Navigation Links
Antibiotics Largest Cause of Drug-Induced Liver Damage
Date:12/1/2008

Prescription meds, supplements can also trigger acute organ failure, study says

MONDAY, Dec. 1 (HealthDay News) -- Antibiotics are the single largest class of drugs that cause idiosyncratic drug-induced liver injury (DILI), researchers say.

The condition accounts for about 13 percent of cases of acute liver failure in the United States and is the most common cause of death from acute liver failure.

DILI is caused by a wide range of prescription and nonprescription medications, nutritional supplements and herbal products. In a new study, Indiana University School of Medicine researchers looked at patients with suspected DILI and found that 73 percent of cases were caused by a single prescription medication, 9 percent by dietary supplements, and 18 percent by multiple agents. Patients with acetaminophen-related liver damage weren't included in the study.

Lead author Dr. Naga P. Chalasani and colleagues found that more than 100 different agents were associated with DILI and that antibiotics (45.5 percent) and nervous system agents (15 percent) were the most common. Among dietary supplements associated with DILI, those that claim to promote weight loss and muscle building accounted for almost 60 percent of cases. At least 20 percent of DILI patients ingested more than one potentially liver-damaging agent.

There was no association between patient gender and severity of DILI, but patients with diabetes had more severe DILI.

The study was published in the journal Gastroenterology.

"DILI is a serious health problem that impacts patients, physicians, government regulators and the pharmaceutical industry. Further efforts are needed in defining its pathogenesis and developing means for the early detection, accurate diagnosis, prevention and treatment," Chalasani said in an American Gastroenterological Association news release.

The researchers noted that DILI remains a diagnosis of exclusion, which means that detailed testing needs to be performed to exclude other causes of liver disease. They emphasized that in patients with suspected DILI, acute hepatitis C virus (HCV) infection should be carefully ruled out through the use of HCV RNA testing.

More information

The American Liver Foundation has more about liver disease.



-- Robert Preidt



SOURCE: American Gastroenterology Association, news release, Dec. 1, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Long-term antibiotics reduce COPD exacerbations, raise questions
2. Antibiotics can cause pervasive, persistant changes to microbiota in human gut
3. Researchers find new chemical key that could unlock hundreds of new antibiotics
4. Scientists Hot on Trail of New Antibiotics
5. Antibiotics May Not Cause Diarrheal Bacteria
6. Wheezing after early-life antibiotics
7. Physicians ask EPA, Antibiotics to cure sick apples, or sick children?
8. Averting postsurgical infections in kids: Give antibiotics within hour before first incision
9. LegalView Reveals Details of the FDA Mandated Black Box Warning For Fluoroquinolone Antibiotics Such as Cipro and Levaquin
10. FDA Mandates Black Box Warning for Some Antibiotics
11. Federal Action Needed to Fill Antibiotic Pipeline, Says the Alliance for the Prudent Use of Antibiotics
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Antibiotics Largest Cause of Drug-Induced Liver Damage
(Date:12/6/2016)... (PRWEB) , ... December 06, 2016 , ... ... advisory organization, is proud to announce it has added CXC Solutions (CXC) as ... management solutions. These solutions are tailored to help benefits advisors reduce operating ...
(Date:12/6/2016)... ... December 06, 2016 , ... ... portal for all the knowledge resources, including white papers, guides, handbooks, case studies, ... , To access more than 9,000 documents, webinars and videos available online, ...
(Date:12/6/2016)... ... December 06, 2016 , ... “Tatiana Sibirskaya: A Life ... story of sacrifice and enlightenment. , “Tatiana Sibirskaya: A Life Devoted ... looking for creative outlets, Carolyn gravitated toward writing through the inspiration of her ...
(Date:12/6/2016)... ... December 06, 2016 , ... U.S. Security Associates (USA) ... 125 for their industry leading training methods that engage their associates and link ... the global elite in employer-sponsored training and development programs. , “The 2017 Training ...
(Date:12/5/2016)... ... December 06, 2016 , ... For many years, Andrew G. Zubinas ... thin. The beauty of the Lithuanian language and its poetry inspired him ... book, Zubinas lyrically explores all aspects of a living, breathing forest where nothing ever ...
Breaking Medicine News(10 mins):
(Date:12/5/2016)... 2016  CVS Health, the nation,s largest pharmacy innovation ... score of 100 percent on the Corporate Equality Index ... an annual national benchmarking survey and report on corporate ... the Human Rights Campaign Foundation. "Our ... colleagues, customers and suppliers bring to CVS Health," said ...
(Date:12/5/2016)... 2016  New research by the CVS Health ... the U.S. Department of Health and Human Services, ... Response (ASPR), published online today in JAMA ... encourage patients with chronic conditions to refill medications ... also affirms that public-private partnerships can facilitate timely ...
(Date:12/5/2016)... 5, 2016 For the third consecutive year, ... Human Rights Campaign Foundation,s (HRC) annual ... national benchmarking tool used to rate companies on policies ... employee equality. For the last 15 years, ... gauge their equality efforts, culture and business practices. The ...
Breaking Medicine Technology: