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Anti-dsDNA, surface-expressed TLR4 and endosomal TLR9 cooperate to exacerbate lupus
Date:6/12/2014

in addition to anti-dsDNA, signaling pathways triggered by simultaneous activation of surface-expressed TLR4 and endosomal TLR9 can promote the progression of SLE. These results suggest that simultaneous targeting of anti-dsDNA, TLR4 and 9 may be a potential therapy for SLE.

Dr. Steven R. Goodman, Editor-in-Chief of Experimental Biology and Medicine, said "These studies in transgenic mice offer new concepts for affecting immune tolerance and reducing SLE disease progression as future therapeutics are developed."


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Contact: Kuang-Hui Sun
khsun@ym.edu.tw
Society for Experimental Biology and Medicine
Source:Eurekalert

Page: 1 2

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