Navigation Links
Anti-spasticity medications need further research
Date:1/27/2010

Only a few anti-spasticity medications used for children with cerebral palsy are backed by sufficient research to justify their use, according to a new review of scientific literature headed by a UT Southwestern Medical Center neurologist and conducted by a national panel of interdisciplinary experts nationwide.

The findings prompted the American Academy of Neurology to release a new practice guideline on effective treatments. Dr. Mauricio Delgado-Ayala, professor of neurology at UT Southwestern is lead author of the guideline, which appears in the Jan. 26 issue of the academy's journal, Neurology.

Botulinum toxin type A, sold under the brand names Botox and Dysport, is effective and generally safe to relieve spasticity, the researchers found. The drugs diazepam (Valium) and tizanidine (Zanaflex, Sirdalud) can also be used, although they carry more risks.

The researchers found insufficient evidence on whether other commonly used drugs are effective or safe.

A statement by the academy said that practice guidelines are intended to keep neurologists up to date on clinical research and improve medical treatment; they are not intended as hard-and-fast rules.

"The guideline identified a need for more research on most drugs used to treat generalized spasticity," said Dr. Delgado-Ayala. "These drugs might work and be safe, but that needs to be proved.

The lack of evidence does not mean that existing treatment methods are not effective and safe, but it should make us pause and realize that more research needs to be conducted."Most of the medications we use in children were originally studied in adults," Dr. Delgado-Ayala said. "We need to know more about how these medications work in the body, and the doses for best results and least side effects, not only to reduce spasticity but also to improve quality of life."

About 10,000 babies a year in the U.S. are born with cerebral palsy. Cerebral palsy comprises several types of movement disorders, sometimes accompanied by learning disorders, epilepsy and other conditions. The most common characteristic is spasticity, in which muscles tense and flex uncontrollably.

Botox and other drugs can be legally prescribed to treat spasticity, but this use is considered "off-label" because they have not been specifically approved by the Food and Drug Administration for that condition.

For the practice guideline panel, the American Academy of Neurology enlisted five pediatric neurologists, two developmental pediatricians, one pediatric physiatrist, one pediatric orthopedist and one adult neurologist. The panelists examined 218 research studies, all of which appeared in peer-reviewed journals and involved cerebral palsy patients under the age of 19, with at least nine patients studied. The panel made recommendations according to the level of evidence found.

Overall, the literature review identified a large "research gap," showing that the effectiveness, mechanism and safety of many drugs has not been adequately studied in children, Dr. Delgado-Ayala said.

"There is an urgent need to develop new drugs to treat spasticity in general," he said. "There has not been a new drug approved for spasticity by the FDA in more than 10 years."


'/>"/>

Contact: Aline McKenzie
aline.mckenzie@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert

Related medicine news :

1. A novel computational model -- how Parkinsons medications affect learning and attention
2. First Oral Medications For MS Show Promise
3. Monitoring of high-risk medications unchanged despite FDA warnings
4. Urinary Incontinence Rates Increase Worldwide As Awareness Grows About Treatment Options: Urethral Slings Are Popular Alternatives When Medications Fail
5. Pathological Gambling May Be Successfully Treated With Medications for Substance Addiction
6. Study highlights lack of patient knowledge regarding hospital medications
7. TheBody.com Launches My Health Tracker, Enabling HIV-Positive Patients to Track Lab Results, Medications and Supplements
8. Sinusitis Treatment Using Nebulized Medications to Treat Sinusitis Rather than Sinus Surgery
9. Greater certainty in monitoring 3 therapeutic medications is facilitated by new CRMs
10. Pelosi Applauds Provisions in Health Bill to Improve Access to Care, Medications for People Living With HIV/AIDS
11. Antipsychotic Medications Cause Substantial Weight Gain in Children and Adolescents, According to Scientists at the Feinstein Institute for Medical Research and Zucker Hillside Hospital
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... 2017 , ... Apple Rehab Shelton Lakes , which specializes in the ... facility as part of a disaster drill on October 3rd. , Apple Rehab participated ... Emergency Manager, as well as the Connecticut Long Term Care Mutual Aid Plan ...
(Date:10/13/2017)... ... October 13, 2017 , ... The Visiting Nurse Association ... Featuring a collection of specialty vendors and unique items from across the nation, this ... health and wellness services offered by the VNA. The boutique will be open ...
(Date:10/13/2017)... ... October 13, 2017 , ... Global Healthcare Management’s 4th Annual Kids ... Milford, NJ. This free event, sponsored by Global Healthcare Management’s CEO, Jon Letko, ... run is geared towards children of all ages; it is a non-competitive, non-timed event, ...
(Date:10/13/2017)... ... October 13, 2017 , ... ... viewers the lowdown on sciatica in a new episode of "Success Files," which ... current events and innovation and investigates each subject in-depth with passion and integrity. ...
(Date:10/13/2017)... ... ... Journey: From the Mountains to the Mission Field”: the story of a missionary couple ... From the Mountains to the Mission Field” is the creation of published author, Carole ... and currently teaches a class of ladies at her church, which she has taught ...
Breaking Medicine News(10 mins):
(Date:10/4/2017)... 4, 2017  South Korean-based healthcare product Development Company ... "cprCUBE" on Kickstarter. The device will educate the user ... with better efficiency compared to the dated and pricey ... on efficacy of the compression for a more informed ... goal to raise $5,000. ...
(Date:10/4/2017)... Mass. , Oct. 4, 2017 ... of single-use, self-contained, illuminating medical devices, today announced ... National Health Surveillance Agency (or Agência Nacional de ... The first single-use, cordless surgical retractor with integrated ... provides optimal access, illumination and exposure of a ...
(Date:10/2/2017)... -- Eli Lilly and Company (NYSE: LLY ) ... of 2017 on Tuesday, October 24, 2017. Lilly will ... the investment community and media to further detail the ... begin at 9 a.m. Eastern time. Investors, media and ... the conference call through a link that will be ...
Breaking Medicine Technology: