Navigation Links
Antibodies from the desert as guides to diseased cells
Date:6/12/2014

The use of nanoparticles in cancer research is considered as a promising approach in detecting and fighting tumour cells. The method has, however, often failed because the human immune system recognizes the particles as foreign objects and rejects them before they can fulfil their function. Researchers at the Helmholtz-Zentrum Dresden-Rossendorf (HZDR) and at University College Dublin in Ireland have, along with other partners, developed nanoparticles that not only bypass the body's defence system, but also find their way to the diseased cells. This procedure uses fragments from a particular type of antibody that only occurs in camels and llamas. The small particles were even successful under conditions which are very similar to the situation within potential patients' bodies.

Describing the current state of research, Dr. Kristof Zarschler of the Helmholtz Virtual Institute NanoTracking at the HZDR explains, "At the moment we must overcome three challenges. First, we need to produce the smallest possible nanoparticles. We then need to modify their surface in a way that the proteins in the human bodies do not envelop them, which would thus render them ineffective. In order to ensure, that the particles do their job, we must also somehow program them to find the diseased cells." Therefore, the Dresden and Dublin researchers combined expertise to develop nanoparticles made of silicon dioxide with fragments of camel antibodies.

In contrast to conventional antibodies, which consist of two light and two heavy protein chains, those taken from camels and llamas are less complex and are made up of only two heavy chains. "Due to this simplified structure, they are easier to produce than normal antibodies," explains Zarschler. "We also only need one particular fragment the portion of the molecule that binds to certain cancer cells which makes the production of much smaller nanoparticles possible." By modifying the surface of the nanoparticle, it also gets more difficult for the immune system to recognize the foreign material, which allows the nanoparticles to actually reach their target.

The ultra-small particles should then detect the so-called epidermal growth factor receptor (EGFR) in the human body. In various types of tumours, this molecule is overexpressed and/or exists in a mutated form, which allows the cells to grow and multiply uncontrollably. The Dresden researchers could demonstrate in experiments that nanoparticles that have been combined with the camel antibody fragments can more firmly bind to the cancer cells. "The EGFR is a virtual lock to which our antibody fits like a key," explains Zarschler.

They even obtained the same results in experiments involving human blood serum a biologically relevant environment the scientists point out: "This means that we carried out the tests under conditions that are very similar to the reality of the human body," explains Dr. Holger Stephan, who leads the project. "The problem with many current studies is that artificial conditions are chosen where no disruptive factors exist. While this provides good results, it is ultimately useless because the nanoparticles fail finally in experiments conducted under more complex conditions. In our case, we could at least reduce this error source."

However, more time is required before the nanoparticles can be utilized in diagnosing human tumours. "The successful tests have brought us one step further," explains Stephan. "The road, however, to its clinical use is long." The next aim is to reduce the size of the nanoparticles, which are now approximately fifty nanometres in diameter, to less than ten nanometres. "That would be optimal," according to Zarschler. "Then they would only remain in the human body for a short period just long enough to detect the tumour."
'/>"/>

Contact: Simon Schmitt
s.schmitt@hzdr.de
49-351-260-3400
Helmholtz-Zentrum Dresden-Rossendorf
Source:Eurekalert

Related medicine news :

1. NIH grantees sharpen understanding of antibodies that may cut risk of HIV infection
2. NIH scientists find mechanism that helps HIV evade antibodies, stabilize key proteins
3. Monoclonal Antibodies Market in Gastric and Esophageal Cancers to Reach USD 766 Mln by 2019, Says GBI Research in Its Report Available at MarketPublishers.com
4. Higher mortality in postmenopausal women with RA and anti-CCP antibodies
5. Maine Biotechnology Services-USDA-ARS Partnership Provides Monoclonal Antibodies to Aid in the Containment of Rift Valley Fever Virus
6. Ben-Gurion U. and Sorrento Therapeutics sign agreement to develop anti-hepatitis C virus antibodies
7. Monoclonal Antibodies Market Dealmaking in Biopharma Industry Analyzed in New Research Report at ReportsnReports.com
8. Monoclonal Antibodies Market - New Industry Research Report is Now Available for Pre-Order at Transparency Market Research
9. Research reveals how antibodies neutralize mosquito-borne virus
10. Genetically modified tobacco plants produce antibodies to treat rabies
11. NIH scientists identify protective role for antibodies in Ebola vaccine study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/28/2020)... (PRWEB) , ... May 28, 2020 , ... ... healthcare organization is joining the clinically integrated network (CIN) and the group purchasing ... with AHN’s Cardiovascular Institute to establish a heart failure program at Mon Health ...
(Date:5/28/2020)... ... May 28, 2020 , ... With ... the fall, operators of student housing are scrambling to implement practices that will ... over 37,000 student housing beds on 38 campuses across the country, has researched ...
(Date:5/27/2020)... ... ... The podiatrists and foot doctors of Advanced Foot & Ankle Specialists are ... Arbor Michigan. Dr. Tomasz Biernacki states that “Podiatrists can help support the ... We have been seeing patients in the hospital for the past 3 months, but ...
(Date:5/27/2020)... Ore. (PRWEB) , ... May ... ... May 2020 , Guest: Dr. Gerald Pollack, University of Washington Professor of ... Phase of Water: Beyond Solid, Liquid & Vapor ( https://www.amazon.com/Fourth-Phase-Water-Beyond-Liquid-ebook/dp/B00N2ASKF2 ) , ...
(Date:5/26/2020)... LIVONIA, Mich. (PRWEB) , ... ... ... and RevSpring today announced the availability of two leading RevSpring solutions—Talksoft® patient ... Loyale Patient Payment platform by engaging patients through automated and precise texts, ...
Breaking Medicine News(10 mins):
(Date:5/27/2020)... ENCINITAS, Calif. (PRWEB) , ... May 27, 2020 , ... Hemp Health One’s Giving Away ... free CBD products for the next 60 days. The company is hosting the daily giveaway ... simple. Start by following Hemp Health One’s Instagram page or Hemp Health One’s Facebook page. ...
(Date:5/26/2020)... ... ... Melwood is proud to be donating thousands of vegetable and flowering plants ... and nursing homes. “It’s more important than ever to reach out to those who ... little cheer to seniors and individuals of differing abilities,” said Melwood’s President and CEO, ...
(Date:5/25/2020)... ... , ... Federal data has already confirmed that most of the deadly victims ... failing to report that many of those who have died from the virus were ... new song by an artist that calls himself The Undiscovered Artist brings light to ...
Breaking Medicine Technology: