Navigation Links
Anti-epilepsy drug risk on cognitive function for unborn children
Date:7/21/2009

LIVERPOOL, UK 21 July 2009: Interim results of a study being conducted by scientists at the University of Liverpool suggest that children aged three years and younger, who are born to women taking the anti-epileptic drug sodium valproate whilst pregnant, are likely to have an IQ of six to nine points lower than average.

The research, in collaboration with Emory University in the US and the Central Manchester University Hospitals NHS Foundation Trust, tested more than 300 three-year-olds in the UK and US, whose mothers took one of four anti-epilepsy drugs (AEDs) whilst pregnant. The preliminary findings suggest that children exposed to the drug sodium valproate had lower IQ results than children exposed to other AEDs, regardless of the mother's IQ. The results also took dosage, duration of pregnancy and mother's consumption of folic acid whilst pregnant, into account.

Professor of Clinical Neuropsychology at the University, Gus Baker, said "Our research looked at how exposure to sodium valproate and other AEDs in the womb affected children's everyday life in particular their IQ, memory and language abilities from one to six years of age."

Around 5,000 women with epilepsy become pregnant every year in the UK and the majority of these, including those on AEDs, will experience uncomplicated pregnancies and births. Previous research conducted by the team has already shown that children exposed to AEDs such as sodium valproate in the womb are more likely to suffer birth defects characterised by heart malformations, dysmorphic features and minor limb deformities.

Professor Baker added: "The answer is not as simple as to take women off AEDs altogether as the effects of suffering a seizure can also pose a risk for both mother and unborn child. It is vital that the research is now used to educate women with epilepsy before they start to plan for a family. Women need to be aware of the risks so that they can make informed choices with the help and advice of experts. It is also important that women do not stop taking AED treatment without taking advice from their medical practitioner."

"It is important to stress that sodium valproate is used globally and it has a favourable safety profile for all adult patients who use it. It has a range of pharmaceutical uses including bipolar disorder, migraine, epilepsy, and in adults sodium valproate is extremely effective."


'/>"/>

Contact: Kate Spark
kate.spark@liv.ac.uk
44-151-794-2247
University of Liverpool
Source:Eurekalert

Related medicine news :

1. UCB Announces Positive Results From Phase II Clinical Trial of Investigational Anti-Epilepsy Drug Brivaracetam
2. Lack of sleep among new school-goers leads to behavioral, cognitive problems
3. Low level of neuronal receptor linked to mild cognitive impairment and Alzheimers disease
4. Cognitive Activities Protect Against Alzheimers -- Social and Physical Activities Not Enough
5. Potential new approach to treat cognitive impairments in schizophrenia
6. Cognitive deficits lead to loss of self among cancer patients
7. Research links diet to cognitive decline and dementia
8. First Cognitive Training to Demonstrate Immediate Generalizability Through Standardized Assessments of Memory
9. New research on aging and cognitive training presented at GSAs Annual Meeting
10. Hypertension Linked to Risk of Mild Cognitive Impairment
11. Rhode Island Hospital to study driving ability of cognitively impaired elders
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/29/2016)... Francisco, CA (PRWEB) , ... April 29, 2016 ... ... released fertility clinic data for 2014. Each year, reproductive endocrinologists are required to ... and SART, the main organization of professionals dedicated to the practice of assisted ...
(Date:4/29/2016)... ... April 29, 2016 , ... In its efforts of ... Services continues its successful franchise development and expansion as it welcomes Ferdie Vasquez of ... and administrative experience in his 32 years of working in various industries. He ...
(Date:4/28/2016)... ... 28, 2016 , ... The Dentists Insurance Company ... a letter of intent with Moda to acquire Dentists Benefits Insurance ... Started by dentists 36 years ago, TDIC focuses exclusively on supporting the dental ...
(Date:4/28/2016)... ... April 28, 2016 , ... CastCoverz!, America’s #1 trusted brand ... country's oldest waterproof cast protector . As the largest one-stop, orthopedic shop, ... of daily, night, weatherproof and waterproof covers for most orthopedic devices, including but ...
(Date:4/28/2016)... ... April 28, 2016 , ... The ARRS 2016 ... medical professionals from around the globe who attended a week’s worth of cutting-edge ... April 17 included the introduction of the 2016 ARRS Distinguished Educator, Dr. Gerald ...
Breaking Medicine News(10 mins):
(Date:4/28/2016)... , April 28, 2016   Acsis , a ... that leading IT market research and advisory firm IDC ... the IDC MarketScape: Worldwide Pharmaceutical Track and Trace Software ... report provides an assessment of the capabilities and business ... trace software market. Logo - http://photos.prnewswire.com/prnh/20160427/360791LOGO ...
(Date:4/28/2016)... , April 28, 2016 TapImmune,Inc. ... of innovative peptide and gene-based immunotherapeutics and vaccines for the ... be presenting at the 3rd Annual Growth Capital Expo ... th , 2016 at Caesars Palace in Las Vegas, Nevada.  ... on Wednesday, May 4 th by Dr. John ...
(Date:4/27/2016)... April 27, 2016  Hologic, Inc. (Nasdaq: ... results for the fiscal second quarter ended March ... of $0.24 increased 41.2%, and non-GAAP diluted EPS ... increased 5.8% on a reported basis, and 6.3% ... "We posted another good quarter, highlighted by 14.6% ...
Breaking Medicine Technology: