Navigation Links
Anti-cancer drug viewed as possible Alzheimer's treatment doesn't work in UF study
Date:5/23/2013

GAINESVILLE, Fla. An anti-cancer drug about to be tested in a clinical trial by a biomedical company in Ohio as a possible treatment for Alzheimer's disease has failed to work with the same type of brain plaques that plague Alzheimer's patients, according to results of a study by University of Florida researchers.

David Borchelt, Ph.D., a professor of neuroscience affiliated with the Evelyn F. and William L. McKnight Brain Institute of the University of Florida, emphasized the importance of verifying promising research results before investing in clinical studies or testing potential therapies in people. Bexarotene has known side effects that include effects on the liver, blood and other metabolic systems.

"We wanted to repeat the study to see if we could build on it, and we couldn't," he said. "We thought it was important that something like this, which got a lot of publicity and patients were immediately looking to try to get access to this drug, that it was important to publish the fact that we couldn't reproduce the most exciting part of the study. Maybe there should be some caution going forward in regard to patients."

Borchelt and Kevin Felsenstein, Ph.D., an associate professor of neuroscience, said a drug called bexarotene that their team orally administered to mice did not reduce amyloid plaques, waxy buildups on the brain that are a key culprit in Alzheimer's disease. Their findings will be published in the May 24, 2013 issue of the journal Science magazine, with two additional articles detailing similar results from other researchers.

The research follows up on a 2012 Science article that claimed bexarotene had reversed Alzheimer's-like symptoms in mice afflicted with the plaques. Authors of that study also administered the drug orally.

The paper "indicated that with as little as three days of treatment, they basically cleared the amyloid deposits from these animals, as well as restored cogn
'/>"/>

Contact: Rossana Passaniti
passar@shands.ufl.edu
352-273-8569
University of Florida
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Moffitt Cancer Center researchers develop and test new anti-cancer vaccine
2. 1960s-era anti-cancer drug points to treatments for Lou Gehrigs disease
3. Specialized MRI scans assess value of anti-cancer chemotherapy long before tumors shown to shrink
4. First trial in humans of minicells: A completely new way of delivering anti-cancer drugs
5. Development of the first way to make large amounts of promising anti-cancer substance
6. Progress after recent breakthrough which opened new chapter in anti-cancer cell therapies
7. Overcoming resistance to anti-cancer drugs by targeting cell powerhouses
8. Study finds that patient education videos viewed before an operation may benefit patients
9. First Is Viewed as Best When Making Quick Decisions
10. Minimal Exercise Protects Senior’s Hearts According to Recent Study Reviewed By Projects for Natural Health Choices Inc.
11. New Report “17 Cheat Foods that Burn Fat” Reviewed by DietRecommendations.com
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/18/2015)... (PRWEB) April 18, 2015 “ ArcAngel ” ... which takes a look at the latest and coolest ... Joe Troohey, the host of AppWatch and technology expert, conducted ... a personal safety app. , In a turbulent world, ... help. Calling 911 should always be their first move, but ...
(Date:4/17/2015)... Heritage Woods of McLeansboro, a Gardant affordable ... Celebration on April 20 with a day full of ... and soul. , The community, which is located at ... of all incomes, including those on Medicaid, who need ... Week is observed every April and highlights the communities ...
(Date:4/17/2015)... April 17, 2015 ERGO-Pedic Products, LLC, ... introducing two new products to help a broader range ... pain relief are the second most common visitors to ... product, designed specifically to help relieve sitting pain. Then, ... and thousands of happy customers later, we began getting ...
(Date:4/17/2015)... Florida Hospital Wesley Chapel, Florida Hospital at ... were all selected as Top Workplaces in Tampa Bay. ... is ranked number one for large businesses according to ... in partnership with an independent research firm. Florida Hospital ... opened in October of 2012 with a vision of ...
(Date:4/17/2015)... In Defense of Christians (IDC) Executive Director ... April 15th, the European Parliament joined its voice with ... Armenian Genocide, “paying tribute, on the eve of the ... Armenian victims who perished in the Ottoman Empire.” ... this timely and needed recognition of a tragic episode ...
Breaking Medicine News(10 mins):Health News:A Personal Safety Application was Featured on NewsWatch Television 2Health News:Heritage Woods of McLeansboro Affordable Assisted Living to Celebrate Supportive Living Week 2Health News:Heritage Woods of McLeansboro Affordable Assisted Living to Celebrate Supportive Living Week 3Health News:Seat Cushion Company Credits Customer Driven Design For Two New Products 2Health News:Tampa Bay Times Selects Florida Hospital Wesley Chapel, Florida Hospital at Connerton Long Term Acute Care and Florida Hospital Carrollwood As Top Workplaces in Tampa Bay 2Health News:Tampa Bay Times Selects Florida Hospital Wesley Chapel, Florida Hospital at Connerton Long Term Acute Care and Florida Hospital Carrollwood As Top Workplaces in Tampa Bay 3Health News:Tampa Bay Times Selects Florida Hospital Wesley Chapel, Florida Hospital at Connerton Long Term Acute Care and Florida Hospital Carrollwood As Top Workplaces in Tampa Bay 4Health News:In Defense of Christians Condemns Armenian Genocide 2Health News:In Defense of Christians Condemns Armenian Genocide 3
... system of this mosquito is of great importance as scientists ... of viruses that cause yellow and dengue fevers ... genes that make up the immune system of the Aedes ... been identified. ,This study is the first of ...
... the airplane, is about to be connected, allowing travellers to ... off cell phones and fasten seatbelts are a familiar ... European company has found a way to make dialling safe ... ,"Cabin connectivity is here and GSM phone use is both ...
... a healthy diet rich in fish and nuts could be ... to prostate cancer, new US research indicates . A study ... Investigation found that omega-3 fatty acids found in the foods ... to the condition. Working with mice genetically engineered to develop ...
... an ancient retrovirus that infected chimps and other primates millions ... species is susceptible to HIV, said a study released Thursday. ... against a four-million-year-old virus, called Pan troglodytes endogenous retrovirus, or ... most retroviruses, it inserts its DNA into the genome of ...
... urate in the blood is linked to a reduced risk ... at the Harvard School of Public Health (HSPH), was led ... ,Urate is a normal component of blood, and although ... beneficial effects because it is a potent antioxidant. ...
... Thursday said that all villages affected by chikungunya fever ... spread awareness among people even as 17,000 suspected ... this year. ,'We have asked the nine chikungunya-affected ... National Rural Health Mission, we will provide Rs.10,000 each ...
Cached Medicine News:Health News:Aedes Agypti Mosquitos Immune System Revealed 2Health News:'Hi, can You Hear Me? I'm at 30,000 Feet' 2Health News:'Hi, can You Hear Me? I'm at 30,000 Feet' 3Health News:Ancient Viral Defense may Explain Susceptibility to HIV: Study 2Health News:High Urate Levels in Blood Linked to Reduced Parkinson's Risk 2Health News:Chikungunya-hit Villages to Get Funds to Fight Mosquitoes 2
(Date:4/17/2015)... -- Sigma-Aldrich Corporation (NASDAQ: SIAL ... company, today announced the opening of its ... Cell Culture Technical Center in Singapore.  Located at ... support to meet customer needs, leveraging the Company,s ... Technical Center will significantly enhance our ability to ...
(Date:4/16/2015)... , April 16, 2015 Mindray Medical ... manufacturer, and marketer of medical devices worldwide, announced ... and Exchange Commission an Annual Report on Form 20-F ... ended December 31, 2014. An electronic version of Mindray,s ... Mindray,s investor relations website at  http://ir.mindray.com  or  http://www.sec.gov ...
(Date:4/16/2015)... 16, 2015  Amgen (NASDAQ: AMGN ) today ... results on Tuesday, April 21, 2015, after the close ... followed by a conference call with the investment community ... Amgen will be Robert A. Bradway , chairman ... senior management team. Live audio of the ...
Breaking Medicine Technology:Sigma-Aldrich Expands Customer-Centric Model with Investments in Singapore That Localize World-Class Capabilities to Better Support Customers in Asia 2Sigma-Aldrich Expands Customer-Centric Model with Investments in Singapore That Localize World-Class Capabilities to Better Support Customers in Asia 3Sigma-Aldrich Expands Customer-Centric Model with Investments in Singapore That Localize World-Class Capabilities to Better Support Customers in Asia 4Sigma-Aldrich Expands Customer-Centric Model with Investments in Singapore That Localize World-Class Capabilities to Better Support Customers in Asia 5Mindray Files Annual Report on Form 20-F with the U.S. Securities and Exchange Commission 2Amgen Announces Webcast Of 2015 First Quarter Financial Results 2
... 5, 2011 Reportlinker.com announces that ... available in its catalogue: ... Assessments of Leading Suppliers ... This report provides industry executives with ...
... Oct. 5, 2011 Reportlinker.com announces ... is available in its catalogue: ... Dermatological Drugs, 7th Edition ... This Kalorama Information report details the ...
Cached Medicine Technology:Global CNS Drug Market: Strategic Assessments of Leading Suppliers 2Global CNS Drug Market: Strategic Assessments of Leading Suppliers 3Global CNS Drug Market: Strategic Assessments of Leading Suppliers 4Global CNS Drug Market: Strategic Assessments of Leading Suppliers 5Global CNS Drug Market: Strategic Assessments of Leading Suppliers 6Global CNS Drug Market: Strategic Assessments of Leading Suppliers 7The Market for Prescription Dermatological Drugs, 7th Edition 2The Market for Prescription Dermatological Drugs, 7th Edition 3The Market for Prescription Dermatological Drugs, 7th Edition 4The Market for Prescription Dermatological Drugs, 7th Edition 5The Market for Prescription Dermatological Drugs, 7th Edition 6The Market for Prescription Dermatological Drugs, 7th Edition 7The Market for Prescription Dermatological Drugs, 7th Edition 8The Market for Prescription Dermatological Drugs, 7th Edition 9The Market for Prescription Dermatological Drugs, 7th Edition 10The Market for Prescription Dermatological Drugs, 7th Edition 11The Market for Prescription Dermatological Drugs, 7th Edition 12The Market for Prescription Dermatological Drugs, 7th Edition 13The Market for Prescription Dermatological Drugs, 7th Edition 14The Market for Prescription Dermatological Drugs, 7th Edition 15
... assays are designed for ... 2000, a high-throughput, continuous ... IMMULITE 2000 offers testing ... a rapidly expanding menu ...
... The Detection Of Serum ... C-Peptide Measurement:, Evaluating ... , Assisting in the ... , Differentiating insulin dependent ...
Inquire...
The Pach IV is the premier product for cornea thickness measurement in conjunction with Glaucoma screening....
Medicine Products: