Navigation Links
Anti-aging drug breakthrough
Date:3/8/2013

Drugs that combat ageing may be available within five years, following landmark work led by an Australian researcher.

The work, published in the March 8 issue of Science, finally proves that a single anti-ageing enzyme in the body can be targeted, with the potential to prevent age-related diseases and extend lifespans.

The paper shows all of the 117 drugs tested work on the single enzyme through a common mechanism. This means that a whole new class of anti-ageing drugs is now viable, which could ultimately prevent cancer, Alzheimer's disease and type 2 diabetes.

"Ultimately, these drugs would treat one disease, but unlike drugs of today, they would prevent 20 others," says the lead author of the paper, Professor David Sinclair, from UNSW Medicine, who is based at Harvard University. "In effect, they would slow ageing."

The target enzyme, SIRT1, is switched on naturally by calorie restriction and exercise, but it can also be enhanced through activators. The most common naturally-occurring activator is resveratrol, which is found in small quantities in red wine, but synthetic activators with much stronger activity are already being developed.

Although research surrounding resveratrol has been going for a decade, until now the basic science had been contested. Despite this, there have already been promising results in some trials with implications for cancer, cardiovascular disease and cardiac failure, type 2 diabetes, Alzheimer's and Parkinson's diseases, fatty liver disease, cataracts, osteoporosis, muscle wasting, sleep disorders and inflammatory diseases such as psoriasis, arthritis and colitis (inflammatory bowel disease).

"In the history of pharmaceuticals, there has never been a drug that tweaks an enzyme to make it run faster," says Professor Sinclair, a geneticist with the Department of Pharmacology at UNSW.

The technology was sold to pharmaceutical giant GlaxoSmithKline in 2008[i]. Fou
'/>"/>

Contact: Susi Hamilton
susi.hamilton@unsw.edu.au
61-422-934-024
University of New South Wales
Source:Eurekalert

0

GOOD

Page: 1 2

Related medicine news :

1. Skinfood Anti-Aging Moisturizers pack a double punch to fight dry, undernourished skin and fine lines with a new line of nourishing products from Gerda Spillmann
2. Perfect Choice Trading Inc. Announces MiLEOX, a New Line of Anti-aging Skin Care Products
3. New - Renaissance Age Serum, a Revival in Swiss Anti-Aging Skin Care; Improve Skin Texture for a More Youthful Appearance using Gerda Spillmann’s Newest Anti-Aging Serum
4. Mari's Skin Care is Now Offering a New Anti-aging Treatment
5. Living to 100 with Anti-Aging and Rejuvenation Stem Cells Therapy
6. The Center for Anti-Aging Will Now Be Offering Its Vitamins and Herbal Supplements on Amazon
7. EvoDerma Celebrates New Anti-Aging Device with Promotion
8. Hormone Replacement Clinic, Renew Health and Wellness Opens in Richmond, Virginia. New Center Specializes in Anti-Aging Therapies for both Women and Men.
9. Hormone Replacement Clinic, Renew Health and Wellness Opens in St. Louis, Missouri Area. New Center Specializes in Anti-Aging Therapies for both Women and Men.
10. Anti-aging gene identified as tumor suppressor in mice, research finds
11. Dallas Dermatologist Christine Brown, M.D. Now Offers Breakthrough Technology to Freeze Away Fat
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/18/2013)... 2013 Seven-year-old Riley Salz of Encino, ... He receives 40 hours a week of applied behavior ... the Center for Autism and Related Disorders (CARD). Riley ... and has experienced remarkable progress, including learning to speak, ... Riley’s personal journey through autism is now featured in ...
(Date:6/18/2013)... Center clinical researchers have launched an innovative clinical ... the ability of a patient,s own stem cells ... arterial disease (PAD). , Led by Vik ... Hospitals Case Medical Center,s Harrington Heart & Vascular ... Reserve University School of Medicine, the clinical trial ...
(Date:6/18/2013)... More than 1.1 million people in the ... to the Centers for Disease Control and Prevention (CDC). Of ... support of National HIV Testing Day on June 27, Allsup, ... (SSDI) representation, the CDC and other organizations are raising awareness ... reports about 50,000 new HIV infections each year. Along with ...
(Date:6/18/2013)... (PRWEB) June 18, 2013 myCNAjobs announces ... of free downloads, articles, and tips to the Caregiver ... to care for the 10,000+ retiring baby boomers each ... professional caregiver job resources has never been ... CNA job community, recently launched the first-ever free ...
(Date:6/18/2013)... A new $119 million industry is taking ... is redefining the way consumers get their seafood. ... culinary chefs on the Emerald Coast panhandle of Northwest ... and the promising industry of aquaculture. , The word ... strive to fully partake in the effort, especially when ...
Breaking Medicine News(10 mins):Health News:June's Release of CARD's "Mission Possible: Portraits of Hope" Features Southern California Child and His Remarkable Progress with Intensive Autism Therapy 2Health News:June's Release of CARD's "Mission Possible: Portraits of Hope" Features Southern California Child and His Remarkable Progress with Intensive Autism Therapy 3Health News:UH Case Medical Center launches novel clinical trial using stem cells to prevent amputation 2Health News:Allsup Observes National HIV Testing Day June 27 2Health News:Allsup Observes National HIV Testing Day June 27 3Health News:myCNAjobs Adds New Resources to Growing Caregiver Career Center 2Health News:New $119 Million Industry Swimming Up the East Coast 2
... -- Men with low testosterone levels may be at increased ... a finding that challenges the current belief that testosterone is ... The study included 930 men with coronary artery disease ... of the study, low testosterone levels were noted in about ...
... ARBOR, Mich. Millions worldwide die each year because they ... States say they,d be willing to donate theirs after death ... Circulation, experts at the University of Michigan Cardiovascular ... they are removed for burial or cremation, for sterilization and ...
... Reinberg HealthDay Reporter , TUESDAY, Oct. 19 (HealthDay ... mothers and their infants from taking supplemental fish oil in ... finds no such benefit. In this large randomized, ... found no benefit from DHA in reducing levels of postpartum ...
... 19 (HealthDay News) -- Kidney-failure patients can continue taking a ... study showed they can increase the risk of stroke, U.S. ... and Drug Administration advisers voted 15-1, with one abstention, to ... disease who aren,t yet in need of dialysis, the ...
... Medicine investigated the role between adiponectin and leptin in ... issue of Hepatology , suggest that the protein ... of leptin, namely in hepatocellular carcinoma (HCC), and could ... Obesity is on the rise and is associated with ...
... Neuralstem, Inc. (NYSE Amex: CUR) updated the progress of ... company,s spinal cord stem cells in the treatment of ... Emory University in Atlanta, Georgia. The company announced that, ... non-ambulatory patients, the trial,s Safety Monitoring Board has unanimously ...
Cached Medicine News:Health News:Low Testosterone May Raise Risk of Early Death: Study 2Health News:Recycling pacemakers may alleviate burden of heart disease across the globe 2Health News:Recycling pacemakers may alleviate burden of heart disease across the globe 3Health News:Fish Oil Pills Don't Affect Postpartum Depression: Study 2Health News:Fish Oil Pills Don't Affect Postpartum Depression: Study 3Health News:Fish Oil Pills Don't Affect Postpartum Depression: Study 4Health News:FDA Advisers Back Anemia Drugs for Kidney Patients 2Health News:FDA Advisers Back Anemia Drugs for Kidney Patients 3Health News:FDA Advisers Back Anemia Drugs for Kidney Patients 4Health News:Adiponectin shows potential in blocking obesity-related carcinogenesis 2Health News:Neuralstem updates ALS clinical trial progress 2
(Date:6/17/2013)... June 17, 2013 Vanda Pharmaceuticals Inc. ... data today at ENDO 2013, the Endocrine Society,s ... can entrain (synchronize) both melatonin and cortisol rhythms. ... the master body clock and address the circadian ... The SET (Safety and Efficacy of Tasimelteon) and ...
(Date:6/17/2013)... Quebec , June 17, 2013 Valeant Pharmaceuticals ... announced today that it has filed a preliminary prospectus supplement ... has today made a similar filing with securities regulatory authorities ... in connection with a public offering of its common ... "Offering"). The Company will also grant to the ...
(Date:6/17/2013)... NEW YORK , June 17, 2013 The ... and CEO, The Partnership at Drugfree.org :   ... to CNN that it was halting the sale of prescription ... of product we recognize that from time to time there ... are not our customer. As a result of this misinterpretation ...
Breaking Medicine Technology:Vanda Presents Data From Phase III Studies that Demonstrate Tasimelteon Restores Daily Cortisol Rhythm In Blind Patients With Non-24-Hour Disorder 2Vanda Presents Data From Phase III Studies that Demonstrate Tasimelteon Restores Daily Cortisol Rhythm In Blind Patients With Non-24-Hour Disorder 3Vanda Presents Data From Phase III Studies that Demonstrate Tasimelteon Restores Daily Cortisol Rhythm In Blind Patients With Non-24-Hour Disorder 4Valeant Pharmaceuticals Announces Public Offering Of Common Shares 2Valeant Pharmaceuticals Announces Public Offering Of Common Shares 3Valeant Pharmaceuticals Announces Public Offering Of Common Shares 4A Win for Families: Urban Outfitters Halts Prescription Drug Paraphernalia Product Sales 2
... UL, a world leader in advancing ... testing GmbH (MDT) and md registration support Ltd. (MDRS).  These ... UL,s Life and Health business unit.   MDT ... the medical services industry.  MDT specializes in clinical and non-clinical ...
... 2011 Apnex Medical, Inc., received investigational device exemption ... (FDA) to begin a clinical study to evaluate the ... System to treat obstructive sleep apnea (OSA). Data from ... Approval (PMA) application for the HGNS System to the ...
Cached Medicine Technology:UL Expands Presence in Medical Device Market With Acquisition of MDT 2UL Expands Presence in Medical Device Market With Acquisition of MDT 3Apnex Medical, Inc. Receives FDA Approval for Pivotal Clinical Study for Obstructive Sleep Apnea 2Apnex Medical, Inc. Receives FDA Approval for Pivotal Clinical Study for Obstructive Sleep Apnea 3
Directional `E' and `C' test....
9" X 14" translucent plastic may be used with illuminated test cabinet or as a wall chart 20/200 to 20/15....
... The PowerLab/16SP is a high-performance recording unit ... science research applications that require up to ... and isolated tissue studies. The unit is ... to 200 000 samples per second continuously ...
Three Figure Worth Type Test, this test is used for determining diplopia, suppression or fusion in children. Sturdy chrome flashlight comes with red/green glasses. Requires 3 D batteries which are no...
Medicine Products: