Navigation Links
Antibiotics can prevent wound complications of childbirth, Stanford/Packard study finds
Date:6/9/2008

STANFORD, Calif. - A single dose of antibiotics can significantly aid healing of the severe tearing that occurs in vaginal tissues during many births, according to researchers at Lucile Packard Children's Hospital at Stanford, the Stanford University School of Medicine and Santa Clara Valley Medical Center. The study is the first to show that the simple treatment can prevent many of the short- and long-term repercussions of this relatively common complication of childbirth.

As many as one in five women suffer severe vaginal tears during childbirth. In the study, those who received the antibiotic endured roughly one-third as many infections or other wound-healing complications two weeks after surgical repair of their tears.

"Recovery from these tears can be painful and problematic," said Packard Children's obstetrician Yasser El-Sayed, MD, associate professor of obstetrics and gynecology and associate chief of maternal-fetal medicine at the School of Medicine. "If you add an infection, or a breakdown of the surrounding tissues, it's a huge burden on the emotional and physical well-being of a new mother."

El-Sayed and Kay Daniels, MD, clinical associate professor of obstetrics and gynecology at the School of Medicine, are co-authors of the research, which is published in the June issue of Obstetrics and Gynecology. Neena Duggal, MD, from Santa Clara Valley Medical Center, is the lead author of the study. The study is accompanied by an editorial in the same journal.

"This is very important news that will likely change obstetrical practice nationwide," said Maurice Druzin, MD, chief of obstetrics and gynecology at Packard Children's and the Charles B. and Ann L. Johnson Professor in the School of Medicine.

Vaginal tears, which occur between the vagina and the anus, are classified in severity according to their length. Third-degree tears extend into the muscle of the anal sphincter and fourth-degree tears reach the rectum. The tears are surgically repaired immediately after delivery but subsequent infections and poor healing that sometimes occur can have lifelong consequences, including incontinence of stool or gas and sexual dysfunction.

Duggal, Daniels and El-Sayed conducted a randomized, double-blind study in 147 women who experienced third- or fourth-degree tears while delivering infants at either Packard Children's Hospital or Santa Clara Valley Medical Center. After agreeing to participate in the study, the women were randomly assigned to receive a one-time intravenous infusion of either antibiotic or placebo during the repair of their tear. Neither the women nor their physicians knew which treatment they received.

The researchers found that four of 49 patients (8.2 percent) treated with antibiotics and 14 of 58 patients (24.1 percent) who received the placebo showed symptoms of infection or breakdown two weeks after the repair. The remaining 40 women did not return for their scheduled follow-up appointments, but the difference between the two returning groups was statistically significant.

"We're excited because it's such a simple intervention," said El-Sayed. The difference between the two groups persisted despite variability in surgical technique, suture and type of antibiotic.

Although the study was relatively small, the results detected an important difference in outcome. Until now, physicians were divided as to whether antibiotic treatment was helpful for these women, and most health-care providers made their own choices.

"At Packard," said El-Sayed, "antibiotic use was pretty hit-or-miss according to the preference of the physician. Personally, I didn't use it. But I certainly do now." Physicians at Packard Children's now routinely use antibiotics when repairing these types of tears.


'/>"/>

Contact: Krista Conger
kristac@stanford.edu
650-725-5371
Stanford University Medical Center
Source:Eurekalert

Related medicine news :

1. When Are Antibiotics for Lyme Disease Medically Necessary?
2. Salmonella in garden birds responsive to antibiotics
3. Sugar-coated antibiotics
4. Gator Blood May Be New Source of Antibiotics
5. Green Tea Boosts Antibiotics for Superbugs
6. Dont Prescribe Antibiotics for Adult Sinus Woes
7. Synthetic peptoids hold forth promise for new antibiotics
8. Biannual Antibiotics May Cut Major Cause of Blindness in Africa
9. Antibiotics Do Little for Inner Ear Infections
10. DNA with a twist: New company to search for cancer drugs and antibiotics
11. Advanced Life Sciences to Participate in Antibiotics Expert Panel at the 10th Annual BIO CEO & Investor Conference
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... Global Healthcare Management’s 4th Annual Kids Fun Run ... This free event, sponsored by Global Healthcare Management’s CEO, Jon Letko, is aimed ... geared towards children of all ages; it is a non-competitive, non-timed event, which is ...
(Date:10/13/2017)... ... October 13, 2017 , ... ... giving viewers the lowdown on sciatica in a new episode of "Success Files," ... on current events and innovation and investigates each subject in-depth with passion and ...
(Date:10/13/2017)... ... ... Journey: From the Mountains to the Mission Field”: the story of a missionary couple ... From the Mountains to the Mission Field” is the creation of published author, Carole ... and currently teaches a class of ladies at her church, which she has taught ...
(Date:10/12/2017)... ... October 12, 2017 , ... First Healthcare Compliance (FHC), ... will showcase a range of technology and learning solutions at the 68th Annual ... Expo to be held October 14–18, 2017 at the Mandalay Bay Resort in ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... Planet Fitness, ... the U.S., announced today its plans to open a flagship location in Covington, LA ... the former Rooms To Go store next to Office Depot in the Holiday Square ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... ORLANDO, Fla. , Oct. 2, 2017  AllianceRx ... services company formed by Walgreens and pharmacy benefit manager ... of its new brand, which included the unveiling of ... Fla. , as well as at a few ... introduces the new brand to patients, some of whom ...
(Date:9/28/2017)... Cohen Veterans Bioscience and Early Signal Foundation ... and home sensors for real-time monitoring of patients with ... nonprofit organization focused on disruptive health solutions for rare ... system to record and integrate behavioral, cognitive, physiological and ... ...
(Date:9/25/2017)... 2017  EpiVax, Inc., a leader in the ... today announced the launch of EpiVax Oncology Inc., ... therapeutic cancer vaccines. EpiVax has provided $500,000 in ... enabling technologies to the new precision immunotherapy venture. ... Oncology as Chief Executive Officer. Gad brings over ...
Breaking Medicine Technology: