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Anti-estrogen drug therapy reduces risk of invasive breast cancer in older women
Date:6/10/2008

e detail in order to investigate the specific types and stages of breast cancer affected by raloxifene, as well as the timing of its action and the types of patients it can help.

"In this study, we looked at whether raloxifene would be more effective in some subgroups of women than others, but found that the relative benefit was the same, regardless of breast cancer risk," said Grady. "Like any therapy, the risk needs to be balanced with the side effects, which for raloxifene include blood clots and fatal stroke.

But these findings are important because few drugs actually reduce the risk of breast cancer." noted Grady. "Also raloxifene has been on the market for nearly a decade with good, long term safety data," said Barrett-Connor.

Researchers say women who would have the best risk-benefit ratio would be those at high risk of breast cancer, who have a 30 to 50 percent chance of getting breast cancer in the next five to ten years, and low risk of venous thrombosis and stroke. A reduced risk of spine fractures would be an additional benefit.


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Contact: Kim Edwards
kedwards@ucsd.edu
619-543-6163
University of California - San Diego
Source:Eurekalert

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