Navigation Links
Another clue to how obesity works

The effects of obesity - both on our bodies and on the health budget - are well known, and now, scientists are getting closer to understanding how the disease progresses, providing clues for future treatments.

In a study, published today in the prestigious journal Cell Metabolism, researchers at Monash University in collaboration with colleagues in the United States, have revealed how resistance to the hormone leptin, a key causal component of obesity, develops.

Lead author Professor Tony Tiganis, of the Monash Obesity and Diabetes Institute and Monash University's Department of Biochemistry and Molecular Biology, said our bodies produce leptin in response to increasing fat deposits.

"Acting on a part of the brain called the hypothalamus, leptin instructs the body to increase energy expenditure and decrease food intake, and so helps us maintain a healthy body weight," said Professor Tiganis.

"The body's response to leptin is diminished in overweight and obese individuals, giving rise to the concept of 'leptin-resistance'. We've discovered more about how 'leptin-resistance' develops, providing new directions for research into possible treatments."

Two proteins are already known to inhibit leptin in the brain and Professor Tiganis' team have discovered a third. In mice, this third protein becomes more abundant with weight-gain, exacerbating leptin-resistance and hastening progression to morbid obesity. The study showed that the three negative regulators of leptin take effect at different stages, shedding light on how obesity progresses.

"Drugs targeting one of the negative regulators are already in clinical trials for Type 2 Diabetes, however, our research shows that in terms of increasing leptin-sensitivity in obesity, targeting only one of these won't be enough. All three regulators might need to be switched off," said Professor Tiganis.

The study showed that high fat diet-induced weight gain is largely prevented in genetically-modified mice when two of the negative regulators are deleted in the brain.

"We now have to determine what happens when all three negative regulators are neutralised. Do we prevent high fat diet-induced obesity?"

Professor Tiganis said the more that is known about obesity, the better equipped scientists are to develop drugs to support good diet and exercise choices.

"Humans have a deep-seated attraction to overeating and nutrient-rich food, inherited from our hunter-gatherer ancestors. Now that food is more readily available and our lifestyles are less active, our evolutionary drive to overeat is becoming problematic."

More than four million Australians are obese and if current trends continue, by 2020, more than 80 per cent of adults and almost one third of children will be overweight or obese. Studies indicate that obesity and related health issues cost Australians more than $56 billion a year.

"Simply telling people to eat less and exercise more is not going to be sufficient to reverse the obesity trend. There is a pressing need to develop novel drugs that complement diet and exercise to both prevent and treat this disease," said Professor Tiganis.

Contact: Emily Walker
Monash University

Related medicine news :

1. As One Life Starts, Another May Be Saved
2. No One Treatment for Acid Reflux Clearly Better Than Another: Study
3. Another Blood Test for Alzheimers Shows Promise
4. FDA Approves Another New Drug to Fight Hepatitis C
5. Study suggests another look at testosterone-prostate cancer link
6. FDA approval of brain aneurysm device gives Jefferson neurosurgeons another life-saving tool
7. Tufts biologists find another clue to the origins of degenerative diseases
8. Penn study suggests another avenue for detecting Alzheimers disease
9. Polluted Air Another Danger to U.S. Troops in Iraq
10. Scientists Spot Another Gene Behind Type 2 Diabetes
11. Generic drug may improve the effectiveness of cancer nanotherapies
Post Your Comments:
(Date:6/25/2016)... ... ... First Choice Emergency Room , the largest network of independent freestanding ... of its new Mesquite-Samuell Farm facility. , “We are pleased to announce Dr. ... James M. Muzzarelli, Executive Medical Director of First Choice Emergency Room. , Dr. ...
(Date:6/25/2016)... ... June 25, 2016 , ... ... recover from injury. Recently, he has implemented orthobiologic procedures as a method for ... is one of the first doctors to perform the treatment. Orthobiologics are substances ...
(Date:6/25/2016)... , ... June 25, 2016 , ... Conventional wisdom preaches ... success. In terms of the latter, setting the bar too high can result in ... than just slow progress toward their goal. , Research from ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... Those who ... with these feelings, many turn to unhealthy avenues, such as drug or alcohol abuse, ... Marne, Michigan, has released tools for healthy coping following a traumatic event. , Trauma ...
(Date:6/24/2016)... ... , ... Marcy was in a crisis. Her son James, eight, was out of control. Prone ... physically. , “When something upset him, he couldn’t control his emotions,” remembers Marcy. “If ... at my other children and say he was going to kill them. If we ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... 24, 2016 According to a ... (Standard Pen Needles, Safety Pen Needles), Needle Length (4mm, ... Hormone), Mode of Purchase (Retail, Non-Retail) - Trends & ... studies the market for the forecast period of 2016 ... 2.81 Billion by 2021 from USD 1.65 Billion in ...
(Date:6/24/2016)... , June 24, 2016 VolitionRx ... of Dr. Edward Futcher to the ... effective June 23, 2016.Dr. Futcher was also appointed ... Governance Committees.  As a non-executive member of the ... and strategic counsel to VolitionRx in connection with ...
(Date:6/23/2016)... 2016  MedSource announced today that it has ... solution of choice.  This latest decision demonstrates MedSource,s ... their clients by offering a state-of-the-art electronic data ... nowEDC as the EDC platform of choice in ... "nowEDC has long been a preferred EDC platform ...
Breaking Medicine Technology: