Navigation Links
Antibiotic Combo Fights Resistant TB
Date:2/26/2009

2 FDA-approved drugs inhibit both normal and virulent strains, study finds

THURSDAY, Feb. 26 (HealthDay News) -- Combination treatment with two FDA-approved drugs shows promise in treating extensively drug-resistant tuberculosis (XDR-TB), a U.S. study shows.

In laboratory tests, researchers at the Albert Einstein College of Medicine and the National Institute of Allergy and Infectious Diseases found that a combination of the drugs clavulanate and meropenem inhibited the growth of 13 XDR-TB strains. The combination treatment was also effective against normal TB. Both drugs are approved in the United States for treating other bacterial infections in adults and children.

The study was published in the Feb. 27 issue of Science.

Current therapy for normal TB requires four antibiotics that must be taken for at least six months. XDR-TB is resistant to at least four of the drugs used to treat TB. The cure rate for patients with XDR-TB is 12 percent to 60 percent.

"If proven in human subjects, the ability to simplify treatment to just two drugs that work against drug-susceptible [TB], multi-drug-resistant [TB] and XDR-TB could help patients better adhere to therapy," study senior author John S. Blanchard, a professor of biochemistry at Einstein, said in a college news release.

"This discovery could be one of the most promising developments in TB research since the discovery of isoniazid -- it is very exciting," William Jacobs, a professor of microbiology and immunology at Einstein and associate director of the Einstein-Montefiore Center for AIDS Research, said in the news release. Isoniazid, the first effective anti-tuberculosis medication, was discovered in the 1950s.

Plans are under way for clinical studies in Korea and in South Africa to determine whether the combination treatment is effective in patients with XDR-TB.

This highly dangerous form of TB is rare in the United States, with only 83 documented cases in the country between 1993 and 2007. However, XDR-TB is emerging as a serious problem in some developing nations.

More information

The U.S. Centers for Disease Control and Prevention has more about XDR-TB.



-- Robert Preidt



SOURCE: Albert Einstein College of Medicine, news release, Feb. 26, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. New antibiotic drug combo to speed up treatment of tuberculosis
2. Newer Antibiotic Speeds TB Healing
3. Antibiotics Not Always Best Bet for Battling Childhood Ear Infections
4. Antibiotic Shows Promise as Stroke Treatment
5. Ear infection superbug discovered to be resistant to all pediatric antibiotics
6. Antibiotics May Not Help Mens Chronic Pelvic Pain: Harvard Doctors Discuss Alternatives
7. Study Shows Antibiotic Harms ALS Patients
8. Dragon Sells EPO Business; Focus on Antibiotic Core Business
9. Drug Combo With Antibiotic May Slow MS Progression
10. Antibiotic treatment targets difficult asthma
11. New Report Underscores Need for Congressional Action to Limit Antibiotic Use in Animal Agriculture
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Antibiotic Combo Fights Resistant TB
(Date:4/29/2016)... ... April 29, 2016 , ... Jvion, the ... of funding led by Eastside Partners, with participation from existing investor Martin Ventures. ... base and accelerate its technology and product roadmap. , “Jvion is ...
(Date:4/29/2016)... ... 2016 , ... CURE Media Group , the nation’s ... today announced that Lynne Malestic, RN, of Eisenhower Lucy Curci Cancer Center in ... Oncology Nursing , which honors nurses who have dedicated their careers to helping ...
(Date:4/29/2016)... ... April 29, 2016 , ... Natren, Inc. ... line of probiotics, Petbiotics ™, as they fondly call them. As animal ... groups networking for their non-profit organizations. Animal rescues across the nation face huge ...
(Date:4/29/2016)... (PRWEB) , ... April 29, 2016 , ... ... raising awareness for Duchenne muscular dystrophy, and funding for Duchenne research, participated in ... efficacy of the Sarepta Therapeutic’s novel Duchenne drug eteplirsen. The meeting at the ...
(Date:4/29/2016)... ... April 29, 2016 , ... ... 2014. Each year, reproductive endocrinologists are required to report in vitro fertilization ... of professionals dedicated to the practice of assisted reproductive technologies in the United ...
Breaking Medicine News(10 mins):
(Date:4/28/2016)... , April 28, 2016 ... H1 2016" is a report that provides an ... strengthen R&D pipelines by identifying new targets and ... Company Profiles discussed in this H1 2016 ... Riunite Srl, AbbVie Inc., Abiogen Pharma S.p.A., Ablynx ...
(Date:4/27/2016)... le 27 Avril 2016 ... progressé de +5% sur le trimestre, soutenu par ... consommables  Croissance de +16% des ventes ... Mauna Kea Technologies (Euronext : MKEA, FR0010609263 ; OTCQX : ... laser, annonce aujourd,hui son chiffre d,affaires pour le ...
(Date:4/27/2016)... 27, 2016 Transparency Market Research ... Market - Global Industry Analysis, Size, Share, Growth, Trends, ... the global skincare devices market was valued at US$ ... at a CAGR of 10.1% from 2015 to 2023 ... Browse the full Skincare Devices Market (Treatment Device - LED ...
Breaking Medicine Technology: