Navigation Links
Anti-tumor necrosis factor treatment does not increase cancer Risk in RA patients
Date:10/28/2009

A recent study by Swedish researchers found that rheumatoid arthritis (RA) patients did not experience an elevated cancer risk in the first 6 years after starting anti-tumor necrosis factor (TNF) therapy. The research team, led by Johan Askling, M.D., Ph.D., from Karolinska University Hospital in Stockholm, Sweden assessed the short-term and medium-term cancer risk for RA patients using anti-TNF therapies: infliximab, adalimumab, and etanercept. Details of the study appear in the November issue of Arthritis & Rheumatism, a journal of the American College of Rheumatology published by Wiley-Blackwell.

TNF is a cytokine (substance secreted by immune system cells) that regulates the body's immune system and is involved in inflammation. TNF inhibitors (or TNF blockers) are a class of therapies used to reduce inflammation in chronic inflammation such as RA. The common immunosuppressant drugs and those included in the study are Remicade, HumiraTM, and Enbrel. As these therapies are used to treat chronic inflammatory illnesses, the long-term inhibition of TNF raises concerns for increased risk of infections and cancer.

This study, one of the largest and longest population-based assessments of cancer risks associated with immunosuppressive therapy, included data from several Swedish databases including the Biologics Register, the Cancer Register, and the Early RA Register. Researchers identified and analyzed data from 6,366 patients who started anti-TNF therapy between January 1999 and July 2006. Data from patients using TNF inhibitors was compared with other groups of RA patients61,160 not taking medication, 4015 using methotrexate (the gold standard in RA treatment) and 4,015 taking combinations of disease-modifying anti-rheumatic drugs (other than TNF inhibitors).

Results show there were 240 first primary cancers diagnosed during the 25,693 person-years of follow-up in the patients using anti-TNF therapy who had no histor
'/>"/>

Contact: Dawn Peters
medicalnews@wiley.com
781-388-8408
Wiley-Blackwell
Source:Eurekalert

Page: 1 2

Related medicine news :

1. CD200 stifles anti-tumor immunity
2. A new light on the anti-tumor mechanisms of Scutellaria barbata
3. Mersanas Second Development Candidate, XMT-1107, Shows Superior Pharmacokinetics and Anti-Tumor Activity in Studies Presented at American Association of Cancer Research Meeting
4. Short-term stress enhances anti-tumor activity in mice, Stanford study shows
5. Massive necrosis after trans-catheter treatment is more common in the presence of tumor capsule
6. Popular osteoporosis drugs triple risk of bone necrosis
7. Link between treating osteoporosis with bisphosphonates and incidence of bone necrosis examined
8. Effect of tumor necrosis factor a inhibitors on heart failure risk in RA Patients
9. USC dentist links Fosomax-type drugs to jaw necrosis
10. Orthopedic Surgeon Dr. Marc W. Hungerford, a Leading Expert in Field of Avascular Necrosis, Now at Baltimore's Mercy Medical Center
11. Amgen and Wyeth Statement on FDA Announcement About Tumor Necrosis Factor (TNF) Blockers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2015)... 24, 2015 For people who are ... Enterokinase Industry, 2009-2019 Market Research Report would be an ... exhaustive study on the present market scenario of this ... the growing Chinese market of this industry. The report ... status of the manufacturers in this industry. The report ...
(Date:5/24/2015)... ProPin is a set of self-animating 3D pin markers ... to pin point locations on a map, to indicate prices or ... users to choose from 30 simplistic presets with geometric design elements ... editors can easily manipulate ProPin presets as a whole. Pixel ... , Using ProPin is easy, simply drag a preset into the ...
(Date:5/23/2015)... FL (PRWEB) May 23, 2015 On Saturday, ... build a new playground for Branches Florida City exactly five ... former play space in 2010. , A large fire tore ... playground on May 23, 2010 in the middle of the ... The fire was later declared arson even though it is ...
(Date:5/23/2015)... 2015 On May 16, the team at ... was a 5k mud obstacle run that raised funds for ... people worldwide, and the reason we participated was to support ... owner of Farrell’s eXtreme Bodyshaping. “One-hundred percent of the funds ... The event was not only attended by eXtreme Bodyshaping staff, ...
(Date:5/23/2015)... Baltimore, MD (PRWEB) May 23, 2015 Injury ... moratorium that has been passed by the Maryland legislature but ... , “The Maryland General Assembly passed HB 449 ... the Governor has not signed it into law. This bill ... 2017. Evidence is growing that demonstrates the danger of fracking ...
Breaking Medicine News(10 mins):Health News:Global and Chinese Enterokinase Industry 2009-2019 Market Research Report Now Available at RnRMarketResearch.com 2Health News:Global and Chinese Enterokinase Industry 2009-2019 Market Research Report Now Available at RnRMarketResearch.com 3Health News:Global and Chinese Enterokinase Industry 2009-2019 Market Research Report Now Available at RnRMarketResearch.com 4Health News:Developers at Pixel Film Studios Release ProPin for Final Cut Pro X. 2Health News:Five Years After Fire, Branches Rebuilds Playground 2Health News:Farrell’s eXtreme Bodyshaping Team Runs through the Muck for MS 2Health News:Baltimore Attorney Urges Governor Hogan to Sign the Fracking Moratorium Bill 2Health News:Baltimore Attorney Urges Governor Hogan to Sign the Fracking Moratorium Bill 3
... food costs, many families are,economizing on groceries but one thing ... cents per 8-ounce glass, on a gallon basis, milk offers,more ... the,supermarket -- proving key vitamins and minerals like calcium and ... moms don,t cut milk from,their grocery lists, the National got ...
... costs, many,families are economizing on groceries but one thing ... 25 cents per 8-ounce glass, on a gallon basis, ... beverage option in the,supermarket -- proving key vitamins and ... the entire family. To ensure moms don,t cut milk ...
... First DataBank, a leading,provider of integrated drug ... announced the company,s drug data has been,integrated into ... secure, Web-based platform that,facilitates on-demand, real-time Online and ... , Through ...
... Level of Usage Restrictions, According to a New Report ... , MALVERN, Penn. and WALTHAM, Mass.,Dec. 15 ... that the most important factors that influence antibiotic selection ... agent,s availability in intravenous (IV) formulation, activity against Pseudomonas ...
... Developed last year in response to,corporate America,s need for comprehensive EDI ... with a bigger, better and brand new,schedule of training for 2009. ... Schedule , Pre-registration for the ... decisively shown the need for as many sessions as possible;,consequently, EDI ...
... Life magazine, the upscale,men,s magazine from health and fitness publisher ... the best computer-based cognitive,training program. Best Life surveyed the ... and picked The Brain Fitness,Program as number one -- the ... 5 points. , The ...
Cached Medicine News:Health News:Milk is One Beverage Houston Can't Afford to Keep Off the Grocery List 2Health News:Milk is One Beverage Houston Can't Afford to Keep Off the Grocery List 3Health News:Milk is One Beverage Birmingham Can't Afford to Keep Off the Grocery List 2Health News:Milk is One Beverage Birmingham Can't Afford to Keep Off the Grocery List 3Health News:American Well Selects First DataBank's Drug Data for Use in Online Physician-Patient Care Consultations 2Health News:American Well Selects First DataBank's Drug Data for Use in Online Physician-Patient Care Consultations 3Health News:Most Important Factors Driving Usage of Antibiotics in the ICU Setting are Availability in Intravenous Formulation, Activity Against Key Gram Negative Pathogens, Drug Interactions and Bactericidal Activity 2Health News:Most Important Factors Driving Usage of Antibiotics in the ICU Setting are Availability in Intravenous Formulation, Activity Against Key Gram Negative Pathogens, Drug Interactions and Bactericidal Activity 3Health News:Fresh from Its 2008 Success, EDI Training Academy Expands into 2009 with 20 New Seminars and an EDI Health Care Best Practices Course 2Health News:Posit Science is Best in Brain Fitness Says Best Life 2
(Date:5/22/2015)... Richmond Pharmacology is a ... a worldwide reputation for excellence in clinical trials. ... peer reviewed medical journals. Its officers are engaged ... discussions about rules for transparency and publication of ... , Clinical research is conducted worldwide, ...
(Date:5/21/2015)... 2015  When Ryan Rendino first felt ... his neck, he figured it was a ... off from weight lifting. But ... A series of doctor appointments ... Michel Kliot, MD , a ...
(Date:5/21/2015)... Inc. (NYSE: CRY ), a leading medical device ... surgery, announced today that its Board of Directors has ... 2015 of $0.03 per share of common stock outstanding.  ... be paid on June 19, 2015 to all common ... ex-dividend date for the quarterly dividend is June 10, ...
Breaking Medicine Technology:Northwestern Medicine Surgeons Develop New Approach to Removing Nerve Tumors 2Northwestern Medicine Surgeons Develop New Approach to Removing Nerve Tumors 3Northwestern Medicine Surgeons Develop New Approach to Removing Nerve Tumors 4CryoLife Announces Quarterly Cash Dividend for the Second Quarter 2015 2
... Arena Pharmaceuticals, Inc. (Nasdaq: ARNA ) and ... (FDA) issued a Complete Response Letter (CRL) regarding Arena,s New ... management, including weight loss and maintenance of weight loss, in ... 30) or patients who are overweight (BMI >/= 27) and ...
... health care and hospice company (Nasdaq: AMED ), commends ... in this week,s issue of the New England Journal of Medicine. ... Titled, "Why Health Care is Going Home," Dr. ... as an increasingly crucial component of America,s health care system. As ...
Cached Medicine Technology:FDA Issues Complete Response Letter for Lorcaserin New Drug Application 2FDA Issues Complete Response Letter for Lorcaserin New Drug Application 3FDA Issues Complete Response Letter for Lorcaserin New Drug Application 4FDA Issues Complete Response Letter for Lorcaserin New Drug Application 5FDA Issues Complete Response Letter for Lorcaserin New Drug Application 6Media Statement From Amedisys on Dr. Steven H. Landers' NEJM Commentary on the Future of Home Care 2
Aspirating adjustable lid speculum is ideal for cataract and laser refractive procedures....
Open 11 mm blades. Dull finish. Most popular size or model....
Adjustable lid speculum with mm blades. Miniature frame ideal for deep set eyes and small orbital structures....
Solid 4 mm blades. Locking thumb. Dull finish. Holes in bar decrease weight of speculum....
Medicine Products: