Navigation Links
Anti-angiogenesis treatment improves hearing in some NF2 patients
Date:7/8/2009

ted and sporadic vestibular schwannomas. With this suggestion that angiogenesis was involved in these tumors, members of the research team offered treatment with bevacizumab (Avastin), which is FDA-approved for treatment of several forms of cancer, to NF2 patients in danger of complete hearing loss or other significant neurological damage.

Among the first ten NF2 patients to receive bevacizumab, treatment led to tumor shrinkage in nine, and six had 20 percent or greater reduction in tumor size. In those six patients, tumor shrinkage lasted from 11 to 16 months, longer than the four months typically seen in bevacizumab treatment of malignant brain tumors. Of seven patients who had started to lose their hearing before treatment, four experienced some hearing restoration two returning to work or school as a result improvement that has also lasted for up to 16 months. In one patient without significant tumor shrinkage or hearing improvement (he had lost all hearing prior to treatment), treatment alleviated headaches and nausea caused by brainstem compression, allowing him also to return to school.

"This study has opened a new approach to research and understanding of these tumors," says Emmanuelle di Tomaso, PhD, the study's senior author, formerly with the Steele Laboratory of Tumor Biology in the MGH Department of Radiation Oncology. "There had been a dogma that these tumors do not produce edema and are not angiogenic, concepts that now need to be reevaluated." She adds that the study also suggests that VEGF the angiogenesis factor blocked by bevacizumab may have a role in nerve physiology beyond the stimulation of blood vessel growth.

Plotkin notes, "Based on the results of this study, we have just opened the first formal clinical trial of a drug treatment for NF2. We are testing an exciting new, oral VEGF inhibitor that will be easier for patients to take bevacizumab is administered intravenously and may have fewer side eff
'/>"/>

Contact: Katie Marquedant
kmarquedant@partners.org
617-726-0337
Massachusetts General Hospital
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Drug Shows Promise in Nervous-System Tumor Treatment
2. Evidence-based information about complementary and alternative medicine treatments now available
3. Researchers identify potential patient safety risks among methadone maintenance treatment patients
4. Global Fund Increases AIDS, Tuberculosis and Malaria Prevention and Treatment Measures by 30-50% Over One Year
5. For Treatment of Dyslipidemia, Surveyed Physicians are Increasingly Switching Patients to a More Potent Statin Following the ENHANCE and SEAS Trials
6. National Survey: Americans Fear Paying for Cancer Treatment As Much As Dying of the Disease
7. Transdel Pharmaceuticals Completes Enrollment in Phase 3 Clinical Study for Novel Topical Pain Treatment
8. U.S. Food and Drug Administration and Xanodyne Agree on a Plan to Keep Propoxyphene-Containing Products Available as Treatment Options for the Management of Mild to Moderate Pain
9. Rice University teams award-winning device could benefit treatment of hand injuries
10. June 2009 Mayo Clinic Health Letter Highlights Probiotics, Carotid Artery and Breast Cancer Treatments
11. New strategies to improve treatment and ultimately prevent heart failure in children
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/18/2014)... Fraser University psychologists have made a brain-related discovery ... attention-deficit disorders. , This discovery opens up the ... or suppress a specific brain activity that the ... , The Journal of Neuroscience has ... John McDonald, an associate professor of psychology and ...
(Date:4/17/2014)... chronic inflammation in non-cancerous prostate tissue may have nearly ... those with no inflammation, according to results of a ... Kimmel Cancer Center. , The link between persistent inflammation ... high-grade prostate cancer those with a Gleason score ... the most aggressive and rapidly growing prostate cancers. , ...
(Date:4/17/2014)... of Experimental Biology and Medicine a ... and Paul Kenis in the Institute of Genomic ... of Illinois Urbana-Champaign describe their recent work on ... variety of cell functions including energy metabolism, signaling, ... in regulating normal cellular behavior, redox status has ...
(Date:4/17/2014)... biology team has created a new technology for ... could travel the body and selectively target cancer ... biological devices that monitor and modify human physiology ... However, no existing technology enabled bioengineers to build ... and respond in a customized fashion. , "The ...
(Date:4/17/2014)... one in five infants in the United States annually ... several months after birth. Research into probiotic use for ... April 1, 2014 issue of the British Medical ... "Probiotics and Infant Colic," concluding that the use of ... did not reduce crying or fussing in infants ...
Breaking Medicine News(10 mins):Health News:Scientists discover brain's anti-distraction system 2Health News:Chronic inflammation linked to 'high-grade' prostate cancer 2Health News:Chronic inflammation linked to 'high-grade' prostate cancer 3Health News:Live cell imaging reveals distinct alterations of subcellular glutathione potentials 2Health News:Building 'smart' cell-based therapies 2Health News:New study says probiotic use for infant colic is not effective in reducing symptoms 2
... , , ... personal injury attorney John David Hart has filed 29 lawsuits against ... Medtronic USA, Inc. and Medtronic Puerto Rico Operations Co., in connection ... fractures which could result in serious injury or death. , ...
... , , , ... today announced its first device, the ZOOM-100DC brain electrical activity ... U.S. Food and Drug Administration under section 510(k) of the ... electroencephalogram (EEG) device capable of recording and displaying EEG waveforms ...
... SCOTTSDALE, Ariz., Aug. 11 ... of interoperable workflow solutions that advance the quality and safety of ... e fe r ral , its portal-based ... a streamlined, patient-centric and highly accountable process for tracking referrals. ...
... , , HOUSTON, Aug. 11 ... on workers, compensation, has announced its recent network certification in the ... few to achieve this certification, which covers all 159 counties in ... to leading workers, compensation providers for third party administrators, managed care ...
... , , HERMOSA BEACH, Calif., ... Cancer (PADRES), a non-profit organization committed to improving the quality of life for ... Volleyball match as part of the 2009 AVP CROCS SLAM BUD ... . , , (Photo: http://www.newscom.com/cgi-bin/prnh/20090811/LA59829 ) , , ...
... National Non-profit Provides No ... ... know that cataracts are the leading cause of vision loss among adults 55 and ... cataract development. , , , , ,Moreover, a recent study out of the University of ...
Cached Medicine News:Health News:Texas Law Firm Files Multiple Suits Against Medtronic as Deadline Approaches 2Health News:BrainScope(TM) Receives FDA Clearance for Portable EEG Device 2Health News:BrainScope(TM) Receives FDA Clearance for Portable EEG Device 3Health News:Carefx's New Referral Management Solution Increases Hospital Referral Volume, Enhances Collaboration Among Specialists, PCPs and Patients 2Health News:Carefx's New Referral Management Solution Increases Hospital Referral Volume, Enhances Collaboration Among Specialists, PCPs and Patients 3Health News:Carefx's New Referral Management Solution Increases Hospital Referral Volume, Enhances Collaboration Among Specialists, PCPs and Patients 4Health News:Rockport Healthcare Group Continues to Grow Coverage Area With New Work Comp Network Certification in Georgia 2Health News:Kevin Nealon, Jordan Farmar, Walter Perez, Cristian de la Fuente and Other Celebrities Participated in Beach Volleyball Match for Children With Cancer 2Health News:Kevin Nealon, Jordan Farmar, Walter Perez, Cristian de la Fuente and Other Celebrities Participated in Beach Volleyball Match for Children With Cancer 3Health News:EyeCare America Works to Prevent Blindness Caused by Cataracts 2Health News:EyeCare America Works to Prevent Blindness Caused by Cataracts 3
(Date:1/14/2014)... , Jan. 14, 2014 Dynamic Healthcare Services, Inc. ... today that it acquired Progressive Home Medical Equipment, Inc. ("Progressive") ... 2014. The terms of the acquisition were not disclosed. ... ("DME") company providing a wide range of sleep, mobility, and ...
(Date:1/14/2014)... , Jan. 14, 2014 Animal Emergency Critical Care, a ... Leesburg, Virginia is the first in ... chamber. Dr. Susan M. Barnes , Medical ... Barnes and husband, Dr. Cole Taylor , are avid scuba ...
(Date:1/14/2014)... Jan. 14, 2014 NineSigma , Inc., the ... Innovation Leadership Summit , May 14-16, 2014 at ... Cleveland Ohio . This is ... committed to breakthrough achievements through open innovation. Participants will ...
Breaking Medicine Technology:Dynamic Healthcare Services Completes Progressive Home Medical Equipment of Clarion, PA Investment 2Dynamic Healthcare Services Completes Progressive Home Medical Equipment of Clarion, PA Investment 3Hyperbaric Veterinary Medicine (hvm) Announces Animal Emergency Critical Care Installs A Small Animal Hyperbaric Chamber 2Expect the Unexpected from Leading Global Innovators at NineSigma Leadership Summit, Sharing Winning Strategies to Advance Innovation 2Expect the Unexpected from Leading Global Innovators at NineSigma Leadership Summit, Sharing Winning Strategies to Advance Innovation 3Expect the Unexpected from Leading Global Innovators at NineSigma Leadership Summit, Sharing Winning Strategies to Advance Innovation 4
... Lead to More Effective Antibiotics Against ,Superbugs, ... College of Engineering may have discovered the path,toward ... that have developed resistance to common antibiotics. The,researchers ... occurring,in bacteria that opens to door to new ...
... Clinical ... WHIPPANY, N.J. and ATLANTA, Sept. 6 ... terms to acquire Zurich,Biostatistics, Inc. (ZBI). With the ... acquisition further strengthens,ISI,s Clinical Data Interchange Standards Consortium ...
Cached Medicine Technology:Boston University Biomedical Engineers Find Chink in Bacteria's Armor 2Boston University Biomedical Engineers Find Chink in Bacteria's Armor 3Image Solutions, Inc. Acquires Zurich Biostatistics, Inc. 2Image Solutions, Inc. Acquires Zurich Biostatistics, Inc. 3
... HIBICLENS bonds with ... a protective, germ-killing field. ... fast acting antimicrobial effect, ... irritation potential promotes compliance ...
... solution, allows the user to prep one ... in less than 2-minutes. It also utilizes ... surgical scrubbing and healthcare personnel handwashing. ACTIPREP ... provide a tacky surface for drapes to ...
... This multi-purpose topical gel contains 10% ... broad-spectrum germicidal action. As a pre-operative prep, ... pooling of prepping solutions under the patient, ... The Gel is also approved as a ...
... Scrub is a gentle and effective surgical ... dryness. Povidone Iodine is known to kill ... bacteria, fungi, viruses, protozoa and yeasts. It ... step in patient pre-operative prepping, as well ...
Medicine Products: