Navigation Links
Antibiotics Largest Cause of Drug-Induced Liver Damage
Date:12/1/2008

Prescription meds, supplements can also trigger acute organ failure, study says

MONDAY, Dec. 1 (HealthDay News) -- Antibiotics are the single largest class of drugs that cause idiosyncratic drug-induced liver injury (DILI), researchers say.

The condition accounts for about 13 percent of cases of acute liver failure in the United States and is the most common cause of death from acute liver failure.

DILI is caused by a wide range of prescription and nonprescription medications, nutritional supplements and herbal products. In a new study, Indiana University School of Medicine researchers looked at patients with suspected DILI and found that 73 percent of cases were caused by a single prescription medication, 9 percent by dietary supplements, and 18 percent by multiple agents. Patients with acetaminophen-related liver damage weren't included in the study.

Lead author Dr. Naga P. Chalasani and colleagues found that more than 100 different agents were associated with DILI and that antibiotics (45.5 percent) and nervous system agents (15 percent) were the most common. Among dietary supplements associated with DILI, those that claim to promote weight loss and muscle building accounted for almost 60 percent of cases. At least 20 percent of DILI patients ingested more than one potentially liver-damaging agent.

There was no association between patient gender and severity of DILI, but patients with diabetes had more severe DILI.

The study was published in the journal Gastroenterology.

"DILI is a serious health problem that impacts patients, physicians, government regulators and the pharmaceutical industry. Further efforts are needed in defining its pathogenesis and developing means for the early detection, accurate diagnosis, prevention and treatment," Chalasani said in an American Gastroenterological Association news release.

The researchers noted that DILI remains a diagnosis of exclusion, which means that detailed testing needs to be performed to exclude other causes of liver disease. They emphasized that in patients with suspected DILI, acute hepatitis C virus (HCV) infection should be carefully ruled out through the use of HCV RNA testing.

More information

The American Liver Foundation has more about liver disease.



-- Robert Preidt



SOURCE: American Gastroenterology Association, news release, Dec. 1, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Long-term antibiotics reduce COPD exacerbations, raise questions
2. Antibiotics can cause pervasive, persistant changes to microbiota in human gut
3. Researchers find new chemical key that could unlock hundreds of new antibiotics
4. Scientists Hot on Trail of New Antibiotics
5. Antibiotics May Not Cause Diarrheal Bacteria
6. Wheezing after early-life antibiotics
7. Physicians ask EPA, Antibiotics to cure sick apples, or sick children?
8. Averting postsurgical infections in kids: Give antibiotics within hour before first incision
9. LegalView Reveals Details of the FDA Mandated Black Box Warning For Fluoroquinolone Antibiotics Such as Cipro and Levaquin
10. FDA Mandates Black Box Warning for Some Antibiotics
11. Federal Action Needed to Fill Antibiotic Pipeline, Says the Alliance for the Prudent Use of Antibiotics
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Antibiotics Largest Cause of Drug-Induced Liver Damage
(Date:5/27/2016)... New York, NY (PRWEB) , ... May 27, 2016 , ... ... the factors of a stroke, which we as a society can control and change. ... a stroke occurs nearly every 40 seconds within the United States. Plus, with an ...
(Date:5/27/2016)... ... ... Beleza Medspa has initiated a new program to assist active duty ... that Coolsculpting is being used for for more than just cosmetic purposes. ... prescribed body-fat standard, measured by the circumference-based tape method. The tape-test is used ...
(Date:5/27/2016)... ... 27, 2016 , ... Each year Standard Process Inc. ... is this year’s Life University winner of a $2,500 scholarship from ... Leadership Awards ceremony. , Outerbridge is approaching her last quarter at Life University ...
(Date:5/26/2016)... ... 2016 , ... There are many ways to cook a hot dog, but ... Americans prefer their dogs straight off the grill. Of the 90 percent of Americans ... to cook a hot dog, far outpacing other cooking methods such as steaming (12 ...
(Date:5/26/2016)... , ... May 26, 2016 , ... ... clinical outcomes, hosted members and suppliers for its inaugural Member Conference at the ... their mission of elevating the operational health of America’s healthcare providers. , The ...
Breaking Medicine News(10 mins):
(Date:5/24/2016)... AMSTERDAM , May 24, 2016 ... aplicación médica para ayudar a los médicos a compartir ... los pacientes a escala mundial. Profesionales médicos de Europa, ... ya se han apuntado a la aplicación, que combina ... en un entorno totalmente seguro. Educación   ...
(Date:5/24/2016)... CHRISTCHURCH, New Zealand , May 24, 2016 ... scanning and informatics solutions for the healthcare sector, has been ... the New Zealand Hi-Tech Awards 2016. Dr ... a fantastic acknowledgement for our team.  It,s really good to ... the burden healthcare internationally. Our products are used in 35 ...
(Date:5/24/2016)... KONG , May 24, 2016 ... , the world , s first ... AV fistula intervention   OrbusNeich, a global ... has expanded its portfolio to include products to treat ... are the company,s first entry devices for lower limb ...
Breaking Medicine Technology: