Navigation Links
Antibiotics Largest Cause of Drug-Induced Liver Damage
Date:12/1/2008

Prescription meds, supplements can also trigger acute organ failure, study says

MONDAY, Dec. 1 (HealthDay News) -- Antibiotics are the single largest class of drugs that cause idiosyncratic drug-induced liver injury (DILI), researchers say.

The condition accounts for about 13 percent of cases of acute liver failure in the United States and is the most common cause of death from acute liver failure.

DILI is caused by a wide range of prescription and nonprescription medications, nutritional supplements and herbal products. In a new study, Indiana University School of Medicine researchers looked at patients with suspected DILI and found that 73 percent of cases were caused by a single prescription medication, 9 percent by dietary supplements, and 18 percent by multiple agents. Patients with acetaminophen-related liver damage weren't included in the study.

Lead author Dr. Naga P. Chalasani and colleagues found that more than 100 different agents were associated with DILI and that antibiotics (45.5 percent) and nervous system agents (15 percent) were the most common. Among dietary supplements associated with DILI, those that claim to promote weight loss and muscle building accounted for almost 60 percent of cases. At least 20 percent of DILI patients ingested more than one potentially liver-damaging agent.

There was no association between patient gender and severity of DILI, but patients with diabetes had more severe DILI.

The study was published in the journal Gastroenterology.

"DILI is a serious health problem that impacts patients, physicians, government regulators and the pharmaceutical industry. Further efforts are needed in defining its pathogenesis and developing means for the early detection, accurate diagnosis, prevention and treatment," Chalasani said in an American Gastroenterological Association news release.

The researchers noted that DILI remains a diagnosis of exclusion, which means that detailed testing needs to be performed to exclude other causes of liver disease. They emphasized that in patients with suspected DILI, acute hepatitis C virus (HCV) infection should be carefully ruled out through the use of HCV RNA testing.

More information

The American Liver Foundation has more about liver disease.



-- Robert Preidt



SOURCE: American Gastroenterology Association, news release, Dec. 1, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Long-term antibiotics reduce COPD exacerbations, raise questions
2. Antibiotics can cause pervasive, persistant changes to microbiota in human gut
3. Researchers find new chemical key that could unlock hundreds of new antibiotics
4. Scientists Hot on Trail of New Antibiotics
5. Antibiotics May Not Cause Diarrheal Bacteria
6. Wheezing after early-life antibiotics
7. Physicians ask EPA, Antibiotics to cure sick apples, or sick children?
8. Averting postsurgical infections in kids: Give antibiotics within hour before first incision
9. LegalView Reveals Details of the FDA Mandated Black Box Warning For Fluoroquinolone Antibiotics Such as Cipro and Levaquin
10. FDA Mandates Black Box Warning for Some Antibiotics
11. Federal Action Needed to Fill Antibiotic Pipeline, Says the Alliance for the Prudent Use of Antibiotics
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Antibiotics Largest Cause of Drug-Induced Liver Damage
(Date:6/23/2017)... ... , ... 21 Middle East and South Asia Leaders Selected as Eisenhower Fellows ... and civil society in 11 countries across the Middle East and South Asia to ... exchange of knowledge and ideas with the leading minds in their fields. , ...
(Date:6/23/2017)... ... 23, 2017 , ... PureLife Dental is pleased to announce that California Dental ... As part of the amalgam separator endorsement, all CDA members may purchase an ECO ... the retail value. This partnership between PureLife and CDA is especially timely as it ...
(Date:6/23/2017)... ... June 23, 2017 , ... American Farmer, will feature Chr. ... is slated to air fourth quarter 2017. American Farmer airs Tuesdays at 8:30aET on ... Danish pharmacist, founded Chr. Hansen in Denmark in 1874 after a groundbreaking discovery of ...
(Date:6/23/2017)... (PRWEB) , ... June 23, 2017 , ... ... management, financial planning, and related services to families and business owners in and ... charity drive to benefit senior citizens in the area. , Meals on Wheels ...
(Date:6/23/2017)... ... , ... All-Star Insurance, a family managed agency that offers insurance management assistance ... the launch of a new charity drive to benefit women in the area diagnosed ... that an estimated 252, 710 new cases of invasive or high risk breast cancer ...
Breaking Medicine News(10 mins):
(Date:6/2/2017)... LAWRENCE, Mass. , June 2, 2017  NxStage ... advancing renal care, today announced new findings demonstrating positive ... NxStage ® System One™. The data will be ... 2017, in Madrid, Spain . ... Knowledge to Improve Home Dialysis Network in ...
(Date:5/29/2017)... TEL AVIV, Israel, May 29, 2017  Cellect Biotechnology ... of innovative technology which enables the functional selection of ... financial results for the first quarter ended March 31 ... pleased with our accomplishments in the first quarter of ... the first quarter, we announced the treatment of the ...
(Date:5/22/2017)... , May 22, 2017  Lilac Corp, ... Gene-Eden-VIR/Novirin, announces the launch of a new ... the results of a clinical study that showed ... treatment with Gene-Eden-VIR/Novirin in individuals suffering from HPV ... note that there are no other treatments that ...
Breaking Medicine Technology: