Navigation Links
Anti-Aging Drug Closer to Reality

Scientists extend lifespan of female mice and thwart diseases of old age in both sexes

THURSDAY, Oct. 1 (HealthDay News) -- In a possible advance toward a treatment for aging in people, researchers report that by genetically modifying mice, they reduced their susceptibility to age-related disease and expanded the lifespan of female mice by 19 percent.

Scientists have known for decades that taking in fewer calories can extend lifespan in some animals, but they have yet to figure out why that is so. In this new study, published in the Oct. 2 issue of Science, researchers manipulated mouse genes so they wouldn't produce a protein known as S6K1, thereby mimicking the effects of a strict diet.

No one knows if trying something similar in humans would slow their aging, and male mice didn't gain a longer lifespan. But researchers are hopeful, especially since the mice seemed to suffer no ill effects.

The mice were "in general, happier and healthier. We added life to their years as well as years to their lives," said study co-author Dr. Dominic J. Withers, a professor at University College London in England.

In essence, he explained, researchers have found a "mechanism" connected to the benefits of eating little that could be manipulated by existing medications. "We are therefore closer to treatments for aging and age-related diseases," he said.

At issue is finding a way to replicate the benefits of a severely restricted diet. But, keeping extremely tight control on eating can be "arduous" on a long-term basis, Withers acknowledged.

Female mice lived for an average of 950 days, 19 percent longer than usual, were skinnier and had stronger bones. They appeared to be better protected against type 2 diabetes and also appeared to be smarter: They were more "inquisitive and exploratory," Withers noted.

"Even their T cells, an important part of the immune system, appeared more 'youthful,' implying slowing of the usual age decline in immunity," he said.

The males didn't live longer but reaped other health benefits enjoyed by the females, Withers said, noting the cause of the lifespan difference is unclear.

Matt Kaeberlein, an assistant professor of pathology at the University of Washington in Seattle, said these and other new findings are shifting "the prevailing opinion among scientists working in this area [of life extension] from 'if' to 'when.'" That theory is supported by other recent life-extension research involving a drug called rapamycin and confirmation that diet restriction helps monkeys live longer, he noted.

"Most of us believe that anti-aging drugs are possible and are going to be developed from studies such as these," said Kaeberlein, co-author of a commentary accompanying the study.

So, what's next? Withers said a diabetes drug called metformin, which is marketed as Glucophage, Glumetza and Fortamet, might mimic the effects of the genetic engineering in the mice.

But, "it would take some time to work out if treating people with drugs based upon our studies actually has long-term health benefits," he said. "Clearly, undertaking such trials in humans would be a sensible next step."

More information

The Stanford Center on Longevity has more on the myths and challenges of aging.

SOURCES: Dominic J. Withers, M.D., Ph.D., professor, University College London; Matt Kaeberlein, Ph.D., assistant professor of pathology, University of Washington, Seattle; Oct. 2, 2009, Science

Copyright©2009 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Proactive Wellness Centers, PLC and Dr. Lynese Lawson Launch an All New "Anti-Aging" Blog
2. Leading Anti-Aging Prescription RENOVA(R) Continues To Deliver Maximum Results
3. Reportlinker Adds Anti-aging Products and Services: The Global Market Report
4. Resvera Health Rx Launches All-Natural Resveratrol-Based Supplement with Anti-Aging and Disease-Fighting Properties
5. Denver-Based Acupuncturist, Dr. Martha Lucas, Releases New Book: Vanity Calamity: Your Guide to Cosmetic Acupuncture for Anti-aging
6. Key protein may explain the anti-aging and anti-cancer benefits of dietary restriction
7. World Anti-Aging Congress 2009 Defies Global Economic Downturn, Demonstrating Strength of Anti-Aging Medical Movement
8. Anti-aging cosmetic reduced wrinkles in clinical trial
9. Expose on Crimes Against Humanity as Perpetrated by the Gerontological Elite Asks Is Consensus in Anti-Aging Medical Intervention An Elusive Expectation or A Realistic Goal?
10. Perlabella Introduces a Highly Concentrated and Affordable Anti-Aging Skin Care Line
11. Glissandra Skincare Inc. Launches Website Showcasing New and Novel Anti-Aging Skincare Products
Post Your Comments:
(Date:11/25/2015)... Raton, Florida (PRWEB) , ... November 25, 2015 ... ... diagnostic testing for physicians and athletic programs, launches new Wimbledon Athletics ... importance of testing young athletes for unsuspected cardiac abnormalities. About 2,000 people under ...
(Date:11/25/2015)... Calif. (PRWEB) , ... November 25, 2015 , ... Beddit® ... and Beddit Classic sleep tracking systems. The new app features a more intuitive SleepScore™ ... and understand how well you slept. The SleepScore is created by a proprietary algorithm. ...
(Date:11/25/2015)... LOUIS, Missouri (PRWEB) , ... November 25, 2015 ... ... Project HEAL, will provide scholarships for people struggling with eating disorders as a ... Proceeds from the second annual event, held at Fox Run Golf Club in ...
(Date:11/25/2015)... , ... November 25, 2015 , ... Many people know ... fuzzy-headedness, weight gain, cold hands, and dry skin. But many people who find their ... and exercise regimen instead of their thyroid, especially if they don’t have any of ...
(Date:11/24/2015)... ... 2015 , ... Genesis Chiropractic Software helps practice owners automate ... between the practice owner and the patient that automatically manages all five aspects ... Click here to learn more. , According to Dr. Brian ...
Breaking Medicine News(10 mins):
(Date:11/25/2015)... 2015  ARKRAY USA , Inc., ... evidence demonstrating the accuracy of its blood glucose meter ... Resistance, Diabetes and Cardiovascular Disease in Los ... GLUCOCARD ® 01 meter and the Assure ® ... ability to accurately measure glucose levels in blood is ...
(Date:11/25/2015)... Israel , November 25, 2015 ... KTOV ) (TASE: KTOV), a biopharmaceutical company focused ... treatment of various clinical conditions, today announced the closing ... American Depository Shares ( ADSs ), each representing 20 ... up to 3,158,900 ADSs. The ADSs and warrants were ...
(Date:11/25/2015)... DIEGO , Nov. 25, 2015  Trovagene, Inc. ... diagnostics, today announced that Chief Executive Officer Antonius Schuh, ... the 27 th Annual Piper Jaffray Healthcare Conference. ... at the New York Palace Hotel in ... at 1:30 p.m. EST. Mr. Schuh will be available ...
Breaking Medicine Technology: