Navigation Links
Anti-HIV drug simulation offers 'realistic' tool to predict drug resistance and viral mutation
Date:9/2/2012

Pooling data from thousands of tests of the antiviral activity of more than 20 commonly used anti-HIV drugs, AIDS experts at Johns Hopkins and Harvard universities have developed what they say is the first accurate computer simulation to explain drug effects. Already, the model clarifies how and why some treatment regimens fail in some patients who lack evidence of drug resistance. Researchers say their model is based on specific drugs, precise doses prescribed, and on "real-world variation" in how well patients follow prescribing instructions.

Johns Hopkins co-senior study investigator and infectious disease specialist Robert Siliciano, M.D., Ph.D., says the mathematical model can also be used to predict how well a patient is likely to do on a specific regimen, based on their prescription adherence. In addition, the model factors in each drug's ability to suppress viral replication and the likelihood that such suppression will spur development of drug-resistant, mutant HIV strains.

"With the help of our simulation, we can now tell with a fair degree of certainty what level of viral suppression is being achieved how hard it is for the virus to grow and replicate for a particular drug combination, at a specific dosage and drug concentration in the blood, even when a dose is missed," says Siliciano, a professor at the Johns Hopkins University School of Medicine and a Howard Hughes Medical Institute investigator. This information, he predicts, will remove "a lot of the current trial and error, or guesswork, involved in testing new drug combination therapies."

Siliciano says the study findings, to be reported in the journal Nature Medicine online Sept. 2, should help scientists streamline development and clinical trials of future combination therapies, by ruling out combinations unlikely to work.

One application of the model could be further development of drug combinations that can be contained in a single pill
'/>"/>

Contact: David March
dmarch1@jhmi.edu
410-955-1534
Johns Hopkins Medicine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Taking Anti-HIV Meds Prior to Exposure May Help Prevent Infection
2. Hair samples from infants show exposure to anti-HIV drugs in the womb and during breast-feeding
3. Are there gender differences in anti-HIV drug efficacy?
4. American College of Cardiology cites new USF Simulation Center for Training Excellence
5. Simulation technology allows users to safely practice phacoemulsification cataract surgery
6. EliNext Completes Development of a Series of Virtual Reality Interactive 5D Simulation Games on Unity 3D
7. Advances in ataxia research to be featured at USFs Innovative Learning and Simulation Center
8. Mayo Clinic offers newly approved treatment for acid reflux disease
9. Wilderness Medicine founder offers health tips for summer season
10. Botox Offers Little Relief for Migraine, Study Finds
11. Prosthetic retina offers simple solution to restoring sight
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2015)... ... July 31, 2015 , ... That’s right, the STASH ... STASH awards? The Significant Technological Achievements in Secretive Horticulture (or STASH) Awards, featured ... tried-and-true products that have stood the test of time. These include lighting products, ...
(Date:7/31/2015)... ... July 31, 2015 , ... When the weather turned hot and ... new type of sod called Leisure Time(TM) zoysia . It's nicknamed LTZ(TM) for ... commemorate introduction of this new type of sod, Super-Sod is giving away red Adirondack ...
(Date:7/31/2015)... ... 2015 , ... Super Bowl 50 will emanate from Levi’s Stadium in Santa Clara, ... is the Super Bowl. In the two weeks that separate the conference championships and the ... 2016 Super Bowl game will mark the 50th time it has been held and the ...
(Date:7/31/2015)... ... July 31, 2015 , ... Precision Aesthetics is New York’s only Thermage ... also the first provider of Exilis non-surgical fat reduction in New York. Due ... attracted a large International clientele. Many patients travel to New York to get ...
(Date:7/31/2015)... ... July 31, 2015 , ... Last week, ... GoodThreads. The store can be accessed by visiting http://www.curemeso.org/store . , “Our ... customizable. The best part: whenever a product is purchased, the Meso Foundation receives ...
Breaking Medicine News(10 mins):Health News:The High Times S.T.A.S.H. Awards Are in, Guess Who Took Home the Prize for “Best Grow System” 2Health News:Super-Sod Introduces Leisure Time(TM) Zoysia Grass with an Adirondack Chair Promotion 2Health News:Cheap 2016 Super Bowl Tickets at Levi's Stadium: Ticket Down Slashes Ticket Prices on Super Bowl 50 Tickets in Santa Clara, CA at Levi's Stadium 2Health News:Mesothelioma Organization Launches New Store 2Health News:Mesothelioma Organization Launches New Store 3
... Claremont Lawyer Calls upon State Regulators to Impose ... Suspend Insurer,s License for Lying to State Investigators, ... litigator,William Shernoff yesterday filed a class action lawsuit ... insurer,s unlawful practice of,retroactively canceling health insurance policies ...
... Myers, Inc.,(NYSE: RBN ) announced today that it ... Capital Goods Conference in New York City on,November 28, ... Christopher M. Hix, Vice President and Chief Financial Officer, ... is set for 2:00-2:25 p.m., EST, on,Wednesday, November 28th ...
... sites nationwide , FRIDAY, Nov. 16 (HealthDay News) ... and environmental factors that may cause autism, as well ... and their families from six areas in the United ... which researchers called the largest of its kind -- ...
... Holes Between Ribs ... 1/2 Days, TYLER, Texas, Nov. 16 62-year-old Canton ... first in east,Texas to benefit from a heart bypass procedure ... Roden was released from the,hospital just 1 1/2 days after ...
... Md., Nov. 16 According to the,recently ... Study on,Attention-Deficit/Hyperactivity Disorder (MTA) in the August ... of Child and Adolescent Psychiatry,(JAACAP), children and ... medication alone or in combination with behavioral ...
... (OTC Bulletin Board: VQPH), a New Jersey-based,biopharmaceutical company ... for the three and nine months ended,September 30, ... operations,for the three months ended September 30, 2007, ... a loss of $911,125, or $0.02 per share, ...
Cached Medicine News:Health News:Health Net Hit With Class Action Alleging Unfair Business Practices Over Retroactive Cancellations of Health Insurance Policies 2Health News:Health Net Hit With Class Action Alleging Unfair Business Practices Over Retroactive Cancellations of Health Insurance Policies 3Health News:Major U.S. Autism Study Gets Under Way 2Health News:Video: Patient at Mother Frances Receives Heart Bypass Without Opening Chest 2Health News:VioQuest Pharmaceuticals Announces Third Quarter and Nine Months 2007 Results 2Health News:VioQuest Pharmaceuticals Announces Third Quarter and Nine Months 2007 Results 3Health News:VioQuest Pharmaceuticals Announces Third Quarter and Nine Months 2007 Results 4Health News:VioQuest Pharmaceuticals Announces Third Quarter and Nine Months 2007 Results 5Health News:VioQuest Pharmaceuticals Announces Third Quarter and Nine Months 2007 Results 6Health News:VioQuest Pharmaceuticals Announces Third Quarter and Nine Months 2007 Results 7
(Date:7/30/2015)... 30, 2015 Mettler-Toledo International Inc. (NYSE: ... Provided below are the highlights: , Sales ... with the prior year. Reported sales decreased 4% as ... , Net earnings per diluted share as reported ... period. Adjusted EPS was $2.80 , an increase ...
(Date:7/30/2015)... 30, 2015  Tandem Diabetes Care®, Inc. (NASDAQ: ... manufacturer of the t:slim® and t:flex™ Insulin Pumps, ... Development Agreements with Dexcom, Inc. to allow the ... the Dexcom G5 and G6 continuous glucose monitoring ... pump platform with Dexcom,s future CGM systems is ...
(Date:7/30/2015)... VANCOUVER , July 30, 2015  OncoGenex Pharmaceuticals, ... will report its second quarter 2015 financial results on ... conference call and live webcast at 4:30 p.m. Eastern ... development programs and a general corporate update. ... Investor Relations page of the OncoGenex website at ...
Breaking Medicine Technology:Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 2Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 3Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 4Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 5Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 6Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 7Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 8Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 9Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 10Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 11Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 12Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 13Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 14Tandem Diabetes Care Announces Development Agreement with Dexcom for Integration of Future Generation CGM Systems 2Tandem Diabetes Care Announces Development Agreement with Dexcom for Integration of Future Generation CGM Systems 3
... , , , , ... this month, dog owners in the Midwest will find that getting their ... the Mobile Dog Heart Health Tour will make stops with a sound-proof ... in Chicago on August 30 to perform free dog heart examinations. , ...
... REHOVOT, Israel, August 17 D-Pharm ... 85 million (approximately,$23M USD) to fund the Company,s late stage ... NIS 57 million and an Initial,Public Offering (IPO) of NIS ... set at 133 NIS, 13% higher than the minimum price. ...
Cached Medicine Technology:Midwest Mobile Dog Heart Health Tour to Provide Free Heart Examinations 2Midwest Mobile Dog Heart Health Tour to Provide Free Heart Examinations 3D-Pharm Raises NIS 85 Million in Rights Offering and Initial Public Offering (IPO) on the Tel Aviv Stock Exchange (TASE) 2D-Pharm Raises NIS 85 Million in Rights Offering and Initial Public Offering (IPO) on the Tel Aviv Stock Exchange (TASE) 3
... color monitor produces superb ... icons for easier identification ... choices for measurement. Allows ... smaller pupils than conventional ...
Auto refractometer....
Portable, easy to align, automatic measurement, automatic fogging. Accurate and dependable readings. Infrared printer communication. Rechargeable battery. Integrates with the TRS-2100 and EPIC-2100 r...
... most advanced automatic refractor/keratometer ... today. It adds the ... readings simultaneously. It also ... focusing, automatic tracking, automatic ...
Medicine Products: