Navigation Links
Anti-cancer drug damages brain vessels
Date:2/11/2008

The cancer drug Avastin (bevacizumab) is used to treat advanced bowel cancer in combination with chemotherapy. This drug targets a protein called VEGF (vascular endothelial growth factor) that stimulates blood vessel growth. Avastin inhibits the growth of tumors by cutting off their blood supply, which deprives them of oxygen and other nutrients. In a small percentage of patients, however, Avastin can cause neurological side effects ranging from headaches and blurry vision to potentially fatal seizures and brain swelling.

The new study reveals that VEGF normally protects the specialized cells that create a seal between the brain and spinal column and thus prevent fluid from leaking into the brain. When VEGF was blocked in mice, these cells died and the animals developed brain swelling. The authors suspect that Avastins side effects in humans may be caused by a similar phenomenon. Why these symptoms occur in only a few patients is not yet known.


'/>"/>

Contact: Hema Bashyam
hbashyam@rockefeller.edu
212-327-7053
Journal of Experimental Medicine
Source:Eurekalert

Page: 1

Related medicine news :

1. Synthesis of natural molecule could lead to better anti-cancer drugs
2. Carbon monoxide counteracts one side-effect of an anti-cancer drug
3. Scientific evidence of the significant anti-cancer effect of milk thistle
4. Telomerase enzyme structure provides significant new target for anti-cancer therapies
5. A Chinese medicine compound has satisfactory anti-cancer effects on hepatocellular carcinoma
6. Aida Granted Additional Anti-Cancer Patent
7. Discovery of widespread tumor growth gene holds promise for effective anti-cancer treatment
8. Experimental anti-cancer drug made from corn lillies kills brain tumor stem cells
9. Novel MRI Technique Shows Secondhand Smoke Damages Lungs
10. Special MRI Shows Secondhand Smoke Damages Lungs
11. Secondhand smoke damages lungs, MRIs show
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/24/2017)... , ... February 24, 2017 , ... Only two months ... Luxury Travel Market (ILTM) show in Cannes (France), XO Private has initiated a second ... the 420-page book measures almost a metre across when open, weighs in at more ...
(Date:2/24/2017)... , ... February 24, 2017 , ... The Smart Machine ... from Oxford University predict that 47 percent of all jobs in the United States ... “smart” and “successful.” The day of the aggressive know-it-all who steamrolls over colleagues is ...
(Date:2/24/2017)... ... 2017 , ... The narrative in “ Signal 8: An Australian Paramedic’s Story ... his paramedic experiences. Schanssema describes the tragedies he saw, as well as his struggles ... , Schanssema, initially unsure of the career path he wanted to take, found fulfillment ...
(Date:2/24/2017)... ... February 24, 2017 , ... The International Association of Eating Disorders ... Beyond What You See” body image mannequin art competition. Selected from 15 submissions from ... the winner revealed at the 31st annual iaedp Symposium, March 22 – 26 in ...
(Date:2/24/2017)... ... February 24, 2017 , ... Congratulations to Head Over ... on February 12th. Ms. Esparza qualified into this prestigious status after winning ... in Las Vegas, Nevada. Frida is one of approximately 25 gymnasts in the ...
Breaking Medicine News(10 mins):
(Date:2/24/2017)... Februar 2017 ITL Limited, ( ASX: ... ist erfreut, für das zum 31. Dezember 2016 ... exzellente Ergebnisse vorlegen zu können. Eine vollständige Präsentation ... finden Sie hier . ... 2,12 Millionen USD (Dez. 2015: 1,04 Millionen USD; +104 %) ...
(Date:2/24/2017)... NEW YORK , Feb. 23, 2017 ... gives comprehensive insights on the various drugs ... The report covers all the drugs that ... Preclinical & Clinical). The pipeline focuses on ... small molecules, antibodies, stem cell therapies, recombinant ...
(Date:2/24/2017)... DUBLIN , Feb 24, 2017 Research ... Drugs Price Analysis and Strategies - 2016" report to their ... The ... provides drug pricing data and benchmarks in the global Urinary Incontinence ... What are the key drugs marketed for Urinary Incontinence ...
Breaking Medicine Technology: