Navigation Links
Anti-fungal drug offers great benefits to some with severe asthma
Date:12/28/2008

Some patients with severe asthma who also have allergic sensitivity to certain fungi enjoy great improvements in their quality of life and on other measures after taking an antifungal drug, according to new research from The University of Manchester in England.

The findings were reported in the first issue for January of the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine.

"We knew that many people with severe asthma are sensitized to several airborne fungi which can worsen asthma without overt clinical signs. The question was: does antifungal therapy provide any clinical benefit," said David Denning, F.R.C.P., F.R.C.Path., professor of medicine and medical mycology at The University of Manchester and lead investigator of the study.

In 2006, the most recent year for which official statistics are available, there were more than 16 million adults with self-reported asthma in the U.S.; about 20 percent of them have severe asthma.

A small number of severe asthmaticsabout one percent are known to have a syndrome called allergic bronchopulmonary aspergillosis, an extreme allergy to Aspergillus fumigatus fungus that is associated with the long-term colonization of their respiratory tracts with the fungus. But many more 20 to 50 percent are sensitized to a variety of fungi without showing overt clinical signs or demonstrable colonization. It is these patients with severe asthma with fungal sensitization, or "SAFS", as the researchers named the syndrome, who are most likely to enjoy marked improvement with the antifungal therapy.

In the prospective double-blind study, 58 patients with severe asthma and allergic sensitivity to at least one of seven different common fungi (confirmed by a skin-prick test and/or an IgE blood test for the study) were randomized to receive either an oral dose of itraconazole (200mg twice a day) or a placebo.

After 32 weeks of treatment, 18 of the 29 patients (62 percent) who were randomized to receive the drug experienced significant improvements on their Asthma Quality of Life Questionnaires, and in runny nose and morning lung function. However, 11 of the patients who received the drug left the trial before completion, some citing side effects that included nausea, breathlessness and muscle weakness. Unfortunately, four months after stopping antifungal treatment, symptoms had returned.

"This study indicates that fungal allergy is important in some patients with severe asthma, and that oral antifungal therapy is worth trying in difficult-to-treat patients. Clearly itraconazole will not suit everyone and is not always helpful, but when it is the effect is dramatic," said Dr. Denning. "These findings open the door to a new means of helping patients with severe asthma, and raise intriguing questions related to fungal allergy and asthma."

John Heffner, M.D., past president of the ATS, reflected that the recent Severe Asthma Research Program report describes severe asthma as a entirely different form of the disease. "Patients with severe asthma may have unique triggers for bronchospasm, which remain unidentified. This study suggests that colonization with fungal species may generate immunologic responses in patients with asthma that perpetuate airway inflammation and blunt the effectiveness of drug therapy. One can't help but wonder if antifungal therapy would benefit all severe asthmatics regardless of sensitivity to fungi."


'/>"/>

Contact: Keely Savoie
ksavoie@thoracic.org
212-315-8620
American Thoracic Society
Source:Eurekalert

Related medicine news :

1. Your Chemist Shop Offers Patients a Revolutionary Alternative to Other Hair Loss Treatments for Both Men and Women
2. STERIS Isomedix Services Offers Medical Device Sterilization Seminar
3. NeedyMeds.org Offers Information on Drug Discount Coupon
4. Fresho.Com Offers Efficient Job Postings for Employers and Recruiters
5. Just in Time for the Holiday Rush, Braintree Stylist Bruce Fisher Offers Holiday Style & Beauty Tips
6. Physical therapy offers evidence-based solution to musculoskeletal pain
7. True Data Offers New Special Leasing Rates on Dialogic, Samsung, & Vertical Communications Products
8. How to Change Someone You Love Seminar Offers Help to Those Who Feel Powerless in the Face of Addiction
9. Partnership for Prevention Offers Health Reform Recommendations to Congress
10. Reid Supply Offers Free Educational Technical Resource Guides
11. All Nursing Schools Offers Continuing Education Resources
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/21/2017)... ... ... Hawkins, Pastor and Overseer at The House of Yahweh in Abilene, Texas, wrote an open ... with solution to peace plan. Yisrayl says war has never brought peace and he knows ... Creator Himself. , Yisrayl says war drums are beating all over the media and ...
(Date:4/21/2017)... GA (PRWEB) , ... April 21, 2017 , ... During ... in Augusta, Georgia. , This festival offers entertainment for everyone — from the ... Heart Garden Festival is a very high quality event held in a grand venue, ...
(Date:4/21/2017)... ... April 21, 2017 , ... ... news for older shoulder replacement patients; post-operative recovery just might be even better ... of patients presenting with osteoarthritis following surgery: 262 patients under 65 and 103 ...
(Date:4/21/2017)... Dublin, Ireland (PRWEB) , ... April 21, 2017 , ... ... the dramatic increase in the number of bed bug infestations over the 5-year period. ... management companies was from the treatment of bed bug infested properties. , The health ...
(Date:4/21/2017)... (PRWEB) , ... April 21, 2017 , ... In a ... Area , a summer camp for kids in Dana Point, parents are challenged to ... out. The writers caution parents to find age appropriate activities that both reinforce their ...
Breaking Medicine News(10 mins):
(Date:4/19/2017)... LONDON , April 19, 2017 ... to stimulate an immune response in pets such ... vaccine products are of various types such as ... Vaccines, Toxoid Vaccines, DNA Vaccines and Recombinant Vaccines. ... such as virus or bacteria, which have been ...
(Date:4/19/2017)... OAKS, Calif. , April 19, 2017 /PRNewswire/ ... industrial buildings it is developing at Conejo Spectrum ... , to Atara Biotherapeutics, Inc. , ... with severe and life-threatening diseases that have been ... on allogeneic T-cell therapies for cancer, autoimmune and ...
(Date:4/18/2017)... -- Viverae ® , a leader in workplace wellness ... ® Watson Campaign Automation, implementing behavioral messaging within ... personalized experience. Through digital engagement, the platform prompts members ... time. The enhanced experience drives engagement by focusing on ... are in their journey to health. ...
Breaking Medicine Technology: