Navigation Links
Anti-psychotic medications offer new hope in the battle against glioblastoma
Date:3/7/2014

Researchers at the University of California, San Diego School of Medicine have discovered that FDA-approved anti-psychotic drugs possess tumor-killing activity against the most aggressive form of primary brain cancer, glioblastoma. The finding was published in this week's online edition of Oncotarget.

The team of scientists, led by principal investigator, Clark C. Chen, MD, PhD, vice-chairman, UC San Diego, School of Medicine, division of neurosurgery, used a technology platform called shRNA to test how each gene in the human genome contributed to glioblastoma growth. The discovery that led to the shRNA technology won the Nobel Prize in Physiology/Medicine in 2006.

"ShRNAs are invaluable tools in the study of what genes do. They function like molecular erasers," said Chen. "We can design these 'erasers' against every gene in the human genome. These shRNAs can then be packaged into viruses and introduced into cancer cells. If a gene is required for glioblastoma growth and the shRNA erases the function of that gene, then the cancer cell will either stop growing or die."

Chen said that one surprising finding is that many genes required for glioblastoma growth are also required for dopamine receptor function. Dopamine is a small molecule that is released by nerve cells and binds to the dopamine receptor in surrounding nerve cells, enabling cell communication.

Abnormal dopamine regulation is associated with Parkinson's disease, schizophrenia, and Attention Deficit Hyperactivity Disorder. Because of the importance of dopamine in these diseases, drugs have been developed to neutralize the effect of dopamine, called dopamine antagonists.

Following clues unveiled by their shRNA study, Chen and his team tested the effects of dopamine antagonists against glioblastoma and found that these drugs exert significant anti-tumor effects both in cultured cells and mouse models. These effects are synergistic when combi
'/>"/>

Contact: Jackie Carr
jcarr@ucsd.edu
619-543-6163
University of California - San Diego
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. New Risperdal Lawsuit Filed in Pennsylvania Litigation; Alleges Male Breast Growth Injuries Caused by Anti-Psychotic Medication, Bernstein Liebhard LLP Reports
2. Blood pressure medications given right after stroke not beneficial, study finds
3. MIT robot may accelerate trials for stroke medications
4. Fresno California's Hear for Life Hearing Aid Centers Publishes Warnings about Medications that Lead to Hearing Loss
5. Audiologists at American Hearing & Balance in Marina del Rey CA Educate Consumers About Everyday Medications That Cause Hearing Loss
6. Bernstein Liebhard LLP Launches New GranuFlo Lawsuit Website for Individuals Allegedly Injured by Recalled Dialysis Medications
7. Effect of reducing blood pressure with medications immediately following ischemic stroke
8. Watchful Waiting Can Do the Job of BPH Medications For Some Men, From the November 2013 Harvard Men's Health Watch
9. Racial difference in blood clotting warrants a closer look at heart attack medications
10. Mothers immunosuppressive medications not likely to put fetus at risk
11. Pain Management Therapeutics Market to 2019 - Impact of Patent Expiries Offset by Demand for Neuropathic and Rheumatoid Pain Medications and Strong Pipeline
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Anti-psychotic medications offer new hope in the battle against glioblastoma
(Date:5/27/2015)... ABILENE, Texas (PRWEB) May 27, 2015 ... addition of three FDA-approved dermal filler treatments in Abilene, ... designed to reduce the appearance of glabellar lines, better ... lines. Belotero Balance® is designed to treat smoker’s ... mouth to the chin, while Radiesse® improves the appearance ...
(Date:5/27/2015)... (PRWEB) May 27, 2015 Coco Libre announced ... be able to reach for Organic Coconut Water to quench ... will be available at VIP areas, artist greenrooms, corporate skyboxes ... available at area hotels and on festival shuttle buses. ... this year,” said Noa Elan, Director of Strategic Partnerships for ...
(Date:5/27/2015)... Arizona (PRWEB) May 27, 2015 Genius ... of their advanced programmatic marketing technology, they have boosted ... advertising support on a regional level for seven Utah-based ... marketing was through television and radio media. In 2014 ... with the help of Genius Monkey , shifted ...
(Date:5/27/2015)... May 27, 2015 With a prevalently ... poll conducted during the "ACA - Controlling the Chaos" ... 75% are currently in the process of researching ... were confidently prepared for the reporting mandates. , According ... the webinar, those who are currently vetting ACA reporting ...
(Date:5/27/2015)... May 27, 2015 Decorview , ... America, is offering free design advice to homeowners looking ... , “Light pollution caused by streetlights, outdoor signs, ... restless night’s sleep, said Kim Rush, VP of sales ... cities across North America with recently installed LED streetlights– ...
Breaking Medicine News(10 mins):Health News:The MedSpa at Hendrick Introduces Xeomin®, Belotero Balance® and Radiesse® Injectables 2Health News:Coco Libre Puts Organic Coconut Water on the Line-up at BottleRock Napa 2Health News:Genius Monkey Boosts Utah Honda Dealers Website Traffic 142% 2Health News:Employers are On Track for ACA Reporting According to Businessolver Poll 2Health News:Decorview Helps Homeowners Combat Light Pollution 2
... 10-page letter addressed to Donald Berwick, administrator of the ... The ACP strongly supports the intent of the ... potential of supporting such important care delivery goals as ... pleased that,the foundation of care under this payment model, ...
... Hartford Faculty Scholars Program has granted 11 geriatric ... development, mentorship, and support for projects that will improve healthy ... the awards this year is a partnership with the ... the current awardees are PhD-level social workers from the VA ...
... HealthDay Reporter , THURSDAY, June 2 (HealthDay ... regular exercise as part of the plan, don,t appear ... "It,s pretty clear low-carb is effective for weight ... clinical and research exercise physiology at the Johns Hopkins ...
... are evaluated for liver diseases such as hepatitis C ... the extent of disease progression. For patients who question ... alternatives options to consider. Elastography and serum markers are ... in the June issue of Hepatology , a ...
... , THURSDAY, June 2 (HealthDay News) -- Young children ... from anxiety, loneliness, low self-esteem and sadness, they experience ... new research suggests. Children do not fall behind ... period before their parents divorce, the study revealed. Instead, ...
... study from North Carolina State University shows that talking about ... transgender community. The finding may help efforts to promote safer ... and also sheds light on broader questions related to safer ... is the fact that we,re seeing evidence of devastatingly high ...
Cached Medicine News:Health News:Supportive of intent of ACO proposed rule, ACP expresses concern 2Health News:Supportive of intent of ACO proposed rule, ACP expresses concern 3Health News:Hartford Program issues geriatric social work awards, forms VA partnership 2Health News:Hartford Program issues geriatric social work awards, forms VA partnership 3Health News:Low-Carb, High-Fat Diets May Not Pose Risk to Arteries 2Health News:Low-Carb, High-Fat Diets May Not Pose Risk to Arteries 3Health News:Noninvasive diagnostics may offer alternative to liver biopsy for assessing liver fibrosis 2Health News:Divorce Can Hurt Kids' Math Scores, Friendships 2Health News:Divorce Can Hurt Kids' Math Scores, Friendships 3Health News:Safer sex: Study examines sexual communication in transgender community 2
(Date:5/27/2015)... and NEW YORK , May 27, ... - Over 70% Indonesian men (80 million) are ... annually due to smoking-related conditions; of these, 6% are ... vehicles in Jakarta do not ... is the fourth most populous country in ...
(Date:5/27/2015)... RUTHERFORD, N.J. , May 27, 2015  Cambrex Corporation ... Sargen , Executive Vice President and Chief Financial Officer, will ... 3, 2015 at 8:00 a.m. EDT in New ... and slide presentation can be accessed from the Cambrex website ... & Presentations", and a replay will be available for 90 ...
(Date:5/27/2015)... , May 27, 2015  Novartis will ... in 21 medicines and 11 investigational compounds across ... American Society of Clinical Oncology (ASCO) Annual Meeting, ... European Hematology Association (EHA), June 11-14. Data will ... cancer types, including melanoma, lung, breast, kidney and ...
Breaking Medicine Technology:Indonesia Respiratory Devices Market is Expected to Grow at a CAGR of 9% - Boosting Growth for Respiratory Disposables 2Indonesia Respiratory Devices Market is Expected to Grow at a CAGR of 9% - Boosting Growth for Respiratory Disposables 3Indonesia Respiratory Devices Market is Expected to Grow at a CAGR of 9% - Boosting Growth for Respiratory Disposables 4Novartis presents new data on 21 medicines and 11 investigational compounds at ASCO and EHA 2Novartis presents new data on 21 medicines and 11 investigational compounds at ASCO and EHA 3Novartis presents new data on 21 medicines and 11 investigational compounds at ASCO and EHA 4Novartis presents new data on 21 medicines and 11 investigational compounds at ASCO and EHA 5Novartis presents new data on 21 medicines and 11 investigational compounds at ASCO and EHA 6Novartis presents new data on 21 medicines and 11 investigational compounds at ASCO and EHA 7Novartis presents new data on 21 medicines and 11 investigational compounds at ASCO and EHA 8
... Ruschelit® PVC. 2 eyes, oral. ... patient age. X-ray opaque line. Graduated. ... access. Designed to reduce kinking of ... curvature. Thermosensitive Ruschelit® PVC adapts to ...
... PVC. 2 eyes, oral. Marked with ... X-ray opaque line. Graduated. Single use. ... reduce kinking of the tube by ... adapts to the anatomical situation at ...
... Slick Set® Tube with stylet inside. ... quality cuffed Rusch endotracheal tube with ... to use saving you time and ... coded for easy identification and has ...
Ruschelit® PVC. Murphy eye-nasoral. Black positioning ring. High volume/low pressure cuff. X-ray opaque line. Graduated. Single use....
Medicine Products: