Navigation Links
Antibody Linked to Allergies on the Rise
Date:11/13/2010

By Serena Gordon
HealthDay Reporter

SATURDAY, Nov. 13 (HealthDay News) -- It's a common belief that as you get older, your allergy symptoms will wane, but a new study suggests it's possible that even more older people will be experiencing allergies than ever before.

In a nationally representative sample of people, researchers found that IgE antibody levels -- that's the immune system substance that triggers the release of histamine, which then causes the symptoms of allergies like runny nose and watery eyes -- have more than doubled in people older than 55 since the 1970s.

IgE levels don't always directly correlate with the presence of allergies or consistently indicate their severity, but IgE is the main antibody involved in allergies, explained study author Dr. Zachary Jacobs, a fellow in allergy and immunology at Children's Mercy Hospital and Clinic in Kansas City, Mo.

"With IgE levels, it's hard to make an inference for a specific individual, but we're reporting a population trend, and it looks like there's increased allergic sensitization. It looks like Americans have more allergies now than they did 25 or 30 years ago," Jacobs said.

And, he added, "People in their 50s almost certainly have more allergy now than they did 25 or 30 years ago, and more allergists will be needed for the baby boomers."

The findings are to be presented Saturday at the American College of Allergy, Asthma and Immunology annual meeting, in Phoenix.

Jacobs and his colleagues noticed that no one had looked at levels of IgE in the population since the 1970s, when a large study called the Tucson Epidemiological Study was done.

The new study compared data from the Tucson study in the '70s to data from the more recent National Health and Nutrition Examination Survey (NHANES) from 2005 to 2006.

There were 7,398 people enrolled in NHANES, while the Tucson study included 2,743 people. The demographic profiles for the two studies were similar, although there were slightly more young people (under 24) in the NHANES study.

IgE levels, which are measured with a blood test, however, were not always the same. The Tucson study group had higher IgE levels in only one age group -- 6- to 14-year-olds. In all other age groups, the NHANES participants had significantly higher IgE levels.

The difference was most striking in the older age groups. For example, in those aged 55 to 64, IgE levels among NHANES participants were more than double those of the Tucson group.

Jacobs said his researchers didn't think better testing methods could account for this difference. If better tests were a factor, he said, the differences would have stayed the same across the ages, but in the younger group, IgE levels were lower in the NHANES study compared to the Tucson group.

Jacobs said there are numerous factors that could be at play, but all are hypotheses. He said the "hygiene hypothesis" is a popular theory. The hygiene hypothesis essentially means humans are now living in a world that's too clean, even wiping out good bacteria and leaving the immune system to fight off only the most harmless of foreign substances. Another possibility is the potential of global warming, which could be causing higher CO2 levels and more pollen, theoretically contributing to the rise in allergic disease, he said.

Dr. Jennifer Appleyard is chief of allergy and immunology at St. John Hospital and Medical Center in Detroit. She said: "The common wisdom is that IgE production typically drops as you get older. So, to see a general trend like this is surprising."

"IgE reflects much more than just allergy. It can be affected by many things, like smoking, parasitic diseases and eczema. So it's not just affected by or represented by allergy, and levels of IgE aren't directly correlated with severity of disease. But this study's findings are interesting, and definitely bear further evaluation," Appleyard added.

More information

Learn more about allergies from the U.S. National Library of Medicine.

SOURCES: Zachary Jacobs, M.D., fellow, allergy and immunology, Children's Mercy Hospital and Clinic, Kansas City, Mo.; Jennifer Appleyard, M.D., chief, allergy and immunology, St. John Hospital and Medical Center, Detroit; Nov. 13, 2010, presentation, American College of Allergy, Asthma and Immunology annual meeting, Phoenix


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Fox Chase clinical trial tests first of its kind antibody
2. Antibody therapy lengthens survival of metastatic melanoma patients in large clinical trial
3. Molecular pathways linked to sex, age affect outcomes in lung cancer
4. Physical Changes in Brain Linked to Altered Spirituality
5. Migraine Linked to Increased Heart Attack Risk
6. First Gene Variants Linked to Stuttering Discovered
7. Flat Head Syndrome Linked to Developmental Delays
8. Untreated poor vision in elderly linked to dementia, University of Michigan study shows
9. Genetic Mutation Linked to Prostate Cancer in Blacks
10. Sleep More, Lose Weight – Sleeplessness Linked to Obesity
11. Antibodies linked to cardiovascular disease increase in patients with active lupus
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... Milwaukee, WI (PRWEB) , ... October 13, 2017 , ... ... movement in medicine known as “patient engagement.” The patient is doing more than filling ... research partners. , “There is an increasing emphasis in health care and research ...
(Date:10/13/2017)... IL (PRWEB) , ... October 13, 2017 , ... ... which established the certification process to promote standards of excellence for the field ... Symposium, scheduled for March 22 – 25, 2018 in Orlando, Florida at the ...
(Date:10/13/2017)... ... ... Lori R. Somekh, founder of the Law Office of Somekh & ... and special needs planning attorneys. “Membership in ElderCounsel helps our office remain up to ... with elder law attorneys nationwide,” said Somekh. , ElderCounsel was founded ...
(Date:10/13/2017)... ... October 13, 2017 , ... The Visiting Nurse Association (VNA) of Somerset Hills ... specialty vendors and unique items from across the nation, this holiday-themed event will raise ... offered by the VNA. The boutique will be open Saturday, November 4 (10:00 ...
(Date:10/13/2017)... ... October 13, 2017 , ... Yisrayl Hawkins, Pastor and Overseer at The ... the most popular and least understood books in the Holy Scriptures, Revelation. The Book ... have baffled scholars for centuries. Many have tossed it off as mere rubbish, but ...
Breaking Medicine News(10 mins):
(Date:9/27/2017)... 27, 2017  Commended for their devotion to personalized service, ... as number one in the South Florida Business Journal,s 50 ... 5000 yearly list, the national specialty pharmacy has found its ... will soon be honored by SFBJ as the 2017 ... Set to receive his award in October, Bardisa said ...
(Date:9/23/2017)... Sept. 22, 2017 Janssen Biotech, Inc. (Janssen) ... letter from the U.S. Food and Drug Administration (FDA) ... sirukumab for the treatment of moderately to severely active ... clinical data are needed to further evaluate the safety ... active RA. ...
(Date:9/19/2017)... 19, 2017   ZirMed Inc ., a recognized leader ... that it has been ranked #1 by its users for ... Rankings 2017 User Survey. ZirMed was recognized as the top-ranked ... and medical centers over 200 beds and holds one of ... user survey history. ...
Breaking Medicine Technology: