Navigation Links
Anthrax capsule vaccine protects monkeys from lethal infection
Date:1/12/2012

Vaccination with the anthrax capsulea naturally occurring component of the bacterium that causes the diseaseprotected monkeys from lethal anthrax infection, according to U.S. Army scientists. The study, which appears in the Jan. 20th print edition of the journal VACCINE, represents the first successful use of a non-toxin vaccine to protect monkeys from the disease.

Bacillus anthracis, the bacterium that causes anthrax, is recognized as one of the most serious bioterrorism threats. It produces three main components that allow it to do harmlethal toxin, edema toxin, and the capsule. During anthrax infection, the bacterium invades and grows to high concentrations in the host. The capsule surrounds the bacterium and prevents it from being ingested and destroyed by the white blood cells, thus allowing anthrax infection to progress. The toxins are thought to act mainly by damaging the body's natural defense mechanisms.

Current human vaccines for anthrax are based on the protective antigen, or PA, component of the anthrax toxins. Scientists at the U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID) have extensively studied protective antigen, demonstrating that PA alone confers protection in animal challenge studies with both rabbits and monkeys.

However, according to senior author Arthur M. Friedlander of USAMRIID, concerns about reliance on a single antigenas well as the issue of protecting against anthrax strains that may be vaccine resistanthave prompted the search for additional vaccine components. Bacterial capsules are commonly used in licensed vaccines for other diseases, including certain types of pneumonia and meningitis.

Friedlander's group had already demonstrated, in published mouse studies, that the anthrax capsule plays a role in conferring protection. In their current work, the team describes testing the capsule vaccine in both rabbits and monkeys against an aerosol challenge with anthrax spores. The vaccine induced anti-capsule antibody responses in both species. While rabbits were not protected against a high aerosol challenge dose, a significant number of the monkeys who received the capsule vaccine survived.

"This is the first non-toxin anthrax vaccine shown to be protective in monkeys," Friedlander said. "In addition, this new capsule vaccine is expected to work against possible vaccine-resistant strains of anthrax, as well as in recipients whose immune systems may not respond to protective antigen alone."

The results suggest that addition of capsule to protective antigen to create a multi-component vaccine may broaden and enhance the protection afforded by protective antigen-based vaccines. Friedlander said the next step would be to do a larger study in monkeys looking at varying doses of the capsule vaccine.


'/>"/>
Contact: Caree Vander Linden
caree.vanderlinden@us.army.mil
301-619-2285
US Army Medical Research Institute of Infectious Diseases
Source:Eurekalert

Related medicine news :

1. Natural killer cells could be key to anthrax defense
2. Community storage of anthrax-preventing antibiotics should be determined by state
3. Bacillus anthracis and Anthrax
4. Poll: Hypothetical anthrax attack and antibiotics
5. A Capsule Camera Instead of a Colonoscopy?
6. Coffee in capsules contains more furan than the rest
7. Novel brain tumor vaccine acts like bloodhound to locate cancer cells
8. Potential Herpes Vaccine Disappoints Researchers
9. Many Teen Girls Mistakenly Think HPV Vaccines Cut Risk for All STDs
10. Research shows progress toward a genital herpes vaccine
11. Novel Hepatitis C Vaccine Shows Some Early Promise
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... ... June 26, 2016 , ... Pixel Film Studios Released ProSlice ... "Film editors can give their videos a whole new perspective by using the ... of Pixel Film Studios. , ProSlice Levels contains over 30 Different presets to ...
(Date:6/26/2016)... ... June 26, 2016 , ... ... have been diagnosed with endometriosis. These women need a treatment plan to not ... comprehensive approach that can help for preservation of fertility and ultimately achieving a ...
(Date:6/25/2016)... Miami, FL (PRWEB) , ... June 25, 2016 , ... The temporary closing of Bruton ... Plant City Observer , brings up a new, often overlooked aspect of head lice: ... The closing for fumigation is not a common occurrence, but a necessary one in the ...
(Date:6/25/2016)... ... 2016 , ... As a lifelong Southern Californian, Dr. Omkar Marathe earned his ... David Geffen School of Medicine at UCLA. He trained in Internal Medicine at Scripps ... in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he had the opportunity to ...
(Date:6/25/2016)... ... 2016 , ... Conventional wisdom preaches the benefits of moderation, whether it’s a ... the bar too high can result in disappointment, perhaps even self-loathing. However, those who ... , Research from PsychTests.com reveals that behind the tendency to set ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... and INDIANAPOLIS , June ... receiving a Lilly Diabetes Tomorrow,s Leaders Scholarship is any ... scholarship winners, announced today online at www.diabetesscholars.org ... type 1 diabetes stand in the way of academic ... supported the Foundation,s scholarship program since 2012, and continues ...
(Date:6/23/2016)... 23, 2016  Guerbet announced today that it has ... Horizon Award . One of 12 suppliers ... for its support of Premier members through exceptional local ... and commitment to lower costs. ... of our outstanding customer service from Premier," says ...
(Date:6/23/2016)... , June 23, 2016  Experian ... integrating and transforming the patient payment and ... several innovative new products and services that ... its revenue cycle offerings. These award-winning solutions ... efficient workflows, remain compliant in an ever-changing ...
Breaking Medicine Technology: