Navigation Links
Anti-aging gene identified as tumor suppressor in mice, research finds
Date:12/11/2012

ANN ARBOR, Mich. A new study sheds more light on how an anti-aging gene suppresses cancer growth, joint University of Michigan Health System and Harvard Medical School research shows.

Loss of the SIRT6 protein in mice increases the number, size and aggressiveness of tumors, according to the new research published in the scientific journal Cell. The study also suggests that the loss of SIRT6 promotes tumor growth in human colon and pancreatic cancers.

"It is critical to understand the spectrum of genes that suppress tumor development," says co-senior author David Lombard, M.D., Ph.D., assistant professor of pathology and assistant research professor at the U-M Institute of Gerontology at the U-M Medical School.

"Our research suggests SIRT6 may have a critical role in blocking cancer and controlling cellular metabolism. We hope to build on this work to better understand how this protein suppresses tumor development, and provide insight into potential future means of reprogramming cancer metabolism."

The research was done in conjunction with the Massachusetts General Hospital Cancer Center at Harvard Medical School. Raul Mostoslavsky, M.D., Ph.D., assistant professor of medicine at Harvard Medical School, was the co-senior author.

The new research highlights the role SIRT6 plays in dampening cancer growth by repressing aerobic glycolysis a major feature of cancer cells that involves the conversion of glucose to lactate. SIRT6 also inhibits activity of the key cancer gene Myc.

Many studies in cancer biology have focused on the importance of tumor suppressor proteins and how they may protect cells from progressing to cancer.

The new research follows up on previous studies that have tied SIRT6 to longevity in male mice. Other research has also shown that the protein may protect against diet-induced obesity.

"This work points to the conservation of biological mechanisms between lower organisms and humans, and the importance of fundamental basic research," says Lombard, a researcher at the U-M Comprehensive Cancer Center. "This family of proteins was originally studied in yeast. It turns out to have key roles in promoting mammalian health."


'/>"/>

Contact: Beata Mostafavi
bmostafa@umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert  

Related medicine news :

1. US Drug Watchdog Now Urges Women Who Used Yaz or Yasmin Birth Control Pills and Had a Heart Attack or Stroke to Call The Johnson Law Group immediately-Get Identified Now
2. US Drug Watchdog Now Urges All DePuy Pinnacle And DePuy Hip Implant Recipients To Call Them For The Names Of The Best Law Firms Before Time Runs Out To Get Identified
3. Predictors of postpartum pelvic joint pain identified among working women
4. Pathway identified in human lymphoma points way to new blood cancer treatments
5. Novel mechanism through which normal stromal cells become cancer-promoting cells identified
6. Mechanism of breathing muscle paralysis in dreaming sleep identified
7. Biomarkers of behavior, therapeutic targets for adult B-acute lymphoblastic leukemia identified
8. Risk factors in hospital readmissions among general surgery patients identified in study
9. Novel therapeutic targets identified for small cell lung cancer
10. New genetic risk factor for inflammation identified in African-American women
11. Possible therapy for tamoxifen resistant breast cancer identified
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Anti-aging gene identified as tumor suppressor in mice, research finds
(Date:10/13/2017)... ... 2017 , ... While it’s often important to take certain medications during the ... Texas, has identified a solution. , She developed a prototype for MOTION LIGHT-UP PILL ... it eliminates the need to turn on a light when taking medication during the ...
(Date:10/13/2017)... ... October 13, 2017 , ... ... (SOP) alumni Hannah Randall, PharmD ‘17, and Jennifer Huggins, PharmD ’17, along ... updates for the primary prevention of cardiovascular diseases during the 15th Annual ...
(Date:10/13/2017)... ... October 13, 2017 , ... The Visiting Nurse Association (VNA) of Somerset Hills ... specialty vendors and unique items from across the nation, this holiday-themed event will raise ... offered by the VNA. The boutique will be open Saturday, November 4 (10:00 ...
(Date:10/13/2017)... , ... October 13, 2017 , ... ... be giving viewers the lowdown on sciatica in a new episode of "Success ... focuses on current events and innovation and investigates each subject in-depth with passion ...
(Date:10/12/2017)... ... October 12, 2017 , ... First Healthcare Compliance (FHC), ... will showcase a range of technology and learning solutions at the 68th Annual ... Expo to be held October 14–18, 2017 at the Mandalay Bay Resort in ...
Breaking Medicine News(10 mins):
(Date:10/12/2017)... 12, 2017   Divoti USA will engrave ... the standard of the latest FDA requirements, which stipulates new criteria ... Anyone in need of Medical ID jewelry such as Medical ID ... are engraved in terms of the new FDA requirements . ... Divoti offers this dark mark ...
(Date:10/11/2017)... 2017  Hill-Rom Holdings, Inc. ("Hill-Rom") (NYSE: HRC), today ... Las Piedras, Puerto Rico , where ... Following a comprehensive ... minor structural damage, temporary loss of power and minimal ... completed, manufacturing operations have resumed, and the company expects ...
(Date:10/4/2017)... , Oct. 4, 2017  South Korean-based healthcare ... CPR training aide "cprCUBE" on Kickstarter. The device will ... during cardiac arrests with better efficiency compared to the ... offers real-time feedback on efficacy of the compression for ... campaign has a goal to raise $5,000. ...
Breaking Medicine Technology: