seedstock Names Go Green Agriculture Founder and CEO as 2015 Sustainable Agriculture Conference Keynote Speaker 2Health News:Seedstock Names Go Green Agriculture Founder and CEO as 2015 Sustainable Agriculture Conference Keynote Speaker 3Health News:Seedstock Names Go Green Agriculture Founder and CEO as 2015 Sustainable Agriculture Conference Keynote Speaker 4
... other research within the Breast Cancer Initiative, as ... 25 million from the Swedish innovation agency Vinnova. ... centre Create Health, where immunologists, tumour biologists, nanotechnologists, ... "This campaign means that our research can benefit ...
... Mich. Want to keep your boss happy? Smile at ... like you mean it. A new study led by ... fake smile throughout the day worsen their mood and withdraw ... result of cultivating positive thoughts such as a tropical ...
... medical literature on cannabis use and sexual health has ... performance. "Cannabis is the most widely-used illicit drug ... Department of Pharmacology and Toxicology. "It is also often ... of the hazardous effects it may be having on ...
... tifacogin does not appear to improve outcomes of patients ... conducted by researchers from North and South America, Europe, ... benefit in the sCAP subgroup of an earlier trial ... ahead of the print edition of the American Thoracic ...
... when they get home from school? It seems that what ... a lot to do with it. In a study looking ... parents, perception of them, and children,s sedentary behavior, Dr. Jenny ... Nutrition Research at Deakin University in Australia, show that neighborhood ...
... February 22, 2011 -- The portion of the brain responsible ... a new study by researchers from the Hebrew University of ... people as they read words in Braille show activity in ... when sighted readers read. The findings challenge the textbook notion ...
Cached Medicine News:Health News:Novel methods for improved breast cancer survival 2Health News:Study: For a better workday, smile like you mean it 2Health News:Anti-clotting agent does not improve outcomes of patients with severe pneumonia 2Health News:Anti-clotting agent does not improve outcomes of patients with severe pneumonia 3Health News:Poor park planning drives kids indoors 2Health News:Brain doesn't need vision at all in order to 'read' material 2Health News:Brain doesn't need vision at all in order to 'read' material 3
(Date:7/6/2015)... , July 6, 2015  OrthoSpace Ltd. ("OrthoSpace" ... first three patients in its US Investigational Device ... 184 patient randomized, single blinded control study that ... conventional repair or partial repair for the treatment ... InSpace is currently commercially available outside of ...
(Date:7/6/2015)... PARIS , July 6, 2015 ... inventor of Cellvizio®, the multidisciplinary confocal laser endomicroscopy ... Japan,s Ministry of Health, ... Confocal Laser Endomicroscopy solution, the AQ-Flex 19 miniprobe. ... Cellvizio AQ -Flex™ 19 miniprobe is comprised of ...
(Date:7/6/2015)... , June 29, 2015 ... of the "Pharmaceutical Packaging Market in North America ... pharmaceutical packaging market in North America ... the period 2014-2019. International regulations regarding ... drug manufacturers, which in turn fuels adoption of sustainable ...
Breaking Medicine Technology:OrthoSpace Enrolls First Patients in US IDE Study 2Mauna Kea Technologies Receives Regulatory Approval for the AQ-Flex 19 Miniprobe in Japan 2Mauna Kea Technologies Receives Regulatory Approval for the AQ-Flex 19 Miniprobe in Japan 3North American Pharmaceutical Packaging Market 2015-2019 with Amcor, Bemis Healthcare Packaging, MeadWestvaco, Owens-Illinois & West Pharmaceutical Services Dominating 2North American Pharmaceutical Packaging Market 2015-2019 with Amcor, Bemis Healthcare Packaging, MeadWestvaco, Owens-Illinois & West Pharmaceutical Services Dominating 3
... SOUTH SAN FRANCISCO, Calif., Dec. 7, 2011 Rigel ... that Raul Rodriguez, the company,s president and chief operating ... the Oppenheimer 22nd Annual Healthcare Conference in New York ... (Logo: http://photos.prnewswire.com/prnh/20030226/RIGLLOGO ) ...
... (NYSE AMEX: IBIO ) today announced that Jules ... a Managing Director of the Company for at least the ... development activity.  Mr. Musing, formerly a Senior Executive at Johnson ... 2011.  In the course of his career in the Pharmaceutical ...
Cached Medicine Technology:Jules Musing to Lead Business Development Effort 2Jules Musing to Lead Business Development Effort 3
Onyx Liquid Embolic System is a device utilized for the pre-surgical embolization of arteriovenous malformations (AVMs)....
... P2000 Pachymeter [i.e., PalmScan P2000] device ... biometer, which incorporates A-mode pulsed-echo ultrasound,technology, ... accurately measure the corneal thickness (CT) ... PalmScan P2000 includes two software user,interfaces; ...
The Cordis ANGIOGUARD Capture Guidewire is the first embolic protection device shown in clinical testing to achieve a relative stroke reduction of 70% during carotid stenting procedures....
... TOX/See™ is a 1-step, hand-held, point-of-care device for ... in human urine. The TOX/See device can ... abused drugs in 3 to 8 minutes and ... TOX/See cassette is individually packaged to maximize convenience ...
Medicine Products: