Navigation Links
Anthrax capsule vaccine protects monkeys from lethal infection

Vaccination with the anthrax capsulea naturally occurring component of the bacterium that causes the diseaseprotected monkeys from lethal anthrax infection, according to U.S. Army scientists. The study, which appears in the Jan. 20th print edition of the journal VACCINE, represents the first successful use of a non-toxin vaccine to protect monkeys from the disease.

Bacillus anthracis, the bacterium that causes anthrax, is recognized as one of the most serious bioterrorism threats. It produces three main components that allow it to do harmlethal toxin, edema toxin, and the capsule. During anthrax infection, the bacterium invades and grows to high concentrations in the host. The capsule surrounds the bacterium and prevents it from being ingested and destroyed by the white blood cells, thus allowing anthrax infection to progress. The toxins are thought to act mainly by damaging the body's natural defense mechanisms.

Current human vaccines for anthrax are based on the protective antigen, or PA, component of the anthrax toxins. Scientists at the U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID) have extensively studied protective antigen, demonstrating that PA alone confers protection in animal challenge studies with both rabbits and monkeys.

However, according to senior author Arthur M. Friedlander of USAMRIID, concerns about reliance on a single antigenas well as the issue of protecting against anthrax strains that may be vaccine resistanthave prompted the search for additional vaccine components. Bacterial capsules are commonly used in licensed vaccines for other diseases, including certain types of pneumonia and meningitis.

Friedlander's group had already demonstrated, in published mouse studies, that the anthrax capsule plays a role in conferring protection. In their current work, the team describes testing the capsule vaccine in both rabbits and monkeys against an aerosol challenge with anthrax spores. The vaccine induced anti-capsule antibody responses in both species. While rabbits were not protected against a high aerosol challenge dose, a significant number of the monkeys who received the capsule vaccine survived.

"This is the first non-toxin anthrax vaccine shown to be protective in monkeys," Friedlander said. "In addition, this new capsule vaccine is expected to work against possible vaccine-resistant strains of anthrax, as well as in recipients whose immune systems may not respond to protective antigen alone."

The results suggest that addition of capsule to protective antigen to create a multi-component vaccine may broaden and enhance the protection afforded by protective antigen-based vaccines. Friedlander said the next step would be to do a larger study in monkeys looking at varying doses of the capsule vaccine.

Contact: Caree Vander Linden
US Army Medical Research Institute of Infectious Diseases

Related medicine news :

1. Natural killer cells could be key to anthrax defense
2. Community storage of anthrax-preventing antibiotics should be determined by state
3. Bacillus anthracis and Anthrax
4. Poll: Hypothetical anthrax attack and antibiotics
5. A Capsule Camera Instead of a Colonoscopy?
6. Coffee in capsules contains more furan than the rest
7. Novel brain tumor vaccine acts like bloodhound to locate cancer cells
8. Potential Herpes Vaccine Disappoints Researchers
9. Many Teen Girls Mistakenly Think HPV Vaccines Cut Risk for All STDs
10. Research shows progress toward a genital herpes vaccine
11. Novel Hepatitis C Vaccine Shows Some Early Promise
Post Your Comments:
(Date:6/26/2016)... ... ... Kasmer, a legally blind and certified personal trainer is helping to develop a weight loss ... plans to fix the two major problems leading the fitness industry today:, ... , They don’t eliminate all the reasons people quit their exercise program ...
(Date:6/25/2016)... ... ... "With 30 hand-drawn hand gesture animations, FCPX users can easily customize each ... Film Studios. , ProHand Cartoon’s package transforms over 1,300 hand-drawn pictures into hand ... select a ProHand generator and drag it above media or text in the Final ...
(Date:6/25/2016)... ... June 25, 2016 , ... Conventional wisdom preaches the benefits of moderation, ... the latter, setting the bar too high can result in disappointment, perhaps even self-loathing. ... toward their goal. , Research from reveals that behind the ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... Scientific Sessions in Dallas that it will receive two significant new grants to ... came as PHA marked its 25th anniversary by recognizing patients, medical professionals and ...
(Date:6/24/2016)... ... June 24, 2016 , ... People across the U.S. ... magazine’s Code Talker Award, an essay contest in which patients and their families pay ... be presented at the 2016 National Society of Genetic Counselors (NSGC) Annual Education Conference ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... Belgium , June 24, 2016 ... the appointment of Dr. Edward Futcher ... Non-Executive Director, effective June 23, 2016.Dr. Futcher was ... Nominations and Governance Committees.  As a non-executive member ... independent expertise and strategic counsel to VolitionRx in ...
(Date:6/23/2016)... 23, 2016 Any dentist who has made an ... current process. Many of them do not even offer this ... and high laboratory costs involved. And those who ARE able ... such a high cost that the majority of today,s patients ... Parsa Zadeh , founder of Dental Evolutions Inc. and ...
(Date:6/23/2016)... , June 23, 2016 Research and ... Devices Medical Market Analysis 2016 - Forecast to 2022" ... The report contains up to date financial data derived ... Assessment of major trends with potential impact on the market ... of market segmentation which comprises of sub markets, regional and ...
Breaking Medicine Technology: