Navigation Links
Antibody leads to repair of myelin sheath in lab study of multiple sclerosis and related disorders
Date:10/9/2007

ROCHESTER, Minn. -- Mayo Clinic researchers have found that a human antibody administered in a single low dose in laboratory mouse models can repair myelin, the insulating covering of nerves that when damaged can lead to multiple sclerosis and other disorders of the central nervous system.

The study will be presented on Oct. 9 at the American Neurological Association meeting in Washington, D.C.

The repair of chronic spinal cord injury is seldom modeled in laboratory studies, but it is an important reality for the treatment of humans. The concept of using natural human antibodies to treat disease of this kind has not yet been tested in humans, but these research findings are very promising, says Moses Rodriguez, M.D., a Mayo Clinic neurologist and the studys corresponding author. The findings could eventually lead to new treatments that could limit permanent disability, states Arthur Warrington, Ph.D., a Mayo Clinic scientist and study author.

Myelin repair normally occurs spontaneously, but in multiple sclerosis and other disorders of the central nervous system, the myelin repair process occurs very slowly or fails altogether. Researchers are trying to determine how to speed up the myelin healing process, which they hope will eventually lead to new treatments for patients.

The antibody, which was genetically engineered from a single cell, binds to myelin and the surface of cells in the brain and spinal cord, then it triggers the cells to begin the repair process called remyelination. This antibody is the first known reagent designed to induce repair by acting within the central nervous system at the damage sites on cells responsible for myelin synthesis.

The study uses laboratory mouse models of chronic progressive multiple sclerosis in humans. The severity of the disease and also success of the treatment were largely defined by how naturally active the mice were, particularly during the night because mice are noctur
'/>"/>

Contact: Amelyn Reyes
newsbureau@mayo.edu
507-284-5005
Mayo Clinic
Source:Eurekalert

3

GOOD

Page: 1 2

Related medicine news :

1. Stroke risk might be linked to antibody
2. Human Antibody That Can Block SARS
3. Therapeutic Monoclonal Antibody Production Is More Profitable Than Small Molecule Drugs
4. Cancer killing antibody effective against prostate cancer
5. Cuba Registers New Antibody
6. Single Sugar Enables Antibody to Treat Inflammation
7. Monoclonal Antibody based system for Anthrax detection
8. Monoclonal Antibody Reduces Exacerbations in Asthmatics
9. Anti-rejection Therapy a Boon for Patients With "anti-donor" Antibody Levels
10. Antibody Therapy Prevents Type 1 Diabetes
11. New Antibody for EGFR Causes Lung Cancer Regression
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/22/2012)... Colonoscopies helped doctors detect a high rate of ... screening for the first time, a new study ... be made available to otherwise healthy elderly people ... research fellow at Grand Rapids Medical Education Partners, ... Grand Rapids, Mich., concluded. For the study, ...
(Date:5/22/2012)... Pa. (May 22, 2012) Potentially severe hypersensitivity reactions ... mechanism, resulting from the creation of drug-induced immunogens that ... a study published online by the journal ... AIDS Society . AIDS is published by ... Wolters Kluwer Health . , The study is ...
(Date:5/22/2012)... (HealthDay News) -- Hundreds of thousands of Americans ... potentially life-threatening liver complications over the next few ... evaluated medical insurance claims data and found that ... liver disease in 2008, and estimated that another ... 2015. The risk of developing advanced liver ...
(Date:5/22/2012)... When brain cells start oozing too much of ... disease, the astrocytes that normally nourish and protect them ... is excreted by all neurons, but rates increase with ... blood, oxygen and nutrients to neurons in addition to ... inflamed by excessive amyloid. , Now researchers have ...
(Date:5/22/2012)... of Tropical Medicine, has produced proteins imitating typical parts ... in more efficient diagnostic tests, without the need for ... of Africans contract sleeping sickness. The cause is a ... bite of tsetse flies. First the parasite multiplies in ... It then lodges in organs like heart and kidneys ...
Breaking Medicine News(10 mins):Health News:Colonoscopy May Detect Curable Cancer in Elderly: Study 2Health News:Reactions to HIV drug have autoimmune cause, reports AIDS journal 2Health News:Reactions to HIV drug have autoimmune cause, reports AIDS journal 3Health News:Hepatitis C Causing Liver Damage in Greater Numbers: Study 2Health News:Neuron-nourishing cells appear to retaliate in Alzheimer's 2Health News:Better tests for sleeping sickness 2
... running at double the number of what they were 10 ... high//.,Deaths due to alcoholic liver disease had risen by 39 ... , Office for National Statistics figures compiled for ... alcoholic liver disease last year, compared to 14,400 admissions in ...
... Recent research has revealed that having several older brothers increases ... finding that adds //weight to the idea of a biological ... of Brock University in St Catharines, Canada said, "It's likely ... that there is probably a biological basis for homosexuality." ...
... by residents living near the former VA Tech Peebles ... fire which ripped// through this industrial site in 1999. ... such as eczema, asthma, psoriasis and thyroid irregularities, However ... a link between the illnesses and the factory site ...
... be associated with reduced length of antibiotic treatment for ... ,A biomarker of infection, procalcitonin appeared to ... therapy as compared with other parameters. ,The ... kind, appears in the first issue for July 2006 ...
... of health had stated on Friday that the precedent ... the Klebsiella// outbreak at Durban's Mahatma Gandhi Memorial Hospital, ... ,Thami Mseleku said, “Nobody needs to communicate these ... before 1994. It's (overcrowding and staff shortages) a known ...
... problem to surmount amidst a host of crisis health issues-that ... be left with zilch options to help its people who ... is said to be fast depleting in national referral hospitals. ... over the next couple of months. This is surely a ...
Other Medicine News:Health News:Alcohol-Related Illnesses On The Rise 2Health News:No Clue to Cause of Mystery Illnesses 2Health News:Procalcitonin-Guided Antibiotic Therapy Proved Effective in CAP Cure 2Health News:Procalcitonin-Guided Antibiotic Therapy Proved Effective in CAP Cure 3Health News:Klebsiella Outbreak In Durban Blamed On Staff Shortage & Overcrowding 2
(Date:5/22/2012)... Calif., MAY 22, 2012 ThermoGenesis Corp. (NASDAQ: ... technologies for the processing, storage and administration of cell ... Thailand for its AXP® AutoXpress® Platform (AXP) used for ... expects to initiate commercial activities in the country later ... presence in the region,s cord blood market through our ...
(Date:5/22/2012)... Mass., May 22, 2012  Halo Therapeutics, ... therapeutics for rare fibrotic diseases, announced today ... $1.1 million from 12 not-for-profit foundations serving the ... the funds to expedite the phase 2 ... for Duchenne muscular dystrophy (DMD). HT-100, a ...
(Date:5/22/2012)... 22, 2012  Systech International, a leading provider ... protect product integrity and authenticity, today announced that ... Vice President. Mr. Harty will be ... of Systech,s Cloud Products and Solutions, and aligning ... "Mr. Harty has a unique perspective of ...
Breaking Medicine Technology:ThermoGenesis Announces Axp Approval In Thailand 2ThermoGenesis Announces Axp Approval In Thailand 3Halo Therapeutics Raises $1.1 Million to Expedite Phase 2 Study of HT-100 2Halo Therapeutics Raises $1.1 Million to Expedite Phase 2 Study of HT-100 3David F. Harty Joins Systech International as Vice President 2AEterna Zentaris to Complete Phase 3 Clinical Trial of Macimorelin 28AEZS 130 29 as First Oral Diagnostic Test for Growth Hormone Deficiency 14520 1AEterna Zentaris to Complete Phase 3 Clinical Trial of Macimorelin 28AEZS 130 29 as First Oral Diagnostic Test for Growth Hormone Deficiency 14520 2AEterna Zentaris to Complete Phase 3 Clinical Trial of Macimorelin 28AEZS 130 29 as First Oral Diagnostic Test for Growth Hormone Deficiency 14520 3China Medical Technologies Announces the SFDA Approval for its SPR System 14518 1China Medical Technologies Announces the SFDA Approval for its SPR System 14518 2China Medical Technologies Announces the SFDA Approval for its SPR System 14518 3Talecris Biotherapeutics Receives FDA Approval for PROLASTIN 28R 29 C 5548 1Talecris Biotherapeutics Receives FDA Approval for PROLASTIN 28R 29 C 5548 2Talecris Biotherapeutics Receives FDA Approval for PROLASTIN 28R 29 C 5548 3Talecris Biotherapeutics Receives FDA Approval for PROLASTIN 28R 29 C 5548 4Talecris Biotherapeutics Receives FDA Approval for PROLASTIN 28R 29 C 5548 5
... ATLANTA, March 24 After completing its review ... Data Safety,Monitoring Board (DSMB) has once again recommended ... collectively as the FAME(TM) (Fluocinolone,Acetonide in Diabetic Macular ... change. The trial is studying the use of ...
... treating pediatric acute lymphoblastic,leukemia combined with molecular science ... disease, MEMPHIS, Tenn., March 20 The ... for children with acute,lymphoblastic leukemia (ALL) will be ... research, according to an article,by St. Jude Children,s ...
Other Medicine Technology:DSMB Again Supports Continuation of the Phase III Clinical Trial of Medidur(TM) FA for the Treatment of DME 2DSMB Again Supports Continuation of the Phase III Clinical Trial of Medidur(TM) FA for the Treatment of DME 3Molecular Science Could Further Improve Leukemia Survival, Say St. Jude Researchers 2
Bioceramic orbital implants insert easily into orbital socket and will not cling to surrounding tissue. Improved interconnectivity between pores enhances vascularization. Implants may be easily drill...
...
... perimeters are not restricted to small ... applications. These are full field capable, ... only perimeters you'll ever need to ... possible. They also include the ...
... Gore's EXCLUDER AAA Endoprosthesis is an innovative ... treatment option for patients with abdominal aortic ... durable ePTFE bifurcated graft with an outer ... device flexibility and material durability. The function ...
Medicine Products: