Navigation Links
Anti-Inflammatory Helps Treat Bacterial Meningitis: Study
Date:9/29/2010

By Steven Reinberg
HealthDay Reporter

WEDNESDAY, Sept. 29 (HealthDay News) -- Using the anti-inflammatory drug dexamethasone along with antibiotics increases the chance of surviving a bout with bacterial meningitis, Dutch researchers report.

"Dexamethasone therapy reduces mortality from bacterial meningitis by one-third," said lead researcher Dr. Diederik van de Beek, a clinical neurologist from the Academic Medical Center at the University of Amsterdam.

"That's a huge effect," he added. "Normally, the death rate of bacterial meningitis is 30 percent; if you use dexamethasone, it decreases to 20 percent."

The report is published in the Sept. 29 online edition and the Oct. 26 print issue of Neurology.

For the study, van de Beek's team collected data on 357 people 16 and older who had bacterial meningitis between 2006 and 2009. Of these patients, 84 percent were given a dose of dexamethasone, a corticosteroid, before antibiotic treatment was started.

The researchers compared the outcomes of these patients with 352 patients treated for bacterial meningitis between 1998 and 2002, before dexamethasone was routinely given for the infection. Among these patients, only 3 percent had been given dexamethasone, the researchers noted.

Deaths among those given dexamethasone in the 2006-2009 study group were 10 percent lower than for those in the early study group. In addition, hearing loss was almost 10 percent lower for people in the 2006-2009 study group compared with the earlier group, the investigators found.

"If you extrapolate these findings to the U.S., if you treat all patients with bacterial meningitis with dexamethasone, that would save one life every day," van de Beek said.

Guidelines in the United States recommend the use of dexamethasone for suspected cases of bacterial meningitis, he added.

Jeffrey Cirillo, an associate professor of microbial and molecular pathogenesis at Texas A&M Health Science Center College of Medicine, said that the study's results confirmed previous findings in clinical trials and laboratory models that dexamethasone treatment in combination with antibiotics can reduce mortality in patients.

"These results strongly support the use of dexamethasone in cases of pneumococcal meningitis and offer promise to improve the chances of survival from meningitis, a frequently deadly illness," Cirillo added.

Since 2000, a vaccine against bacterial meningitis has been available. A study last year confirmed that the vaccine has significantly cut the number of cases of the disease.

Overall, the number of cases of the disease dropped 30 percent in that time, but the effect on the very youngest and oldest was even more pronounced: Incidence decreased by 64 percent in those younger than 2 and by 54 percent in those older than 65, according to the report, published in the Jan. 15, 2009 issue of the New England Journal of Medicine.

The vaccine, known as Prevnar and made by Wyeth Pharmaceuticals, is part of the standard vaccination recommendation for children in the United States ages 2 to 23 months, as well as for children 24 to 59 months old who are at high risk for pneumococcal disease.

Meningitis causes inflammation to the membranes in the brain and spinal cord. Bacterial meningitis, unlike viral meningitis, can be deadly and can also cause hearing loss, brain damage and learning disabilities. The most common and severe form of bacterial meningitis is pneumococcal meningitis. About 30 percent of people with bacterial meningitis die from it, according to background information provided in a news release from the American Academy of Neurology.

More information

For more information on bacterial meningitis, visit the U.S. Centers for Disease Control and Prevention.

SOURCES: Diederik van de Beek, M.D., Ph.D., clinical neurologist, Academic Medical Center, University of Amsterdam, the Netherlands; Jeffrey Cirillo, Ph.D., associate professor, microbial and molecular pathogenesis, Texas A&M Health Science Center College of Medicine, College Station, Texas; Sept. 29, 2010, Neurology, online


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Prozac and Celexa exhibit anti-inflammatory effects
2. Physician's Pain Relief Cream Includes Patented Anti-inflammatory in New Formula
3. Two New Phytochemicals with Anti-Inflammatory Activity Found in Noni Fruit
4. New research reinforces anti-inflammatory properties of tart cherries
5. Grant for rotten eggs anti-inflammatory research
6. UNT Health Science Centers Roby Helps Identify Bodies of Chiles Patio 29
7. MarquisNet Co-Location Agreement with MessageBroadcast Helps Message Delivery Provider Expand World-Class Network
8. Launch of On Time Air Filters: Home Air Filter Delivery Service Helps Homeowners Replace All-Important Home HVAC Filters On Time
9. New intervention helps Latino parents of asthmatic children quit smoking
10. Hair Loss: Must See Photos - Scalpure Hair Mask Helps Hair Loss
11. Exercise helps protect brain of multiple sclerosis patients
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Anti-Inflammatory Helps Treat Bacterial Meningitis: Study
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... ... health policy issues and applications at AcademyHealth’s Annual Research Meeting June 26-28, 2016, ... work on several important health care topics including advance care planning, healthcare costs ...
(Date:6/25/2016)... ... ... "With 30 hand-drawn hand gesture animations, FCPX users can easily customize each ... Film Studios. , ProHand Cartoon’s package transforms over 1,300 hand-drawn pictures into hand ... select a ProHand generator and drag it above media or text in the Final ...
(Date:6/25/2016)... ... June 25, 2016 , ... ... recover from injury. Recently, he has implemented orthobiologic procedures as a method for ... is one of the first doctors to perform the treatment. Orthobiologics are substances ...
(Date:6/24/2016)... CA (PRWEB) , ... June 24, 2016 , ... A ... procedures that most people are unfamiliar with. The article goes on to state that ... but also many of these less common operations such as calf and cheek reduction. ...
(Date:6/24/2016)... ... June 24, 2016 , ... Marcy was in a crisis. Her son James, eight, was out ... family verbally and physically. , “When something upset him, he couldn’t control his emotions,” remembers ... would throw rocks at my other children and say he was going to kill them. ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... June 24, 2016 Dehaier Medical Systems Ltd. ... which develops, markets and sells medical devices and wearable ... signed a strategic cooperation agreement with Hongyuan Supply Chain ... Chain") on June 20, 2016, to develop Dehaier,s new ... cooperation agreement, Dehaier will leverage Hongyuan Supply Chain,s sales ...
(Date:6/24/2016)... 2016 Research and Markets has announced ... Diagnostic Tests" report to their offering. ... The World Market for Companion Diagnostics covers ... Market analysis in the report includes the following: ... Diagnostic Kits) by Region (N. America, EU, ROW), 2015-2020 ...
(Date:6/24/2016)... , June 24, 2016   Pulmatrix, Inc ., ... developing innovative inhaled drugs, announced today that it was ... Investments reconstituted its comprehensive set of U.S. and ... "This is an important milestone for Pulmatrix," said Chief ... shareholder awareness of our progress in developing drugs for ...
Breaking Medicine Technology: