Navigation Links
Anti-Muellerian hormone predicts IVF success
Date:2/11/2013

Chevy Chase, MD Women with a high concentration of anti-Mllerian hormone stand a better chance of giving birth after in vitro fertilization, according to a recent study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM).

Anti-Mllerian hormone (AMH) is produced by the ovaries. The study found women with high AMH levels were 2.5 times more likely to have a successful IVF cycle than women of a similar age with low levels of the hormone. AMH levels were a predictor of pregnancy and live birth, even when the mother's age and egg production were taken into account.

Although a growing body of research has pinpointed AMH levels as an indicator of the number of eggs remaining in a woman's ovaries, this study is the first to demonstrate AMH levels are directly connected to birth and pregnancy rates, regardless of the number of eggs retrieved.

"For women who are struggling to get pregnant, a high AMH level should be very reassuring," said Thomas Brodin, MD, of Uppsala University in Sweden and lead author of the study. "High levels of this hormone mean there is a greater chance they have plenty of healthy eggs remaining to support a pregnancy."

Researchers concluded high AMH levels are associated with successful IVF treatment because the hormone levels reveal important information about the quality as well as the quantity of eggs left in a woman's ovaries. Women who have high AMH levels are likely to have a high proportion of eggs capable of developing into healthy embryos, Brodin said.

The prospective cohort study tracked 892 women who underwent IVF treatment at the Carl von Linn Clinic in Uppsala between 2008 and 2011. The participants underwent a total of 1,230 IVF cycles. AMH levels in the participants' blood were measured prior to treatment.

The study found that women were more likely to have a successful treatment outcome as their AMH levels increased. Women who had AMH levels above 2.94 ng/ml had the highest birth rates. The effect leveled out when AMH levels surpassed 5 ng/ml.

Although researchers did not find a cut-off point below which women could not get pregnant, IVF success rates dropped substantially as AMH levels declined. Among the study participants who had AMH levels below 0.2 ng/ml, 53 IVF cycles resulted in only 18 embryo transfers and the birth of three children.

The study found reason for optimism among women who have polycystic ovary syndrome, a condition normally associated with ovulation problems. Women who have this condition tend to have high AMH levels.

"Our data suggests women who have polycystic ovaries are likely to be good candidates for IVF," Brodin said. "Along with high AMH levels, this group tends to have a significant supply of eggs remaining in the ovaries."


'/>"/>

Contact: Jenni Glenn Gingery
jgingery@endo-society.org
301-941-0240
The Endocrine Society
Source:Eurekalert

Related medicine news :

1. Study finds hormones can change the breasts genetic material
2. Test for hormone-disrupting chemicals gets global seal of approval
3. Love Hormone May Aid Womens Recovery After Childbirth
4. New hormone therapy shows promise for menopausal symptoms in animal model
5. Hormone Replacement Clinic, Renew Health and Wellness Opens in Richmond, Virginia. New Center Specializes in Anti-Aging Therapies for both Women and Men.
6. Hormone Replacement Clinic, Renew Health and Wellness Opens in St. Louis, Missouri Area. New Center Specializes in Anti-Aging Therapies for both Women and Men.
7. Too Little Sleep Spurs Appetite-Boosting Hormones: Study
8. High hormone levels put young black males at risk for cardiovascular disease
9. Could Hormone Spray Help Men Stay, Not Stray?
10. Feel-good hormone helps to jog the memory
11. Pregnancy Hormone Shows Promise as Heart Failure Drug
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... June 25, 2016 , ... As a lifelong Southern Californian, Dr. Omkar Marathe ... from the David Geffen School of Medicine at UCLA. He trained in Internal Medicine ... his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he had the ...
(Date:6/24/2016)... CA (PRWEB) , ... June 24, 2016 , ... A ... procedures that most people are unfamiliar with. The article goes on to state that ... but also many of these less common operations such as calf and cheek reduction. ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... Scientific Sessions in Dallas that it will receive two significant new grants to ... came as PHA marked its 25th anniversary by recognizing patients, medical professionals and ...
(Date:6/24/2016)... ... ... makers of Topricin and MyPainAway Pain Relief Products, join The ‘Business for a Fair Minimum ... by 2020 and then adjusting it yearly to increase at the same rate as the ... wage floor does not erode again, and make future increases more predictable. , The company ...
(Date:6/24/2016)... ... June 24, 2016 , ... Puradigm® & Innovative Solutions today ... cultivation and processing operations at its production facility, and opened its first two ... the manufacturer of a complete system of proactive air and surface purification solutions ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... 2016 Jazz Pharmaceuticals plc (Nasdaq: ... Hart-Scott-Rodino Antitrust Improvements Act of 1976, as amended ("HSR"), ... Inc. ("Celator"; Nasdaq: CPXX ) expired effective ... As previously announced on May 31, 2016, ... agreement under which Jazz Pharmaceuticals has commenced a tender ...
(Date:6/24/2016)... June 24, 2016  Consumers have taken a ... have placed more emphasis on patient outcomes. ... programs in the pharmaceutical industry have evolved beyond ... pharmaceutical companies are focusing on becoming more patient-oriented ... products and services that improve health. ...
(Date:6/24/2016)... , June 24, 2016   Bay Area ... Network,s Dean Center for Tick Borne Illness ... and Rehabilitation, MIT Hacking Medicine, University of California, ... today announced the five finalists of Lyme ... disease.  More than 100 scientists, clinicians, researchers, entrepreneurs, ...
Breaking Medicine Technology: