Navigation Links
Antibiotic Combo Fights Resistant TB
Date:2/26/2009

2 FDA-approved drugs inhibit both normal and virulent strains, study finds

THURSDAY, Feb. 26 (HealthDay News) -- Combination treatment with two FDA-approved drugs shows promise in treating extensively drug-resistant tuberculosis (XDR-TB), a U.S. study shows.

In laboratory tests, researchers at the Albert Einstein College of Medicine and the National Institute of Allergy and Infectious Diseases found that a combination of the drugs clavulanate and meropenem inhibited the growth of 13 XDR-TB strains. The combination treatment was also effective against normal TB. Both drugs are approved in the United States for treating other bacterial infections in adults and children.

The study was published in the Feb. 27 issue of Science.

Current therapy for normal TB requires four antibiotics that must be taken for at least six months. XDR-TB is resistant to at least four of the drugs used to treat TB. The cure rate for patients with XDR-TB is 12 percent to 60 percent.

"If proven in human subjects, the ability to simplify treatment to just two drugs that work against drug-susceptible [TB], multi-drug-resistant [TB] and XDR-TB could help patients better adhere to therapy," study senior author John S. Blanchard, a professor of biochemistry at Einstein, said in a college news release.

"This discovery could be one of the most promising developments in TB research since the discovery of isoniazid -- it is very exciting," William Jacobs, a professor of microbiology and immunology at Einstein and associate director of the Einstein-Montefiore Center for AIDS Research, said in the news release. Isoniazid, the first effective anti-tuberculosis medication, was discovered in the 1950s.

Plans are under way for clinical studies in Korea and in South Africa to determine whether the combination treatment is effective in patients with XDR-TB.

This highly dangerous form of TB is rare in the United States, with only 83 documented cases in the country between 1993 and 2007. However, XDR-TB is emerging as a serious problem in some developing nations.

More information

The U.S. Centers for Disease Control and Prevention has more about XDR-TB.



-- Robert Preidt



SOURCE: Albert Einstein College of Medicine, news release, Feb. 26, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. New antibiotic drug combo to speed up treatment of tuberculosis
2. Newer Antibiotic Speeds TB Healing
3. Antibiotics Not Always Best Bet for Battling Childhood Ear Infections
4. Antibiotic Shows Promise as Stroke Treatment
5. Ear infection superbug discovered to be resistant to all pediatric antibiotics
6. Antibiotics May Not Help Mens Chronic Pelvic Pain: Harvard Doctors Discuss Alternatives
7. Study Shows Antibiotic Harms ALS Patients
8. Dragon Sells EPO Business; Focus on Antibiotic Core Business
9. Drug Combo With Antibiotic May Slow MS Progression
10. Antibiotic treatment targets difficult asthma
11. New Report Underscores Need for Congressional Action to Limit Antibiotic Use in Animal Agriculture
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Antibiotic Combo Fights Resistant TB
(Date:8/24/2017)... ... August 24, 2017 , ... Lori ... the development and advances in Desensitization therapy to improve the outcomes of organ ... about his remarkable journey of his 25 years of research in developing therapies ...
(Date:8/24/2017)... ... August 24, 2017 , ... Prime candidates for home ... have a condition that needs further monitoring such as surgery, stroke, heart attack ... stable, such as diabetes, high blood pressure, heart/lung disease, arthritis and stroke. ...
(Date:8/23/2017)... ... 2017 , ... The Arc Mercer, Capitol County’s premier provider of programs and ... community organization for people with special needs. The group, the Special Needs Alliance for ... of New Jersey – but the first in the entire country! , SNAP was ...
(Date:8/23/2017)... ... 2017 , ... Drs. Steven White and Brad Haines are pleased to announce ... of this offer, valued at more than $300 per year, new patients can enjoy ... patients receive a complimentary professional whitening procedure. , Stained or yellowed tooth enamel ...
(Date:8/23/2017)... ... ... Awards have announced the winners of the Best of the IBA Awards in The 2017 ... in the 2017 IBAs were not able to apply for the Best of the IBA ... awards won in the IBAs with a Gold Stevie win counting for three points, a ...
Breaking Medicine News(10 mins):
(Date:8/15/2017)... 2017   Mostyn Law and Gulf Coast Regional Blood ... . The Mostyn Law family has had 3 ... is why Mostyn Law is partnering with Gulf Coast ... its appreciation. Blood supplies are running low. Gulf Coast ... hospital needs in August. That is why the blood center reached ...
(Date:8/15/2017)... , Aug. 15, 2017  AOTI Inc. announced today that ... Therapy Inc., has recently opened a New York City Office in ... usage of its unique Topical Wound Oxygen (TWO 2 ) homecare ... the Accreditation Commission for Health Care (ACHC) under the company,s DMEPOS ... ...
(Date:8/8/2017)... -- BioLineRx Ltd. (NASDAQ/TASE: BLRX), a clinical-stage biopharmaceutical company focused ... for the second quarter ended June 30, 2017. ... and to date: ... Company,s lead project, BL-8040: Announced plans ... novel stem cell mobilization treatment for autologous bone-marrow transplantation ...
Breaking Medicine Technology: