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Anti-pain agent shrinks oral cancers, leaves healthy tissues alone
Date:7/23/2014

been tested. But many patients with oral cancer have disease that has spread. "We would like to be able to deliver this therapy systemically to target metastatic disease," Dr. Gonzales said. "Our laboratory is working with the Center for Innovation in Drug Discovery, a partnership between the Health Science Center and UTSA, to develop novel drugs that are similar to capsazepine with improved efficacy for the purpose of systemic administration to treat tumors that are inaccessible to local injection or that have metastasized."

At-risk patients

Randal A. Otto, M.D., F.A.C.S., professor and chairman of the Department of Otolaryngology-Head & Neck Surgery in the School of Medicine, said: "These tumors, if identified and treated early, are definitely curable. Unfortunately, most patients present with advanced disease with the cancer involving critical structures. This markedly decreases the chance for cure and dramatically increases the risks associated with treatment. Anything that selectively attacks the tumor while not injuring the normal tissues can only help the patient."

Acknowledgments

This work is supported by American Cancer Society Mentored Research Scholar Grant MRSG-11-061-01-PCSM and in part by Clinical & Translational Science Award (CTSA) Grant UL1TR001120 and the National Cancer Institute P30 Grant CA054174 to the Cancer Therapy & Research Center at the UT Health Science Center at San Antonio.


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Contact: Will Sansom
sansom@uthscsa.edu
210-567-2579
University of Texas Health Science Center at San Antonio
Source:Eurekalert

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