Navigation Links
Anti-Inflammatory Drug Improves Glycemia, Lowers Inflammation in Obese, Young Adults
Date:1/27/2008

Salsalate May Help Reduce Risk for Diabetes, Heart Disease

ALEXANDRIA, Va., Jan. 28 /PRNewswire-USNewswire/ -- An anti-inflammatory drug similar to aspirin may provide an inexpensive means of treating and/or reducing the risk for diabetes in obese young adults by reducing glycemia and lowering inflammation, a study being published in the February issue of Diabetes Care finds.

While researchers have long been aware that high doses of aspirin could reduce blood glucose levels, they have neither understood the mechanisms behind this effect nor been willing to tolerate the risk for stomach bleeding associated with this treatment. However, recent breakthroughs in our understanding of why weight gain is unhealthy point an incriminating finger at inflammation, and suggest that anti-inflammatory treatment strategies might have benefits.

Salsalate -- a nonsteroidal, anti-inflammatory medication similar to aspirin that does not cause bleeding -- has been used for decades to reduce the pain of rheumatoid arthritis. This double-masked, placebo-controlled study found that salsalate substantially reduced glycemia as well as inflammation in obese, young adults, thereby likely reducing the risk of developing type 2 diabetes and heart disease.

"People who are overweight or obese are at high risk for developing type 2 diabetes," said lead researcher Dr. Allison B. Goldfine, Assistant Professor at Harvard Medical School and Research Investigator at the Joslin Diabetes Center. "We know they can reduce that risk by losing weight and increasing physical activity. But many people aren't good at maintaining those types of lifestyle changes over the long-term. Those people can be helped through pharmaceutical interventions. Our study was the first to look at the metabolic changes that occur when you give salsalate to obese people who have not yet developed diabetes. And we're really encouraged by what we found."

Specifically, the study found that people who took 4 grams per day of salsalate reduced fasting glucose levels by 13 percent and C-reactive protein concentrations (a marker of inflammation) by 34 percent. Previous studies have implicated inflammation in the development of type 2 diabetes and heart disease.

The encouraging results from this small population study have prompted the National Institutes of Health to fund a larger, follow-up study that will look at safety and efficacy of targeting inflammation using salsalate in the treatment of type 2 diabetes. The study is currently ongoing at multiple sites across the country.

To reach Dr. Allison B. Goldfine, phone: 617-732-2643 or email: Allison.Goldfine@joslin.harvard.edu.

For more information about the study, please visit http://www.tinsalt2d.org.

Diabetes Care, published by the American Diabetes Association, is the leading peer-reviewed journal of clinical research into the nation's fifth leading cause of death by disease. Diabetes also is a leading cause of heart disease and stroke, as well as the leading cause of adult blindness, kidney failure, and non-traumatic amputations. For more information about diabetes, visit the American Diabetes Association Web site http://www.diabetes.org or call 1-800-DIABETES (1-800-342-2383).


'/>"/>
SOURCE American Diabetes Association
Copyright©2008 PR Newswire.
All rights reserved

Related medicine news :

1. Study Demonstrates Marteks Algal DHA Oil Improves Blood Triglyceride Lipid Levels
2. Exercise and yoga improves quality of life in women with early-stage breast cancer
3. Enhanced PrecyseCode 2X(TM) Further Accelerates Remote Coding and Improves Cash Flow for Hospitals
4. Weight-based dosing of ribavirin improves outcomes for patients with hepatitis C
5. Kerry Extends, Improves Small Business Innovation Program
6. Thalidomide Improves Outcomes for Older Myeloma Patients
7. Grape Consumption Improves Antioxidant Capacity in Humans
8. JCSM: CPAP therapy improves symptoms of depression in OSA patients
9. Early intervention dramatically improves outcomes for new dialysis patients
10. New technique improves purity of medicines
11. Novel medication improves ovarian cancer treatment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... Brooklyn, NY (PRWEB) , ... June 27, 2016 ... ... is using cutting edge technology to revolutionize the emergency ambulance transport experience for ... Many are aware of how Uber has disrupted the taxi industry through the ...
(Date:6/26/2016)... ... June 26, 2016 , ... Pixel Film Studios Released ProSlice Levels, a Media ... give their videos a whole new perspective by using the title layers in ... Studios. , ProSlice Levels contains over 30 Different presets to choose from. ...
(Date:6/25/2016)... ... June 25, 2016 , ... Experts from the American Institutes ... Research Meeting June 26-28, 2016, at the Hynes Convention Center in Boston. , ... advance care planning, healthcare costs and patient and family engagement. , AIR researchers ...
(Date:6/25/2016)... ... June 25, 2016 , ... First Choice Emergency ... named Dr. Sesan Ogunleye, as the Medical Director of its new Mesquite-Samuell Farm facility. ... Director of our new Mesquite location,” said Dr. James M. Muzzarelli, Executive Medical Director ...
(Date:6/25/2016)... ... June 25, 2016 , ... Conventional wisdom preaches the ... In terms of the latter, setting the bar too high can result in disappointment, ... just slow progress toward their goal. , Research from PsychTests.com reveals ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016 ... Market by Type (Standard Pen Needles, Safety Pen Needles), ... (Insulin, GLP-1, Growth Hormone), Mode of Purchase (Retail, Non-Retail) ... MarketsandMarkets, This report studies the market for the forecast ... to reach USD 2.81 Billion by 2021 from USD ...
(Date:6/24/2016)...  Arkis BioSciences, a leading innovator in the ... cerebrospinal fluid treatments, today announced it has secured ... led by Innova Memphis, followed by Angel Capital ... Arkis, new financing will accelerate the commercialization of ... of its in-licensed Endexo® technology. ...
(Date:6/23/2016)... 23, 2016 Any dentist who has made an ... current process. Many of them do not even offer this ... and high laboratory costs involved. And those who ARE able ... such a high cost that the majority of today,s patients ... Parsa Zadeh , founder of Dental Evolutions Inc. and ...
Breaking Medicine Technology: