Navigation Links
Antibody Finding Might Help in Search for HIV Vaccine
Date:7/14/2011

By Randy Dotinga
HealthDay Reporter

THURSDAY, July 14 (HealthDay News) -- Researchers report that they've gained insight into the workings of the immune system's response to HIV, the AIDS virus, in certain people, potentially providing a boost as scientists work toward a vaccine.

The findings won't have an immediate big impact on either vaccine research or HIV treatment. However, they do reveal how soldiers of the immune system known as antibodies use special powers to combat the virus in some patients, said study co-author Dr. Michel C. Nussenzweig, a professor of immunology at The Rockefeller University in New York City.

Ultimately, he said, scientists could develop a vaccine that teaches people's bodies how to make the antibodies. "You'd try to make them do it themselves," he said, instead of pumping antibodies into the body.

Since the late 1990s, AIDS has largely become a treatable, chronic disease. But it can still be deadly, and many scientists think they're years away from developing a vaccine to prevent people from becoming infected in the first place.

In the new study, published online July 14 in Science, researchers focused on antibodies that are produced only in certain patients with HIV. They work by preventing the virus from picking the locks in cells that are supposed to keep germs out.

The problem is that the antibodies don't help cells that have already been infected, Nussenzweig said. And the antibodies only appear about two to three years after someone has been infected with the virus, he said. It's not clear how much the antibodies help those people.

Nussenzweig and colleagues were able to clone the antibodies from four patients. "It's possible that if you were to have enough of these things, there might even be a therapy" for people with the virus, he said. In other words, the antibodies could become part of a drug.

However, the antibodies don't live long, meaning patients would have to undergo repeated and regular treatments if they wanted the protection they may be able to provide, he said. For now, he said, the research seems more likely to help the development of a vaccine.

U.S. National Institutes of Health vaccine researcher Dr. John Mascola said the findings extend "prior work to show that the human immune system can make antibodies that target vulnerable regions of HIV."

Dr. Jonathan D. Fuchs, director of Vaccine Studies at the San Francisco Department of Public Health, said the findings represent an "important advance" because they help define the types of antibodies that vaccines need to elicit in the body.

More information

For more about HIV/AIDS, visit the U.S. National Library of Medicine.

SOURCES: Michel C. Nussenzweig, Ph.D., M.D., professor, immunology, Rockefeller University and Howard Hughes Medical Institute, New York City; John R. Mascola, M.D., Vaccine Research Center, U.S. National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md.; Jonathan D. Fuchs, M.D., M.P.H., director, Vaccine Studies, San Francisco Department of Public Health; July 14, 2011, Science, online


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Disorderly enzyme is key for antibody diversity
2. Combination antibody therapy shows promise in metastatic melanoma
3. Antibody-guided drug works against acute lymphoblastic leukemia
4. Antibody production gets confused during long-term spaceflight
5. Tiny antibody fragments raised in camels find drug targets in human breast cancer cells
6. Tufts receives patent for antibody treatment against hemolytic uremic syndrome
7. HJF signs distribution agreement for antibody to evaluate prostate cancer
8. Antibody Linked to Allergies on the Rise
9. Antibody therapy lengthens survival of metastatic melanoma patients in large clinical trial
10. Fox Chase clinical trial tests first of its kind antibody
11. NIH supports new research strategy for finding a cure for HIV
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Antibody Finding Might Help in Search for HIV Vaccine
(Date:6/25/2016)... ... June 25, 2016 , ... As a lifelong Southern Californian, ... and his M.D from the David Geffen School of Medicine at UCLA. He trained ... Angeles to complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where ...
(Date:6/24/2016)... Angeles, CA (PRWEB) , ... June 24, 2016 , ... ... surgery procedures that most people are unfamiliar with. The article goes on to state ... procedures, but also many of these less common operations such as calf and cheek ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... Sessions in Dallas that it will receive two significant new grants to support ... as PHA marked its 25th anniversary by recognizing patients, medical professionals and scientists ...
(Date:6/24/2016)... ... ... of Topricin and MyPainAway Pain Relief Products, join The ‘Business for a Fair Minimum Wage’ ... 2020 and then adjusting it yearly to increase at the same rate as the median ... floor does not erode again, and make future increases more predictable. , The company is ...
(Date:6/24/2016)... ... June 24, 2016 , ... Puradigm® ... Group (TGIG), has initiated cultivation and processing operations at its production facility, and ... Nevada. , Puradigm is the manufacturer of a complete system of proactive air ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016 Any dentist who has ... of the current process. Many of them do not even ... technical difficulties and high laboratory costs involved. And those who ... it at such a high cost that the majority of ... Dr. Parsa Zadeh , founder of Dental Evolutions ...
(Date:6/23/2016)... June 23, 2016  In a startling report released today, ... residents by lacking a comprehensive, proven plan to eliminate prescription opioid ... ranking of how states are tackling the worst drug crisis in ... states – Kentucky , New Mexico ... . Of the 28 failing states, three – ...
(Date:6/23/2016)... , June 23, 2016 Research ... MEMS Devices Medical Market Analysis 2016 - Forecast to 2022" ... The report contains up to date financial data ... analysis. Assessment of major trends with potential impact on the ... analysis of market segmentation which comprises of sub markets, regional ...
Breaking Medicine Technology: