Navigation Links
Anti-Cholesterol Drugs Help Prevent Lung Decline
Date:10/12/2007

Statins might fight deadly pulmonary disease, experts say

FRIDAY, Oct. 12 (HealthDay News) -- Statin drugs used to lower blood cholesterol also slow the lung function loss that inevitably occurs with age and often is exacerbated by disease or smoking, researchers report.

The Harvard study included a group of more than 800 people who had their lung function measured at least twice between 1995 and 2005.

Those who were taking statins to improve their cholesterol lost lung function at about half the rate of those not using the drugs, the team reported.

"The effect was larger than I thought we would find," said Joel Schwartz, professor of environmental epidemiology at the Harvard School of Public Health, and lead author of the study, which was published in the American Journal of Respiratory and Critical Care Medicine.

In measurements of "FEV1" -- the amount of air a person can expel from the lungs in one second -- statin users lost an average of 10.9 milliliters capacity per year, compared to 23.9 milliliters annually for nonusers.

In a different measure of lung function, called forced vital capacity, statin users lost an average of 14 milliliters per year, while the loss for nonusers averaged 36.2 milliliters annually.

"It has become clear in the last five years that, in addition to lowering cholesterol, statins are potent antioxidants and reduce inflammation," Schwartz said. "Those effects are important in preventing lung function decline."

The results closely traced those of a study reported a year ago by researchers at the University of Oklahoma Medical Center. In that trial, 238 participants who took statins experienced a decline in FEV1 of 2.5 percent over an average follow-up of 2.7 years, compared to a loss averaging 12.8 percent over the same period for those not on the drugs.

That study's lead author, associate professor of medicine Dr. Jean I. Keddissi, believes the benefit stems from statins' anti-inflammatory action.

"Inflammation plays an important role in lung disease, so there is a huge potential for therapy in lung diseases such as emphysema and chronic obstructive pulmonary disease," Keddissi said.

The two trials do not yet provide nearly enough information to warrant routine use of statin therapy for lung disease, however.

"Where you go from here is a controlled clinical trial," Schwartz said. "I would think that a clinical trial doesn't seem like a risky thing, and it would get support. There are a lot of people interested in selling statins."

The potential of statin treatment seems great for chronic obstructive pulmonary disease, which affects an estimated 20 million Americans, Keddissi said.

"We have no effective treatments for COPD now," Keddissi noted. "Only bronchodilators at the start, and then oxygen."

"I wouldn't put anyone on statins at this point if they had lung disease," Keddissi said. But the Oklahoma group is taking a first step toward the use of these medications for lung trouble. "We are starting some work here in Oklahoma City, studying people with chronic obstructive pulmonary disease with statins," Keddissi said.

More information

For more on statins, head to the U.S. National Heart, Lung and Blood Institute.



SOURCES: Joel Schwartz, Ph.D., professor, environmental epidemiology, Harvard School of Public Health, Boston; Jean I. Keddissi, M.D., associate professor, medicine, University of Oklahoma Medical Center, Oklahoma City; October 2007, American Journal of Respiratory and Critical Care Medicine


'/>"/>
Copyright©2007 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Anti-cholesterol Statins May Be Helpful For Eyes Too
2. Lean Protein Could Be Key to Obesity Drugs
3. Life Saving Cancer Drugs – From Chicken! Possible Says Dolly’ Creatos
4. Nasal Spray Could Take Drugs Direct to Brain.
5. Cancer drugs in development nearly doubled since 1995
6. Cipla holds talks with mining giant to supply AIDS drugs for South African workers
7. African HIV strains more resistant to anti HIV drugs
8. Emphasis to ban Drugs ads by Doctors
9. Drugs said to Reduce HIV Transmission to Baby
10. Cholesterol Drugs Prevent Breast Cancer
11. Risky Drugs To Be Avoided In The Elderly
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/10/2016)... ... February 10, 2016 , ... Sherly Sulaiman, certified ... series of therapeutic sessions to help Los Angeles-area actors cope with rejection, improve ... The series, known as “Mindfulness for Actors and Artists,” has been featured in ...
(Date:2/10/2016)... , ... February 10, 2016 , ... LaserShip, a regional ... to the Food Bank of Eastern Michigan last Friday in order to aid in ... into the Midwest to include a facility located in Clio, only 15 miles away ...
(Date:2/10/2016)... ... February 10, 2016 , ... ... to expand dental health services to the developmentally disabled in the Coachella Valley. ... operations to a new facility at 71-949 Highway 111, Suite 100-B, in Rancho ...
(Date:2/10/2016)... ... 10, 2016 , ... As part of its ongoing series of aquatic therapy ... webinar features a dynamic expert and thoughtful presentation to give attendees a better sense ... Both events are free to attend, but registration is required. , Rehabilitation ...
(Date:2/10/2016)... ... 10, 2016 , ... Intermedix announced on Wednesday that it ... emergency medicine professional association, to support the organization's newly established physician group with ... Emergency Medicine, or AAEM, seeks to empower emergency physicians to control their own ...
Breaking Medicine News(10 mins):
(Date:2/11/2016)... a major "team investment" by Bruce Montgomery , one of this area,s most prominent biotech ... Leen Kawas , PhD. Photo - ... ... ... Kawas said the round was intended to be an $8 ...
(Date:2/11/2016)... , Feb. 11, 2016  AcelRx Pharmaceuticals, Inc. ... presentation will be made at the 38th annual ... Wound Care Symposium, which is being held February 14-18, ... conference covers the latest advancements in wound healing, burn ... American Burn Association, Australian-New Zealand Burns Association, Academy of ...
(Date:2/11/2016)... TEL AVIV, Israel , Feb. 11, 2016  Galmed ... clinical-stage biopharmaceutical company focused on the development of a ... announced today that its Chief Medical Officer, Dr. ... retiring from Galmed as Chief Medical Officer and from ... 2016 due to her reaching retirement age. ...
Breaking Medicine Technology: