Navigation Links
Anti-Inflammatory Helps Treat Bacterial Meningitis: Study
Date:9/29/2010

By Steven Reinberg
HealthDay Reporter

WEDNESDAY, Sept. 29 (HealthDay News) -- Using the anti-inflammatory drug dexamethasone along with antibiotics increases the chance of surviving a bout with bacterial meningitis, Dutch researchers report.

"Dexamethasone therapy reduces mortality from bacterial meningitis by one-third," said lead researcher Dr. Diederik van de Beek, a clinical neurologist from the Academic Medical Center at the University of Amsterdam.

"That's a huge effect," he added. "Normally, the death rate of bacterial meningitis is 30 percent; if you use dexamethasone, it decreases to 20 percent."

The report is published in the Sept. 29 online edition and the Oct. 26 print issue of Neurology.

For the study, van de Beek's team collected data on 357 people 16 and older who had bacterial meningitis between 2006 and 2009. Of these patients, 84 percent were given a dose of dexamethasone, a corticosteroid, before antibiotic treatment was started.

The researchers compared the outcomes of these patients with 352 patients treated for bacterial meningitis between 1998 and 2002, before dexamethasone was routinely given for the infection. Among these patients, only 3 percent had been given dexamethasone, the researchers noted.

Deaths among those given dexamethasone in the 2006-2009 study group were 10 percent lower than for those in the early study group. In addition, hearing loss was almost 10 percent lower for people in the 2006-2009 study group compared with the earlier group, the investigators found.

"If you extrapolate these findings to the U.S., if you treat all patients with bacterial meningitis with dexamethasone, that would save one life every day," van de Beek said.

Guidelines in the United States recommend the use of dexamethasone for suspected cases of bacterial meningitis, he added.

Jeffrey Cirillo, an associate professor of microbial and molecular pathogenesis at Texas A&M Health Science Center College of Medicine, said that the study's results confirmed previous findings in clinical trials and laboratory models that dexamethasone treatment in combination with antibiotics can reduce mortality in patients.

"These results strongly support the use of dexamethasone in cases of pneumococcal meningitis and offer promise to improve the chances of survival from meningitis, a frequently deadly illness," Cirillo added.

Since 2000, a vaccine against bacterial meningitis has been available. A study last year confirmed that the vaccine has significantly cut the number of cases of the disease.

Overall, the number of cases of the disease dropped 30 percent in that time, but the effect on the very youngest and oldest was even more pronounced: Incidence decreased by 64 percent in those younger than 2 and by 54 percent in those older than 65, according to the report, published in the Jan. 15, 2009 issue of the New England Journal of Medicine.

The vaccine, known as Prevnar and made by Wyeth Pharmaceuticals, is part of the standard vaccination recommendation for children in the United States ages 2 to 23 months, as well as for children 24 to 59 months old who are at high risk for pneumococcal disease.

Meningitis causes inflammation to the membranes in the brain and spinal cord. Bacterial meningitis, unlike viral meningitis, can be deadly and can also cause hearing loss, brain damage and learning disabilities. The most common and severe form of bacterial meningitis is pneumococcal meningitis. About 30 percent of people with bacterial meningitis die from it, according to background information provided in a news release from the American Academy of Neurology.

More information

For more information on bacterial meningitis, visit the U.S. Centers for Disease Control and Prevention.

SOURCES: Diederik van de Beek, M.D., Ph.D., clinical neurologist, Academic Medical Center, University of Amsterdam, the Netherlands; Jeffrey Cirillo, Ph.D., associate professor, microbial and molecular pathogenesis, Texas A&M Health Science Center College of Medicine, College Station, Texas; Sept. 29, 2010, Neurology, online


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Prozac and Celexa exhibit anti-inflammatory effects
2. Physician's Pain Relief Cream Includes Patented Anti-inflammatory in New Formula
3. Two New Phytochemicals with Anti-Inflammatory Activity Found in Noni Fruit
4. New research reinforces anti-inflammatory properties of tart cherries
5. Grant for rotten eggs anti-inflammatory research
6. UNT Health Science Centers Roby Helps Identify Bodies of Chiles Patio 29
7. MarquisNet Co-Location Agreement with MessageBroadcast Helps Message Delivery Provider Expand World-Class Network
8. Launch of On Time Air Filters: Home Air Filter Delivery Service Helps Homeowners Replace All-Important Home HVAC Filters On Time
9. New intervention helps Latino parents of asthmatic children quit smoking
10. Hair Loss: Must See Photos - Scalpure Hair Mask Helps Hair Loss
11. Exercise helps protect brain of multiple sclerosis patients
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Anti-Inflammatory Helps Treat Bacterial Meningitis: Study
(Date:4/28/2017)... ... April 28, 2017 , ... It's not always common knowledge whether ... illnesses that are unclear as to whether or not they are contagious, and most ... of these illnesses. So, FindaTopDoc took a look into the matter. , They ...
(Date:4/28/2017)... ... April 28, 2017 , ... Getting enough sleep affects much more than energy – it ... 19 hours without sleep can compromise motor reaction time, which can increase the risk of ... is sharing the following tips from the NSF to help you sleep better and feel ...
(Date:4/28/2017)... VA (PRWEB) , ... April 28, 2017 , ... The ... volunteer board members and officers for 2017-2018. The annual board election process has been ... on a volunteer basis. , Thomas C. Dickerson, Ed.D., FACHE, succeeds Jim Hamilton, MHA, ...
(Date:4/28/2017)... National Harbor, Md. (PRWEB) , ... April 28, ... ... Urgent Care Association of America (UCAOA) and College of Urgent Care Medicine will ... Momentum 2017 workshops, sessions and speakers will help those in the industry adapt ...
(Date:4/28/2017)... ... April 28, 2017 , ... Yisrayl Hawkins, Pastor and Overseer at The House of ... the Creator responds to and which He does not. Yisrayl says with so many ... is the true name, but he says with a little Scripture, backed with a lot ...
Breaking Medicine News(10 mins):
(Date:4/19/2017)... N.J. , April 19, 2017  Novartis ... by the National Heart, Lung, and Blood Institute ... demonstrating that 58% of patients with treatment-naïve severe ... months when treated with eltrombopag at the initiation ... . The study evaluated three sequential treatment groups, ...
(Date:4/18/2017)... 2017 Cogentix Medical, Inc. (NASDAQ: CGNT), a ... Uro/Gyn and Gynecology markets with innovative and proprietary products, ... March 31, 2017 after the market close on Tuesday, ... host a conference call and webcast to discuss its ... 2017 at 4:30 p.m. Eastern Time (3:30 p.m. Central ...
(Date:4/18/2017)... 2017  Astute Medical, Inc., developer of biomarkers for ... presented at the 2017 National Kidney Foundation (NKF) ... through April 22. Physicians will present data on two ... risk for acute kidney injury (AKI) during the management ... Elevated levels of TIMP-2 and IGFBP-7 have ...
Breaking Medicine Technology: