Navigation Links
Antibody Helps Repair MS Nerve Damage
Date:10/10/2007

Promising results in mice need to be repeated in humans, experts say

WEDNESDAY, Oct. 10 (HealthDay News) -- Researchers say they've made new strides in harnessing the body's natural ability to reverse nerve damage wrought by multiple sclerosis.

According to the U.S. team, a single low dose of a human antibody administered to laboratory mice repaired myelin, the protective sheath that covers nerves. Multiple sclerosis wreaks havoc with the nervous system by stripping away this outer covering.

"This is an exciting first step in increasing our knowledge of repair in multiple sclerosis using a unique approach," said Patricia O'Looney, vice president of biomedical research programs at the National Multiple Sclerosis Society (NMSS) in New York City, which helped fund the research.

The findings were presented Tuesday at the annual meeting of the American Neurological Association, in Washington, D.C.

In healthy individuals, damage to myelin repairs itself naturally. But in people with MS and other disorders of the central nervous system, myelin repair occurs either slowly or not at all. As a result, the flow of information between the brain and the rest of the body is impaired, resulting in movement problems.

Some 400,000 people in the United States and 2.5 million people globally have been diagnosed with MS, most of them between the ages of 20 and 50, according to the NMSS.

"The challenge for researchers in trying to get a cure is, how do we repair myelin and restore function?" O'Looney said.

There is some evidence that cells that produce myelin are still present around damaged areas. As O'Looney put it, "The cells are already there, so how do you stimulate them to do what they're supposed to be doing?"

For this study, researchers at the Mayo Clinic in Rochester, Minn., genetically engineered a special antibody, called rHIgM22. This antibody binds to myelin and the surface of cells in the brain and spinal cord, prompting those cells to begin the process of remyelination.

The antibody is the first known compound to spur repair by acting within the central nervous system.

Laboratory mice that received a single dose of the antibody experienced remyelination that plateaued within five weeks.

When combined with a steroid (often prescribed for patients with MS), the antibody continued to promote remyelination, the research team said. Most human patients who might receive the antibody one day in the future will have already been treated with this steroid, they noted.

The antibodies did not appear to have any side effects, even at 4,000 times the minimal effective dose.

The Mayo team will eventually have to replicate the findings in humans before the concept can become an effective therapy, experts say.

"This approach is trying to use a naturally occurring molecule in our body in such a way that it binds to the cell and triggers signals within the cell to begin the repair process," O'Looney said. "This is a very exciting area of research in MS. How do you stimulate natural repair? How do you stimulate cells already there to repair the damage that's done? This is a unique, different way of approaching that, and it seems to be very successful in one of the animal models of MS."

More information

For more on multiple sclerosis, visit the National Multiple Sclerosis Society.



SOURCES: Patricia O'Looney, Ph.D., vice president, biomedical research programs, National Multiple Sclerosis Society, New York City; Oct. 9, 2007, presentation, American Neurological Association annual meeting, Washington, D.C.


'/>"/>
Copyright©2007 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Stroke risk might be linked to antibody
2. Human Antibody That Can Block SARS
3. Therapeutic Monoclonal Antibody Production Is More Profitable Than Small Molecule Drugs
4. Cancer killing antibody effective against prostate cancer
5. Cuba Registers New Antibody
6. Single Sugar Enables Antibody to Treat Inflammation
7. Monoclonal Antibody based system for Anthrax detection
8. Monoclonal Antibody Reduces Exacerbations in Asthmatics
9. Anti-rejection Therapy a Boon for Patients With "anti-donor" Antibody Levels
10. Antibody Therapy Prevents Type 1 Diabetes
11. New Antibody for EGFR Causes Lung Cancer Regression
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... TX (PRWEB) , ... June 25, 2016 , ... Austin ... of the American College of Mohs Surgery and to Dr. Russell Peckham for medical ... and highly effective treatment for skin cancer. The selective fellowship in Mohs Micrographic Surgery ...
(Date:6/25/2016)... ... June 25, 2016 , ... First Choice Emergency Room , the largest ... as the Medical Director of its new Mesquite-Samuell Farm facility. , “We are ... Mesquite location,” said Dr. James M. Muzzarelli, Executive Medical Director of First Choice Emergency ...
(Date:6/25/2016)... ... ... Friday, June 10, Van Mitchell, Secretary of the Maryland Department of Health and Mental ... exemplary accomplishments in worksite health promotion. , The Wellness at Work Awards took place ... BWI Marriott in Linthicum Heights. iHire was one of 42 businesses to receive an ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... Those who ... with these feelings, many turn to unhealthy avenues, such as drug or alcohol abuse, ... Marne, Michigan, has released tools for healthy coping following a traumatic event. , Trauma ...
(Date:6/24/2016)... ... June 24, 2016 , ... The ... in Dallas that it will receive two significant new grants to support its ... PHA marked its 25th anniversary by recognizing patients, medical professionals and scientists for ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... 2016 , , , WHEN: ... 2016 , , , , LOCATION: , , , Online, ... , , EXPERT PANELISTS:  , , , Frost & Sullivan,s Global ... Bird; Senior Industry Analyst, Divyaa Ravishankar and Unmesh Lal, Program Manager ... pharmaceutical industry is witnessing an exceptional era. Several new demand spaces, ...
(Date:6/23/2016)... , June 23, 2016 Revolutionary ... Oticon , industry leaders in advanced audiology ... of Oticon Opn ™, the world,s first internet ... possibilities for IoT devices.      (Photo: ... introduces a number of ,world firsts,: , ...
(Date:6/23/2016)... Research and Markets has announced the addition ... States, China, Japan, Brazil, United Kingdom, Germany, France, Italy, ... Surgical Procedure Volumes: Global ... surgical procedure volume data in a geographic context. The ... of growth drivers and inhibitors, including world population growth, ...
Breaking Medicine Technology: