Navigation Links
Anti-Cholesterol Drug May Ease Back Pain
Date:2/23/2009

Lab results suggest that Lovastatin could help with degenerative disc disease

MONDAY, Feb. 23 (HealthDay News) -- The cholesterol-lowering drug lovastatin (Mevacor) might improve outcomes for people who have surgery for degenerative disc disease, a major cause of back pain.

In an attempt to find ways to stop or reverse degenerative disc disease, orthopedic researchers have been extracting cells from disc tissue removed during surgery and cultivating the cells in the laboratory. The cells are then transferred back into patients.

In a small study, Dr. Shu-Hua Yang, chief of the department of orthopedics at National Taiwan University, and his colleagues found that lovastatin helps the differentiation of disc cells being cultivated in the lab.

The study included six people, ages 23 to 29, who were having surgery for herniated lumbar discs. The researchers removed cells from the nucleus pulposus (the jelly-like substance in the middle of a spinal disc) and added lovastatin to see if it would maximize expression of collagen II and minimize expression of collagen I, two proteins involved in bone formation.

After 72 hours, the number of nucleus pulposus cells had increased, the production of collagen II (which makes up moveable joints) had increased, and the production of collagen I (which plays a role in the development of excess fibrous connective tissues) had decreased. Lovastatin caused no harm to the nucleus pulposus cells, the researchers reported.

The findings were to be presented during the annual meeting of the Orthopaedic Research Society this week in Las Vegas.

"Regeneration of the nucleus pulposus tissue in the early stage of intervertebral disc degeneration can theoretically retard or even reverse the degenerative process and possibly regain a healthy intervertebral disc," Yang said in an American Academy of Orthopaedic Surgeons news release. "Further studies are needed to determine the potentials of statins for regeneration and repair of degenerative disc disease."

In a second study scheduled for presentation at the meeting, Yang and his team found that the tissue of younger people is generally more suitable for regeneration than tissue from older people.

More information

The North American Spine Society has more about degenerative conditions.



-- Robert Preidt



SOURCE: American Academy of Orthopaedic Surgeons, news release, Feb. 22, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Anti-Cholesterol Drugs Help Prevent Lung Decline
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Anti-Cholesterol Drug May Ease Back Pain
(Date:9/20/2017)... ... ... “Finn Mouseson”: follows the exciting story of a mouse as the need ... on a journey that will show that friends are to be gathered but home ... and illustrator, Melody Gersonde-Mickelson, who has earned a bachelor’s degree in Fine Arts from ...
(Date:9/20/2017)... ... September 20, 2017 , ... “Psalms of Humidity”: is a fascinating depiction of ... the readers one step closer to God. “Psalms of Humidity” is the creation of ... have been made within his life are the very same things that have shaped ...
(Date:9/20/2017)... ... 20, 2017 , ... “They Sang At Her Funeral”: a tale of murder ... the skeletons in their closets. “They Sang At Her Funeral” is the creation of ... and married with five children and twelve grandchildren. Before becoming a writer, Annalise had ...
(Date:9/19/2017)... ... September 19, 2017 , ... Only a few physicians were selected ... own Ross A. Clevens, MD, FACS . The founder and medical director of ... Reconstructive Surgeon who trained at Yale, Harvard and the University of Michigan. He has ...
(Date:9/19/2017)... ... 19, 2017 , ... Trusted debt-reduction firm CreditAssociates, LLC has announced two important ... excess of $835 million in resolved debt for its clients. , Credit card debt, ... the categories of debt settled by the company. With more than a decade of ...
Breaking Medicine News(10 mins):
(Date:9/7/2017)... , Sept. 7, 2017 NuvoAir (formerly ... Spirometer, announced today a partnership with Novartis Pharma AG to ... NuvoAir,s position as the leading mobile spirometry platform and Novartis, ... ... ...
(Date:9/6/2017)... PDI , a leader in infection prevention products and ... focused on the role of chlorhexidine gluconate (CHG) in ... Annual Scientific Meeting of the Association for Vascular Access. ... Phoenix Convention Center in ... feature PDI,s Prevantics® Device Swab as the ...
(Date:9/5/2017)... 2017  Getinge, a leading global provider of ... donation program -- "Color for the Kids!" -- ... research by The Children,s Heart Foundation. Pediatric patients ... are encouraged to download a coloring picture at ... to the gallery on the website. For each ...
Breaking Medicine Technology: