Navigation Links
Anti-tumor necrosis factor treatment does not increase cancer Risk in RA patients
Date:10/28/2009

A recent study by Swedish researchers found that rheumatoid arthritis (RA) patients did not experience an elevated cancer risk in the first 6 years after starting anti-tumor necrosis factor (TNF) therapy. The research team, led by Johan Askling, M.D., Ph.D., from Karolinska University Hospital in Stockholm, Sweden assessed the short-term and medium-term cancer risk for RA patients using anti-TNF therapies: infliximab, adalimumab, and etanercept. Details of the study appear in the November issue of Arthritis & Rheumatism, a journal of the American College of Rheumatology published by Wiley-Blackwell.

TNF is a cytokine (substance secreted by immune system cells) that regulates the body's immune system and is involved in inflammation. TNF inhibitors (or TNF blockers) are a class of therapies used to reduce inflammation in chronic inflammation such as RA. The common immunosuppressant drugs and those included in the study are Remicade, HumiraTM, and Enbrel. As these therapies are used to treat chronic inflammatory illnesses, the long-term inhibition of TNF raises concerns for increased risk of infections and cancer.

This study, one of the largest and longest population-based assessments of cancer risks associated with immunosuppressive therapy, included data from several Swedish databases including the Biologics Register, the Cancer Register, and the Early RA Register. Researchers identified and analyzed data from 6,366 patients who started anti-TNF therapy between January 1999 and July 2006. Data from patients using TNF inhibitors was compared with other groups of RA patients61,160 not taking medication, 4015 using methotrexate (the gold standard in RA treatment) and 4,015 taking combinations of disease-modifying anti-rheumatic drugs (other than TNF inhibitors).

Results show there were 240 first primary cancers diagnosed during the 25,693 person-years of follow-up in the patients using anti-TNF therapy who had no histor
'/>"/>

Contact: Dawn Peters
medicalnews@wiley.com
781-388-8408
Wiley-Blackwell
Source:Eurekalert

Page: 1 2

Related medicine news :

1. CD200 stifles anti-tumor immunity
2. A new light on the anti-tumor mechanisms of Scutellaria barbata
3. Mersanas Second Development Candidate, XMT-1107, Shows Superior Pharmacokinetics and Anti-Tumor Activity in Studies Presented at American Association of Cancer Research Meeting
4. Short-term stress enhances anti-tumor activity in mice, Stanford study shows
5. Massive necrosis after trans-catheter treatment is more common in the presence of tumor capsule
6. Popular osteoporosis drugs triple risk of bone necrosis
7. Link between treating osteoporosis with bisphosphonates and incidence of bone necrosis examined
8. Effect of tumor necrosis factor a inhibitors on heart failure risk in RA Patients
9. USC dentist links Fosomax-type drugs to jaw necrosis
10. Orthopedic Surgeon Dr. Marc W. Hungerford, a Leading Expert in Field of Avascular Necrosis, Now at Baltimore's Mercy Medical Center
11. Amgen and Wyeth Statement on FDA Announcement About Tumor Necrosis Factor (TNF) Blockers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/5/2015)... 05, 2015 Okyanos, the leader in ... today. The study was conducted to determine the emotional ... osteoarthritis and sports-related injuries have had on those ... the most prevalent symptom reported at 73%, followed by ... standing and bending over. Over half of respondents, 56%, ...
(Date:5/5/2015)... 05, 2015 On May, 5, 2015, My ... musician Irene Rose about alternatives for youngsters to do this ... you get the idea for starting a summer camp and ... an entertainment company called Once Upon a Party and I ... through songs and even scripture. We play games, sing, and ...
(Date:5/5/2015)... On April 8th, 2015, at the famous Avalon ... Durkin Entertainment’s “RockNRolla” EcoLuxe Lounge, a daylong event organized ... placement in TV and film. , A gathering ... sound and socially conscious products and services, the EcoLuxe ... appearances at various awards ceremonies and festivals each year, ...
(Date:5/5/2015)... May 05, 2015 For the growing list ... series of data loggers. This data logger series ... electronic components for optimum performance throughout exposure to high temperatures ... loggers are capable of storing up to 32,700 readings ... life of one year or longer. All data loggers in ...
(Date:5/5/2015)... (PRWEB) May 05, 2015 Don’t have ... money for a fitness membership? Don’t know which workout ... these obstacles in order to help members achieve their ... Live Streaming Fitness, an educational, caused-based wellness company, today ... live streaming fitness classes led by certified trainers, nutritional ...
Breaking Medicine News(10 mins):Health News:Okyanos Study Finds Orthopedic Patients Plagued with Pain 2Health News:Okyanos Study Finds Orthopedic Patients Plagued with Pain 3Health News:My Positive Perspective Hosts Episode Informing People of a True Princess Summer Camp With Irene Rose 2Health News:Choices Recovery Mishawaka Talks About Overcoming Adversity with Actor Matthew Ziff at the “RockNRolla Movie Awards” EcoLuxe Lounge 2Health News:MadgeTech High Temperature Data Logger Series Expands for Growing Demands 2Health News:MadgeTech High Temperature Data Logger Series Expands for Growing Demands 3Health News:MadgeTech High Temperature Data Logger Series Expands for Growing Demands 4Health News:MadgeTech High Temperature Data Logger Series Expands for Growing Demands 5Health News:MadgeTech High Temperature Data Logger Series Expands for Growing Demands 6Health News:Live Streaming Fitness Creates Industry Shift by Bringing Fitness, Nutrition and Cooking Classes to Smart Devices 2Health News:Live Streaming Fitness Creates Industry Shift by Bringing Fitness, Nutrition and Cooking Classes to Smart Devices 3
... Canada are raising a hue and cry over inadequate facilities in ... ill-equipped and many a times patients have to be treated in ... the B.C. Nurses' Union president Deb McPherson said that the status ... have no privacy and no direct access to a washroom, or ...
... reporting that the traditional method of assessing the heart ... danger //of missing one-third of women who are predisposed ... ,Roger Blumenthal, M.D., an associate professor and director ... Hopkins University School of Medicine and its Heart Institute ...
... The health services in Australia’s Townsville will be revolutionized after ... the James Cook University (JCU).// A rural medical school has ... JCU. The University’s new clinic will cost A$ 3 million, ... This will serve to give them experience with regard medicine ...
... to Food science and consumer acceptance in Norway the ... do experts to cheese.// ,The food compared was ... expert dairy assessors. The rating was based on reaction ... was difference of opinion in both factions. As a ...
... Researchers from the Pennsylvania State University are trying to determine ... the zebra fish. The team led by Mark Shriver studied ... change in their key gene plays a major role in ... of Science, may not only help explain why people of ...
... against cancer focusing at the molecular and genetic levels, ... coming under increasing scrutiny.// Now scientists at the University ... these supporting cells are indeed key players in the ... ,These findings were arrived at after studying a ...
Cached Medicine News:Health News:Calcium Levels Could Indicate Future Heart Disease Risk 2Health News:Cancer Cells Trigger Supporting Cells to Turn Cancerous 2
(Date:5/5/2015)... Big Market Research presents a detailed analysis of the ... ( France , Germany , ... Japan . Current scientific views on the Hepatitis ... test volume and sales forecasts by country for HAV NAT, HBV ... HBc Ag, HBe Ag, and ALT/SGPT tests performed in the following ...
(Date:5/5/2015)... , May 5, 2015 ... ( http://www.oramed.com ), a clinical-stage pharmaceutical company focused ... announced today that the company will present at ... Oppenheimer 16th Annual Israeli Conference , ,Date:   ... Nadav Kidron , Chief Executive Officer ,Time: ...
(Date:5/5/2015)... -- E-QURE (Electric Quick Ulcer Remedy) Corp. ... of innovative medical devices in the field of advanced ... and the investment community, covering 2014 - 2015 business ... Bioelectrical Signal Therapy™ (BST) Device for advanced hard-to-heal wounds ... as its plans for commercialization and sale of the ...
Breaking Medicine Technology:2015 Opportunities in the Global Hepatitis Diagnostic Testing Market: Big Market Research 22015 Opportunities in the Global Hepatitis Diagnostic Testing Market: Big Market Research 3Oramed to Present at Upcoming Conferences 2Oramed to Present at Upcoming Conferences 3E-QURE Corp. Issues 2014 - 2015 Update to Shareholders 2E-QURE Corp. Issues 2014 - 2015 Update to Shareholders 3E-QURE Corp. Issues 2014 - 2015 Update to Shareholders 4E-QURE Corp. Issues 2014 - 2015 Update to Shareholders 5
... Volcano Corporation (NASDAQ: VOLC ) today ... year, the Massachusetts Superior Court rejected claims by ... Medical, that Volcano Corporation and its wholly-owned subsidiary, ... for use in the development of Volcano,s Optical ...
... Tigris Pharmaceuticals, Inc., today announced enrollment of its first ... AFP-464 (aminoflavone prodrug) with or without Faslodex® (fulvestrant) in ... be used to pre-screen patients for a biomarker called ... predict sensitivity to AFP-464. It is ...
Cached Medicine Technology:Statement From Volcano Corporation on Latest St. Jude Lawsuit 2Tigris Pharmaceuticals Initiates Randomized Phase 2 Study of AFP-464 in ER-Positive Breast Cancer Patients 2Tigris Pharmaceuticals Initiates Randomized Phase 2 Study of AFP-464 in ER-Positive Breast Cancer Patients 3
Glucose tubes contain an anti-coagulant and a stabiliser. The tubes are ideal for glucose and lactate determinations....
...
BD Vacutainer® Specialty Tubes - Trace Element - Plastic...
... The inner wall of the serum tube ... these particles activate the coagulation process. Serum ... in the base of the tube; during ... between the serum and the blood cells. ...
Medicine Products: