Navigation Links
Anti-Clotting Drug Helps Infants With Heart Ills
Date:1/29/2008

Study shows use for small doses of Plavix in children under 2

TUESDAY, Jan. 29 (HealthDay News) -- Small doses of the anti-clotting drug clopidogrel (Plavix) can benefit children under age 2 with heart problems, a new study says.

"We were astonished at how little of the drug they needed to reap the same benefits as adults. It was only about a fifth of the amount that we were expecting," Dr. Jennifer Li, a pediatric cardiologist at Duke University Medical Center, said in a prepared statement.

For this study, sponsored by Plavix makers Bristol-Myers Squibb and Sanofi-Aventis, Li recruited 92 children with various types of heart problems that put them at high risk of developing life-threatening blood clots.

Most of the children had hypoplastic left heart syndrome, which involves a poorly functioning small ventricle that leaves children weak and blue in color. Other children had floppy or imperfect heart valves, and one had Kawasaki disease, which causes inflammation in coronary arteries. Many were facing multiple surgeries, and three-quarters already had shunts in their hearts to keep their blood flowing properly.

The children were divided into a treatment group and a placebo group. Those in the treatment group received one of four doses of clopidogrel, ranging from .01 to .20 milligrams per kilogram of body weight per day over a period of one to four weeks.

The study found that the optimal dose for infants and toddlers up to 24 months was 0.2 milligrams per day.

Adults with an average weight of 75 kilograms -- or 165 pounds -- typically receive 75 milligrams per day of clopidogrel. When extrapolated, that would predict an optimal dose of about 1 milligram per day for children under age 2.

The findings "show that you can't simply extrapolate from what you do in adults and apply it to children," Li said.

The study was published in the Jan. 29 issue of Circulation.

More information

The Nemours Foundation has more about congenital heart defects.



-- Robert Preidt



SOURCE: Duke University, news release, Jan. 23, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Possible safer target for anti-clotting drugs found
2. New Anti-Clotting Drug Shows Promise in Heart Patients
3. Researchers identify molecules with interesting anti-clotting properties
4. Anti-Clotting Drug Trial Shortened by Bleeding Problems
5. New male sling procedure helps prostate cancer survivors who suffer from urinary incontinence
6. Direct Anesthetic Infusion Helps Colorectal Cancer Patients
7. Radiation and drug combo helps boost efficacy of lung cancer treatment
8. Childs Flu Shot Helps Whole Family
9. Microsoft Helps Developers of Clinical User Interfaces Improve Efficiency, Patient Safety With Free Toolkit
10. Generic prostate drug helps find high-risk cancers early
11. Tamoxifen Helps Treat Bipolar Disorder
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Anti-Clotting Drug Helps Infants With Heart Ills
(Date:2/11/2016)... ... February 11, 2016 , ... In a ... Dallas plastic surgeon , Dr. Rod J. Rohrich, and colleagues, examine and underscore ... outlines recommendations for rhinoplasty surgeons when addressing this vital area. , The upper ...
(Date:2/11/2016)... Washington, DC (PRWEB) , ... February 11, 2016 ... ... announce an upcoming Feb. 23 webinar, “Intel’s Direct-to-Employee Benefit Model: A Case Study ... a not-for-profit Catholic health care system that’s partnering with Intel on value-based health ...
(Date:2/11/2016)... ... February 11, 2016 , ... veEDIS Clinical Systems, LLC, announced ... adaptable algorithms, has been updated to help Emergency Department physicians and nurses identify ... Zikas and a travel history to affected regions, or potential exposure through another, ...
(Date:2/11/2016)... Mount Laurel, NJ (PRWEB) , ... February 11, ... ... Commission) announces the call for nominations seeking candidates for the Board of Commissioners. ... individuals with passion, skills and experience with diversity of clinical practice settings and ...
(Date:2/11/2016)... ... February 11, 2016 , ... ... speaker, trainer and author Ray Clarke poses a question as a challenge for ... In his book, "Being in the Being" (published by Partridge Singapore), Clarke explores ...
Breaking Medicine News(10 mins):
(Date:2/11/2016)... and PORTLAND, Ore. , Feb. 11, ... company, is pleased to announce the acquisition of SolutionsRx, ... and rural access hospitals. Along with providing traditional contract ... consulting services to assist clients in navigating the complex ... , CEO of Wellpartner. --> James R. ...
(Date:2/11/2016)... SEOUL, South Korea , Feb. 11, 2016 Wearable posture tracker, ALEX , has ... project fully funded and just seven days left to go, ALEX is said to be delivered to ... http://photos.prnewswire.com/prnh/20160211/332248 ... ... ...
(Date:2/11/2016)... , 11 de fevereiro de 2016 /PRNewswire/ ... de sua fábrica de soroalbumina bovina (BSA -- ... A fábrica fica na Ilha Norte da Nova ... desenvolvido e estabelecido na fábrica da Proliant nos ... . O projeto e instalação dos equipamentos foram ...
Breaking Medicine Technology: