Navigation Links
Anti-aging gene identified as tumor suppressor in mice, research finds
Date:12/11/2012

ANN ARBOR, Mich. A new study sheds more light on how an anti-aging gene suppresses cancer growth, joint University of Michigan Health System and Harvard Medical School research shows.

Loss of the SIRT6 protein in mice increases the number, size and aggressiveness of tumors, according to the new research published in the scientific journal Cell. The study also suggests that the loss of SIRT6 promotes tumor growth in human colon and pancreatic cancers.

"It is critical to understand the spectrum of genes that suppress tumor development," says co-senior author David Lombard, M.D., Ph.D., assistant professor of pathology and assistant research professor at the U-M Institute of Gerontology at the U-M Medical School.

"Our research suggests SIRT6 may have a critical role in blocking cancer and controlling cellular metabolism. We hope to build on this work to better understand how this protein suppresses tumor development, and provide insight into potential future means of reprogramming cancer metabolism."

The research was done in conjunction with the Massachusetts General Hospital Cancer Center at Harvard Medical School. Raul Mostoslavsky, M.D., Ph.D., assistant professor of medicine at Harvard Medical School, was the co-senior author.

The new research highlights the role SIRT6 plays in dampening cancer growth by repressing aerobic glycolysis a major feature of cancer cells that involves the conversion of glucose to lactate. SIRT6 also inhibits activity of the key cancer gene Myc.

Many studies in cancer biology have focused on the importance of tumor suppressor proteins and how they may protect cells from progressing to cancer.

The new research follows up on previous studies that have tied SIRT6 to longevity in male mice. Other research has also shown that the protein may protect against diet-induced obesity.

"This work points to the conservation of biological mechanisms between lowe
'/>"/>

Contact: Beata Mostafavi
bmostafa@umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. US Drug Watchdog Now Urges Women Who Used Yaz or Yasmin Birth Control Pills and Had a Heart Attack or Stroke to Call The Johnson Law Group immediately-Get Identified Now
2. US Drug Watchdog Now Urges All DePuy Pinnacle And DePuy Hip Implant Recipients To Call Them For The Names Of The Best Law Firms Before Time Runs Out To Get Identified
3. Predictors of postpartum pelvic joint pain identified among working women
4. Pathway identified in human lymphoma points way to new blood cancer treatments
5. Novel mechanism through which normal stromal cells become cancer-promoting cells identified
6. Mechanism of breathing muscle paralysis in dreaming sleep identified
7. Biomarkers of behavior, therapeutic targets for adult B-acute lymphoblastic leukemia identified
8. Risk factors in hospital readmissions among general surgery patients identified in study
9. Novel therapeutic targets identified for small cell lung cancer
10. New genetic risk factor for inflammation identified in African-American women
11. Possible therapy for tamoxifen resistant breast cancer identified
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Anti-aging gene identified as tumor suppressor in mice, research finds
(Date:10/25/2014)... The proposed consolidation of all federally-filed ... December, when the U.S. Judicial Panel on Multidistrict Litigation ... Hearing Session Order issued by the Panel on October ... on December 4, 2014, in Charleston, South Carolina. The ... Xarelto Products Liability Litigation, No. 2592) , “Our Firm ...
(Date:10/25/2014)... (PRWEB) October 25, 2014 TASC ... medical and other benefits account management services, announces ... help employers save on taxes, reduce administrative workload, ... provide tax savings and the efficient handling of ... the Suite that best meets their goals and ...
(Date:10/25/2014)... 2014 The federal judge overseeing ... ) filed against Boston Scientific Corp. in the ... Southern District of West Virginia has denied a ... in a group of cases filed on behalf ... October 21st, U.S. District Judge Joseph R. Goodwin ...
(Date:10/25/2014)... Not getting the right amount of sleep might raise ... Those who sleep less or more than the ... more prone to developing the chronic condition, which causes ... concluded that duration and quality of sleep are key ... diseases. "Both short and long durations of sleep ...
(Date:10/25/2014)... -- October,s shorter, darker days can trigger a type ... an expert. People affected by seasonal affective ... motivation and even have trouble getting out of bed. ... Dr. Angelos Halaris, a professor in the department of ... School of Medicine. "Seasonal affective disorder should not ...
Breaking Medicine News(10 mins):Health News:Xarelto Lawsuit News: JPML to Hear Oral Arguments on Proposed Xarelto Multidistrict Litigation at December Hearing, Bernstein Liebhard LLP Reports 2Health News:Xarelto Lawsuit News: JPML to Hear Oral Arguments on Proposed Xarelto Multidistrict Litigation at December Hearing, Bernstein Liebhard LLP Reports 3Health News:TASC’s New Suites Offer Tax Savings and Protection 2Health News:Transvaginal Mesh Lawsuits Move Forward, As Federal Judge Denies Motion for Summary Judgment on Punitive Damages in Florida Cases, Bernstein Liebhard LLP Reports 2Health News:Transvaginal Mesh Lawsuits Move Forward, As Federal Judge Denies Motion for Summary Judgment on Punitive Damages in Florida Cases, Bernstein Liebhard LLP Reports 3Health News:Transvaginal Mesh Lawsuits Move Forward, As Federal Judge Denies Motion for Summary Judgment on Punitive Damages in Florida Cases, Bernstein Liebhard LLP Reports 4Health News:Sleep Duration Linked to Ulcerative Colitis Risk in Study 2Health News:Dark Days Here for Folks With Seasonal Depression 2
... Organization (NGO), sent over $3,000,000 of vitally needed medical supplies to ... ... -- In a continent often defined by man-made conflicts and natural ... success stories. Among the 53 countries in Africa there ...
... used as traditional remedies for hundreds of years. Among ... in treatment of hepatitis, inflammation, osteomyelitis and gynecological diseases ... barbata have growth inhibitory effects on a number ... of lung, breast and digestive system cancer, hepatoma, and ...
... Scantek Medical, Inc. (Pink Sheets: SKML)("Scantek") announced ... voluntary petition in the United States Bankruptcy Court pursuant ... States Code. Scantek also announced today that it ... Sensor product ("BreastCare") to a medical equipment supplier for ...
... genes initially appeared to be statistically significantly associated with ... individual studies are pooled, however, few DNA repair gene ... to a field synopsis published in the December 30 ... Cancer Institute. , Because DNA damage is associated ...
... didn,t halt women,s risk of developing disease , , TUESDAY, ... the supposed cancer-fighting powers of vitamins C and E, ... don,t prevent the disease in women. , And another ... new study found. , , "Simply taking antioxidant supplements ...
... Boston resident Barbara Gilchrest, MD, a member of ... and professor and chairman-emeritus of the Department of Dermatology ... recently named one of America,s Top Doctors by Castle ... recognized by consumers seeking high-quality medical care, is a ...
Cached Medicine News:Health News:Good News in Africa: Beyond the headlines 2Health News:Scantek Medical Files for Chapter 11 Voluntary Bankruptcy and Receives Orders for the Sale of BreastCare(TM) 2Health News:Few DNA repair genes maintain association with cancer in field synopsis 2Health News:Vitamins Fail to Prevent Cancer: Study 2Health News:Vitamins Fail to Prevent Cancer: Study 3Health News:BMC, Boston University School of Medicine dermatologist named one of America's Top Doctors 2
(Date:10/25/2014)... 2014 In conjunction with DURECT Corporation,s (Nasdaq: ... press release, you are invited to listen to the ... internet on Monday, November 3, 2014 at 4:30 pm ... live audio webcast of the presentation will be available ... clicking "Investor Relations."  If you are unable to participate ...
(Date:10/25/2014)... 24, 2014 Best Practices designed the ... with a forum for sharing insights about the ... a mechanism for creating and sharing solutions through ... findings from the Medical Affairs Consortium survey. ... for the first roundtable of the 2014-2015 Medical ...
(Date:10/22/2014)... 2014  Cephasonics, a technology-innovation leader with a game-changing ... (cQuest Ultrasound Box™-1), the first product in a new ... by Cephasonics for purchase by companies to rebrand with ... be showcasing the cQUB-1 for the first time at ... Chongqing, China from October 23 to ...
Breaking Medicine Technology:DURECT Corporation Invites You to Join its Third Quarter 2014 Earnings Conference Call 2Strong Participation in Best Practices' Medical Affairs Consortium Survey 2Cephasonics Launches the cQUB-1, First Product in New Family of cQUB White-Label Ultrasound Systems Targeted at Medical Applications 2Cephasonics Launches the cQUB-1, First Product in New Family of cQUB White-Label Ultrasound Systems Targeted at Medical Applications 3
... SUPERIOR, Colo., Jan. 10, 2011 Key Equipment ... finance companies and an affiliate of KeyCorp (NYSE: ... entered into an exclusive, long term, program agreement with ... America is the U.S. distributor of Hitachi Medical Corporation,s ...
... Jan. 8, 2011 - Bayer HealthCare Pharmaceuticals has become aware ... pads, swabs and swabsticks manufactured by the Triad Group and ... safety, Bayer wants to ensure that U.S. patients and physicians ... The recall of the Triad Group alcohol ...
Cached Medicine Technology:Key Equipment Finance Enters Long-Term Program Agreement With Hitachi Medical Systems America 2Key Equipment Finance Enters Long-Term Program Agreement With Hitachi Medical Systems America 3Important Information for Betaseron® (interferon beta 1-b) Consumers Regarding Triad Group's Alcohol Prep Products 2Important Information for Betaseron® (interferon beta 1-b) Consumers Regarding Triad Group's Alcohol Prep Products 3
... The Cryostage freezing stage is a refrigerated ... object holder, primarily for use with the 8000 ... other sledge microtomes. ,The refrigerated stage gives a ... the surface is ridged to provide good adhesion ...
... work, it is necessary to cool a specimen ... be fitted to most microtomes and will permit ... depending on conditions. The equipment consists of a ... stage is best suited for operation with a ...
... Freezing Stages fit easily onto most microtomes. ... need only the AC supply and a trickle ... starts immediately and can be maintained indefinitely. ... temperatures can be set for different kinds of ...
... MNL 4404 & 4405 series Freezing Stages ... devices have no moving parts and need only ... water for operation. Freezing starts immediately ... is adjustable so that optimum cutting temperatures can ...
Medicine Products: