Navigation Links
Antibiotic therapy reduces mortality by 68 percent in hemodialysis patients
Date:7/2/2014

DETROIT An antibiotic therapy known to reduce catheter-related bloodstream infections in hemodialysis patients has been shown for the first time to reduce mortality, according to a Henry Ford Health System study.

Researchers found that a low-dose "lock" solution of gentamicin/citrate reduced mortality by 68 percent compared to a solution of heparin, a blood-clotting therapy long considered the standard of care. Additionally, the gentamicin/citrate solution was associated with a 73 percent reduction in bloodstream infections compared to the heparin treatment.

Bloodstream infections are a leading cause of hospitalization and death in hemodialysis patients.

The findings are published online in the Clinical Journal of the American Society of Nephrology at http://bit.ly/1nZlCpd, and will appear in the journal's July print edition. An editorial accompanies the study.

Jerry Yee, M.D., division head of Nephrology and Hypertension at Henry Ford and the study's senior author, says the findings suggest the antibiotic therapy is a potential game-changer for hemodialysis treatment.

"Advances in treatment have been elusive over the years. Perhaps our study can be a starting point to change the paradigm as a standard of care," Dr. Yee says. "The gentamicin/citrate solution was shown to be both safe and effective."

For their prospective, observational study involving 749 patients from September 2008 to June 2011, researchers compared the two therapeutic solutions. There were 427 patients in the heparin study arm and 322 in the gentamicin/citrate arm. The solutions were administered using an antibiotic locking-technique that prevents catheter clotting and reduces infection.

Multiple studies have shown the benefit of using an antibiotic locking strategy for reducing bloodstream infections. However, the Centers for Disease Control and Prevention and Infectious Diseases Society of America do not recommend the use of the solutions amid concern of a potential antimicrobial resistance with gentamicin/citrate. However, Henry Ford researchers found that gentamicin resistance rates deceased two-fold.


'/>"/>

Contact: David Olejarz
David.Olejarz@hfhs.org
313-874-4094
Henry Ford Health System
Source:Eurekalert  

Related medicine news :

1. Antibiotics Linked to Retinal Detachment Risk
2. Researchers find evidence of banned antibiotics in poultry products
3. Study Finds Antibiotics Best for Appendicitis
4. FDA Seeks to Limit Antibiotics in Animal Feed
5. Probiotic Products May Prevent Antibiotic-Linked Diarrhea
6. Study Links Antibiotic to Slight Rise in Heart Patients Death Risk
7. Study shows antibiotic improves respiratory function in lung transplant patients
8. Antibiotic-Resistant Gonorrhea Spreading: WHO
9. A non-antibiotic approach for treating urinary tract infections
10. Trivedi Beef, LLC Announces Breakthrough Beef Industry Data without the use of Antibiotic Drugs, Hormones or Steroids
11. Study examines role of seasonal prescribing changes in antibiotic resistance
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Antibiotic therapy reduces mortality by 68 percent in hemodialysis patients
(Date:2/12/2016)... Pa. (PRWEB) , ... February 12, 2016 , ... Every ... heaters. , This winter the West Penn Burn Center, part of the ... Company #1, to bring you the “Space Heaters Need Space” campaign. ...
(Date:2/12/2016)... ... February 12, 2016 , ... The Jones Agency, a ... across eastern Texas, is launching a cooperative charity drive with the Tarrant Area Food ... more than 50,000 individuals and families in need, the Tarrant County Food Bank offers ...
(Date:2/12/2016)... , ... February 12, 2016 , ... ... the Pittsburgh metro area, celebrates the beginning of the latest charity campaign in ... social skills through art. Donations to this worthy cause are currently being accepted ...
(Date:2/12/2016)... , ... February 12, 2016 , ... For Coast Dental ... Suzan Sweeney, RDH, and dental assistant Terrell Moore shortly before 7 a.m. to volunteer ... of dental professionals, donating their time and skills to help hundreds of uninsured and ...
(Date:2/12/2016)... ... February 12, 2016 , ... Nearly every health website and ... These articles generally list between five and 15 foods that should be consumed ... one of these lists and believes that nutritious eye healthy foods are extremely ...
Breaking Medicine News(10 mins):
(Date:2/12/2016)... , Maharashtra, February 12, 2016 ... research report titled Chronic Inflammation Global Clinical Trials ... snapshot of the global clinical trials landscape along ... trials by Region, Country (G7 & E7), Trial ... status and reviews top companies involved and enlists ...
(Date:2/11/2016)... Feb. 11, 2016 Stem cells are primitive ... by self-renewal and the capacity to differentiate into mature ... discovery, as the first mouse embryonic stem cells were ... until 1995 that the first culturing of embryonic stem ... were not produced until 2006 As a result of ...
(Date:2/11/2016)... 11, 2016  Kindred Biosciences, Inc. (NASDAQ: KIN ... the lives of pets, today announced the submission to ... Animal Drug Application (NADA) for Zimeta™ (dipyrone injection, KIND-012).  ... of Zimeta for the control of pyrexia (fever) in ... --> --> The Chemistry, Manufacturing, ...
Breaking Medicine Technology: