Navigation Links
Antibiotic-resistant bacteria among children in the United States on the rise
Date:3/20/2014

(Chicago)--Infections caused by a specific type of antibiotic-resistant bacteria are on the rise in U.S. children, according to new study published in the Journal of the Pediatric Infectious Diseases Society. While still rare, the bacteria are increasingly found in children of all ages, especially those 1-5 years old, raising concerns about dwindling treatment options.

"Some infections in children that have typically been treated with oral antibiotics in the past may now require hospitalization, treatment with intravenous drugs, or both, as there may not be an oral treatment option available," said Dr. Latania K. Logan, lead author of the study and an assistant professor of pediatrics and pediatric infectious disease specialist at Rush University Medical Center.

The team of researchers led by Logan analyzed resistance patterns in approximately 370,000 bacterial cultures from pediatric patients collected nationwide between 1999 and 2011.

They found that the prevalence is increasing in a resistant type of bacteria, which produces a key enzyme, extended-spectrum beta-lactamase (ESBL), that thwarts many strong antibiotics, making them ineffective.

Another indicator of ESBL prevalence, susceptibility to third-generation cephalosporinsan important class of antibiotics used to treat many infectionswas also measured.

The prevalence of ESBL-producing bacteria increased from 0.28 percent to 0.92 percent from 1999 to 2011; resistance to third-generation cephalosporins increased from 1.4 percent to 3.0 percent. ESBLs were found in children across the country of all ages, but slightly more than half of the bacteria with this resistance were from those 1-5 years old. Nearly three-quarters (74.4 percent) of these bacteria were resistant to multiple classes of antibiotics.

While the overall rate of these infections in children is still low, ESBL-producing bacteria can spread rapidly and have been linked to longer hospital stays, higher health care costs, and increased mortality, the study authors noted. In a 2013 report, the Centers for Disease Control and Prevention called ESBLs a "serious concern" and a significant threat to public health.

"These antibiotic-resistant bacteria have traditionally been found in health care settings but are increasingly being found in the community, in people who have not had a significant history of health care exposure," Logan said. "In our study, though previous medical histories of the subjects were unknown, 51.3 percent of the children with these infections presented in the outpatient or ambulatory setting."

"Physicians should obtain cultures for suspected bacterial infections to help determine which antibiotics are best," said Logan.

Additional drug development, keeping younger patients in mind, is also needed. "The overwhelming majority of current research for new pharmaceuticals against antibiotic-resistant organisms are in adults," said Logan.

"More research is needed to define risk factors for these infections in children, their prevalence in different settings, and their molecular epidemiology," Logan said. A companion study by several of the same researchers is now available online in the Journal of the Pediatric Infectious Diseases Society, which suggests that children with neurologic conditions are at higher risk for infections caused by ESBL-producing bacteria.


'/>"/>

Contact: Nancy DiFiore
nancy_difiore@rush.edu
312-942-5159
Rush University Medical Center
Source:Eurekalert

Related medicine news :

1. Antibiotic-Resistant Gonorrhea Spreading: WHO
2. Synthetic corkscrew peptide kills antibiotic-resistant Gram-negative bacteria
3. Strains of antibiotic-resistant Staph bacteria show seasonal preference; Children at higher risk in summer
4. Antibiotic-resistant strain of E. coli increasing among older adults and residents of nursing homes
5. Pharmacy Robots Linked to Bacterial Contamination of Drugs
6. Children with juvenile arthritis have higher rates of bacterial infection
7. University of Minnesota startup to treat challenging bacterial infection
8. Fish Pedicure a Recipe for Bacterial Infection, Researchers Warn
9. Zooming in on bacterial weapons in 3-D
10. Genomes show how Staph bacteria gain resistance to last-line drug
11. Cedars-Sinai physician definitively links irritable bowel syndrome and bacteria in gut
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/14/2017)... (PRWEB) , ... January 13, 2017 , ... ... Body and Soul, incorporating a magnesium-rich Mediterranean diet may lower the risk of ... and Lounge notes that the many health and wellness benefits linked to a ...
(Date:1/13/2017)... ... ... The 18th European Congress: Perspectives in Lung Cancer will be held in Madrid ... expertly designed to meet the educational needs of European oncology clinicians and researchers who ... Giorgio V. Scagliotti, Professor of Oncology at the University of Torino, and organized by ...
(Date:1/13/2017)... ... January 13, 2017 , ... An inventor from Pahrump, Nev., used an unsavory medical experience to ... wear a Foley catheter and urine bag for a half year due to lazy bladder," ... that there should be a better way to do this." , He then designed and ...
(Date:1/13/2017)... ... January 13, 2017 , ... Friday, January 13 at 5 ... game room, increasing the size of the location to 90,000 square feet. , Included ... golf course that takes customers on an educational tour of the historic route, with ...
(Date:1/13/2017)... ... January 13, 2017 , ... As the nation watches this month’s ... of colleges and schools of education across the country is urging a fundamental reconsideration ... of Principles released today, 175 deans sounded the alarm: “Our children suffer when we ...
Breaking Medicine News(10 mins):
(Date:1/13/2017)... Concord Medical Services Holdings Limited ("Concord Medical" ... leading specialty hospital management solution provider and operator of ... in China , announced that it ... Trust Co., Ltd. ("ZRT"). The Company signed ... Taihe Healthcare Fund in October 2016. The total amount of ...
(Date:1/13/2017)... 2017  Biologics Prescribers Collaborative (BPC) applauds ... for issuing final guidance calling for distinguishable ... is an important win for patients and ... pharmacovigilance, patient safety and transparency. ... FDA, we remain concerned with "random" suffixes called for ...
(Date:1/12/2017)... -- Cervical cancer test market in Asian region is growing ... declining women population, Japan has highest ... Indonesia is dominating in cervical cancer testing population ... rising sum of structured cervical cancer programs introduced by governments ... are some of the major growth drivers for the growth ...
Breaking Medicine Technology: