Navigation Links
Antibody-guided drug shows encouraging activity in metastatic breast cancer
Date:12/12/2009

SAN ANTONIO, TXA new antibody-drug compound shrank or halted the growth of metastatic breast tumors in almost half of a group of patients whose HER2-positive cancer had become resistant to standard therapies, according to early data from a multicenter Phase 2 clinical trial led by a Dana-Farber Cancer Institute researcher.

The findings will be presented at the 32nd annual CTRC-AACR San Antonio Breast Cancer Symposium on Saturday, Dec. 12 (Abstract 710, Henry B. Gonzalez Convention Center, Exhibit Hall B, 7-9 a.m. CT).

Ian Krop, MD, PhD, principal investigator of the study, will report that the hybrid agent, called T-DM1, shrank tumors by 30 percent or more in 40 percent of women with confirmed HER2-positive cancers. Another 13 percent had stable disease for at least six months, for a total clinical benefit rate of approximately 53 percent. The median time before the disease progressed was 7.3 months, including both responders and non-responders. Patients received T-DM1 as long as it was effective and well-tolerated. A total of 110 women were enrolled in the study.

T-DM1 is comprised of the cell-killing drug DM1 and is chemically linked to the monoclonal antibody trastuzumab, which selectively binds to the HER2 growth signal receptor, which is highly overexpressed in HER2-positive breast tumors. Approximately 20 percent of breast cancers are HER2-postive.

Trastuzumab, developed by Genentech and sold under the name Herceptin, has markedly improved the treatment of HER2-positive cancer, but resistance to trastuzumab is a significant problem.

"The antibody binds to the HER2 protein on tumor cells and delivers the drug (DM1) selectively to them but not to normal cells," Krop explained. "This allows us to deliver high doses of the chemotherapy directly to tumor cells. And at the same time, the antibody continues to block the HER2 growth signals."

Krop said that one of the unique features of the study is that i
'/>"/>

Contact: Bill Schaller
william_schaller@dfci.harvard.edu
617-632-4090
Dana-Farber Cancer Institute
Source:Eurekalert

Page: 1 2

Related medicine news :

1. New study shows promise in reducing surgical risks associated with surgical bleeding
2. New research shows how chronic stress worsens neurodegenerative disease course
3. Embryonic Human Stem Cells May Help Repair Heart Muscle, Lab Study Shows
4. Circulating fats kill transplanted pancreas cells, study shows
5. New Heart Pump Shows Promise in Trial
6. Novel 3-D cell culture model shows selective tumour uptake of nanoparticles
7. New Survey Shows Americans are Still Concerned About Food Safety, Yet Still Not Smart About What They Like to Eat
8. Australian-led international study shows blood pressure drugs cut death rate in type 2 diabetes
9. Amid Improving Life Expectancy Rates, Risk of Premature Death is Still Significant for Americans, New Study Shows
10. Avocados may help prevent oral cancer, OSU study shows
11. New Poll Shows Public Distrusts Flawed Healthcare Approach Favored by Governor and Speaker in AB 8
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2015)... Atlanta, GA (PRWEB) , ... July 31, 2015 ... ... Medicine Practice, Pediatric Emergency Medicine Practice, and Hospital Medicine Practice, is pleased to ... Practice in a mobile application format available on iPhones, iPads, and Android ...
(Date:7/31/2015)... ... 31, 2015 , ... A family-run business in Grand Rapids, ... sourced all over the world, then manufactured into specific formulations in northern Michigan. ... highest-quality oils in the industry, which we are bringing to consumers at prices ...
(Date:7/31/2015)... ... July 31, 2015 , ... An ... from NBC talked about a woman’s unfortunate experience having cosmetic skin procedures done ... face, which resulted in blistering, swelling, bruising, and pain. This woman’s experience is ...
(Date:7/31/2015)... ... ... Super-Sod wants to participate in planning new home lawns from the ground ... fit for such a goal. Houzz is a social media site that features home ... that spreads home and home garden design ideas when members share their project pictures ...
(Date:7/31/2015)... (PRWEB) , ... July 31, 2015 , ... ... distribution of a wide variety of nutritional and wellness products, announced the addition ... that specializes in massage therapy, active isolated stretching and the prevention and rehabilitation ...
Breaking Medicine News(10 mins):Health News:EB Medicine Launches Mobile Application for Pediatric Emergency Medicine 2Health News:EB Medicine Launches Mobile Application for Pediatric Emergency Medicine 3Health News:Living Pure Essential Oils takes Therepeutic Essential Oil Market by Storm 2Health News:Dermatologists Discuss Rise in Unqualified Practitioners of Cosmetic Dermatology 2Health News:Dermatologists Discuss Rise in Unqualified Practitioners of Cosmetic Dermatology 3Health News:Super-Sod Created a Landscape Profile on Houzz.com for Home Garden Design 2Health News:NPI Welcomes Vincent Aquilino to Board of Directors 2
... Beneficiaries enrolled in Medicare Part D who reached a ... hole" were much less likely to use prescription drugs ... University of Pittsburgh Graduate School of Public Health study. ... of Health Affairs , raise concerns about health ...
... 2, 2009) New research published in the February issue ... shows a warm-up of 15 to 20 minutes with ... substantial increase in proficiency of surgical skills in surgeons of ... both psychomotor and cognitive skills raises surgeons, alertness to a ...
... at Health Budget HearingALBANY, N.Y., Feb. 2 Today, ... Hearing to address three major issues that impact the ... aging New Yorkers: prescription drug access and affordability, ... care."These issues are critical to New Yorkers staying healthy ...
... NEW YORK, Feb. 2 Weight Watchers International, Inc. (NYSE: ... fourth quarter and full year 2008 after the NYSE close ... conference call on March 4th at 5:00 p.m. ET. During ... and Ann Sardini, Chief Financial Officer, will discuss fourth quarter ...
... HOLLAND, Mich., Feb. 2 Hudsonville Ice Cream today,voluntarily ... Whirl Ice Cream,(UPC# 70438 10250 8), which is available ... Market, L&L Food centers and others. , ... that contain nuts that were,processed in the Blakeley, Ga. ...
... 2 /PRNewswire/ -- Kirby Lester, LLC, the ... fully automated technology breakthrough: the KL30 automated dispensing ... is sized and priced for any retail pharmacy or ... prescriptions per day.Kirby Lester introduced the KL30 today at ...
Cached Medicine News:Health News:Seniors in Medicare's doughnut hole decrease use of meds 2Health News:Journal of American College of Surgeons study finds warm-up helps surgeons improve performance 2Health News:AARP Urges Governor to Use Budget to Maintain Quality of Life For Aging New Yorkers 2Health News:AARP Urges Governor to Use Budget to Maintain Quality of Life For Aging New Yorkers 3Health News:Weight Watchers Announces Fourth Quarter and Full Year 2008 Earnings Conference Call 2Health News:Kirby Lester's New KL30: Fully Automated, Compact System for a Fraction of the Cost of a Robotic Dispenser 2Health News:Kirby Lester's New KL30: Fully Automated, Compact System for a Fraction of the Cost of a Robotic Dispenser 3
(Date:7/31/2015)... -- The Physician-Patient Alliance for Health & Safety ... "Surviving Your Hospital Stay: Physician-Patient Alliance for Health ... A sentence was omitted from the release. ... is a member of the National Coalition to Promote ... the National Coalition to Promote Continuous Monitoring of Patients ...
(Date:7/31/2015)... , July 31, 2015 Egalet ... integrated specialty pharmaceutical company focused on developing, manufacturing ... closing of its previously announced underwritten public offering ... a public offering price of $11.25 per share. ... included 1,000,000 shares issued upon the exercise in ...
(Date:7/31/2015)... 31, 2015 Magnaquest, a ... data and cloud computing operators has signed a ... giant for Internet of Things (IoT) related initiative. ... on subscription model.      (Logo: ... striving for business innovations to make healthcare services ...
Breaking Medicine Technology:Egalet Announces Closing of Public Offering of Common Stock and Exercise in Full of Underwriters' Option to Purchase Additional Shares 2Egalet Announces Closing of Public Offering of Common Stock and Exercise in Full of Underwriters' Option to Purchase Additional Shares 3Egalet Announces Closing of Public Offering of Common Stock and Exercise in Full of Underwriters' Option to Purchase Additional Shares 4Magnaquest Signs a POC With a Leading Pharma Giant in Europe to Manage Subscription Management and Billing for Internet of Things (IoT) 2
... 1 The Center for,Translational Molecular Medicine (CTMM) ... and development of new techniques for,the diagnosis and ... nine,projects will receive research funding amounting to a ... a broad spectrum of small and,medium-sized enterprises, major ...
... warmer,the American Heartworm Society (AHS) wants every pet owner ... risk it carries for pets., Although the risk ... mosquito population increases, the AHS recommends year-round,prevention for both ... pet owners will have their pets protected when they ...
Cached Medicine Technology:Dutch Top Institute Allocates 150 Million Euro to R&D Projects Targeting Early Diagnosis and Treatment of Disease 2Mosquito Season Approaching: American Heartworm Society Reminds Pet Owners of Risk 2
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: