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Anti-sense might make sense for treating liver cancer
Date:1/3/2012

ne of the controls.

  • The antisense oligonucleotide significantly reduced levels of miR-221 in both tumor and normal liver samples.

  • Treatment with the antisense oligonucleotide caused a three-fold increase in the activity of three important tumor-suppressor genes that are blocked by miR-221 in liver cancer. (The tumor suppressors were p27, p57 and PTEN.)

    "Overall, this study provides proof-of-principle for further development of microRNA-targeted therapies for hepatocellular carcinomas," Schmittgen says.


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  • Contact: Darrell E. Ward
    Darrell.Ward@osumc.edu
    614-293-3737
    Ohio State University Medical Center
    Source:Eurekalert

    Page: 1 2

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