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Anti-Inflammatory Drug Improves Glycemia, Lowers Inflammation in Obese, Young Adults
Date:1/27/2008

Salsalate May Help Reduce Risk for Diabetes, Heart Disease

ALEXANDRIA, Va., Jan. 28 /PRNewswire-USNewswire/ -- An anti-inflammatory drug similar to aspirin may provide an inexpensive means of treating and/or reducing the risk for diabetes in obese young adults by reducing glycemia and lowering inflammation, a study being published in the February issue of Diabetes Care finds.

While researchers have long been aware that high doses of aspirin could reduce blood glucose levels, they have neither understood the mechanisms behind this effect nor been willing to tolerate the risk for stomach bleeding associated with this treatment. However, recent breakthroughs in our understanding of why weight gain is unhealthy point an incriminating finger at inflammation, and suggest that anti-inflammatory treatment strategies might have benefits.

Salsalate -- a nonsteroidal, anti-inflammatory medication similar to aspirin that does not cause bleeding -- has been used for decades to reduce the pain of rheumatoid arthritis. This double-masked, placebo-controlled study found that salsalate substantially reduced glycemia as well as inflammation in obese, young adults, thereby likely reducing the risk of developing type 2 diabetes and heart disease.

"People who are overweight or obese are at high risk for developing type 2 diabetes," said lead researcher Dr. Allison B. Goldfine, Assistant Professor at Harvard Medical School and Research Investigator at the Joslin Diabetes Center. "We know they can reduce that risk by losing weight and increasing physical activity. But many people aren't good at maintaining those types of lifestyle changes over the long-term. Those people can be helped through pharmaceutical interventions. Our study was the first to look at the metabolic changes that occur when you give salsalate to obese people who have not yet developed diabetes. And we're really encouraged by what we found."

Specifically, the study fou
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SOURCE American Diabetes Association
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