Navigation Links
Anthrax capsule vaccine protects monkeys from lethal infection
Date:1/12/2012

Vaccination with the anthrax capsulea naturally occurring component of the bacterium that causes the diseaseprotected monkeys from lethal anthrax infection, according to U.S. Army scientists. The study, which appears in the Jan. 20th print edition of the journal VACCINE, represents the first successful use of a non-toxin vaccine to protect monkeys from the disease.

Bacillus anthracis, the bacterium that causes anthrax, is recognized as one of the most serious bioterrorism threats. It produces three main components that allow it to do harmlethal toxin, edema toxin, and the capsule. During anthrax infection, the bacterium invades and grows to high concentrations in the host. The capsule surrounds the bacterium and prevents it from being ingested and destroyed by the white blood cells, thus allowing anthrax infection to progress. The toxins are thought to act mainly by damaging the body's natural defense mechanisms.

Current human vaccines for anthrax are based on the protective antigen, or PA, component of the anthrax toxins. Scientists at the U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID) have extensively studied protective antigen, demonstrating that PA alone confers protection in animal challenge studies with both rabbits and monkeys.

However, according to senior author Arthur M. Friedlander of USAMRIID, concerns about reliance on a single antigenas well as the issue of protecting against anthrax strains that may be vaccine resistanthave prompted the search for additional vaccine components. Bacterial capsules are commonly used in licensed vaccines for other diseases, including certain types of pneumonia and meningitis.

Friedlander's group had already demonstrated, in published mouse studies, that the anthrax capsule plays a role in conferring protection. In their current work, the team describes testing the capsule vaccine in both rabbits and monkeys against an aerosol challenge with anthrax spores. The vaccine induced anti-capsule antibody responses in both species. While rabbits were not protected against a high aerosol challenge dose, a significant number of the monkeys who received the capsule vaccine survived.

"This is the first non-toxin anthrax vaccine shown to be protective in monkeys," Friedlander said. "In addition, this new capsule vaccine is expected to work against possible vaccine-resistant strains of anthrax, as well as in recipients whose immune systems may not respond to protective antigen alone."

The results suggest that addition of capsule to protective antigen to create a multi-component vaccine may broaden and enhance the protection afforded by protective antigen-based vaccines. Friedlander said the next step would be to do a larger study in monkeys looking at varying doses of the capsule vaccine.


'/>"/>
Contact: Caree Vander Linden
caree.vanderlinden@us.army.mil
301-619-2285
US Army Medical Research Institute of Infectious Diseases
Source:Eurekalert

Related medicine news :

1. Natural killer cells could be key to anthrax defense
2. Community storage of anthrax-preventing antibiotics should be determined by state
3. Bacillus anthracis and Anthrax
4. Poll: Hypothetical anthrax attack and antibiotics
5. A Capsule Camera Instead of a Colonoscopy?
6. Coffee in capsules contains more furan than the rest
7. Novel brain tumor vaccine acts like bloodhound to locate cancer cells
8. Potential Herpes Vaccine Disappoints Researchers
9. Many Teen Girls Mistakenly Think HPV Vaccines Cut Risk for All STDs
10. Research shows progress toward a genital herpes vaccine
11. Novel Hepatitis C Vaccine Shows Some Early Promise
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/21/2017)... ... ... the largest manufacturer of oats in China, is now aiming at global business expansion, ... globally as one of the healthiest cereals, XieQingkui, the founder of Seamild, strongly recommends ... sow the seed of good karma. Buddhism spirit featuring benevolence and sacrifice are the ...
(Date:1/21/2017)... , ... January 21, 2017 , ... ... Alumni Relations, Dianne Travis-Teague, the electrifying line-up of events for its annual meeting ... family, friends, and community. “Coming Home 2017” will be held on Friday ...
(Date:1/21/2017)... Santa Rosa, CA (PRWEB) , ... January 21, ... ... announce the opening of its new medical office in Petaluma, located at 167 ... full-service casting room, access to SRO sports medicine and rehabilitation services ...
(Date:1/21/2017)... ... January 21, 2017 , ... The Nobel Biocare™ dental implant ... media for its creos™ line of bone regenerative products. Specifically, the ... he utilizes creos™ allo.gain™ bone graft for a variety of bone reconstruction procedures. ...
(Date:1/20/2017)... ... ... A new partnership between Goodwill® and Roadie, Inc. aims to make it easier ... couches to dressers and bicycles. Roadie — the national on-the-way delivery network — will ... through February 28th. , “January is an exciting time when resolutions are made ...
Breaking Medicine News(10 mins):
(Date:1/21/2017)... , Jan. 20, 2017 ARMO BioSciences, Inc., ... data on the Company,s lead investigational immuno-oncology drug AM0010 ... by the American Society of Clinical Oncology (ASCO), taking ... CA. "AM0010 induces the ... + T cells in the blood and tumors ...
(Date:1/20/2017)... Research and Markets has announced the ... HGB/HCT, BMP, BUN Creatinine, Electrolyte Testing, HbA1c Testing, Comprehensive Metabolic Panel, ... 2013 - 2024" report to their offering. ... The global clinical laboratory testing ... Introduction of innovative solutions on the grounds of maximum efficiency ...
(Date:1/20/2017)... -- Research and Markets has announced the addition ... Future" report to their offering. ... This research service on the global pharmaceutical ... provides a snapshot of the key participants in the market. ... from 2016 to 2020. The market is expected to grow at ...
Breaking Medicine Technology: