Navigation Links
Another Study Supports Early HIV Therapy

New British findings echo those of an American team

THURSDAY, April 9 (HealthDay News) -- Antiretroviral treatment for HIV should begin earlier than it does for many patients, say researchers who analyzed data on more than 45,000 HIV-infected patients in Europe and North America.

The new findings come on the heels of a similar study, reported last week in the New England Journal of Medicine. In that study, researchers at the University of Washington, Seattle, found that starting therapy earlier -- before the body's immune system is too badly weakened -- rather than later in the infection process, boosted survival by up to 94 percent.

There's ongoing debate about when it's best to initiate HIV therapy. If treatment begins too late, treatment may not be as effective. But starting antiretroviral treatment early may increase the drugs' toxic effects.

The new findings, published online Wednesday in The Lancet, suggest that the minimum CD4-cell count threshold for the start of combination antiretroviral therapy should be 350 cells per microliter of blood, which is at the upper limit of levels for starting this drug regimen as currently recommended in many countries.

Levels of CD4 immune T-cells in the blood are considered an indicator of HIV's advance, with lower cell counts signaling that the virus has progressed.

Jonathan Sterne, of the University of Bristol in the United Kingdom, and colleagues found that deferring therapy until a CD4-cell count reached 251 to 350 cells per microliter was associated with a 28 percent higher rate of AIDS and death, compared to commencing therapy when the CD4-cell count was at a higher level of 351 to 450 cells per microliter.

Based on the findings, the researchers concluded that 350 cells per microliter should be the minimum threshold at which antiretroviral therapy is started.

"Our findings should help to guide physicians and patients in deciding when to start antiretroviral treatment," the researchers wrote.

They noted that the "International AIDS Society USA panel recommended in August, 2008, that antiretroviral therapy is started in individuals with CD4-cell counts less than 350 cells per microliter, and that this decision should be individualized when the CD4-cell count is greater than 350 cells per microliter. Recent US and European guidelines make similar recommendations."

"Unfortunately, many patients are not diagnosed with HIV until their CD4 count has fallen well below 350 cells per microliter, sometimes even below 200 cells per microliter," the UK team said. "It is important that people at possible risk of having HIV get tested regularly so that if found to be infected they can receive the necessary care and treatment."

But, two experts noted in an accompanying editorial that "the question of when to start ART might have more than one right answer," especially in poorer countries where access to medical resources is limited.

World Health Organization "guidelines for resource-limited settings currently recommend initiation of [antiretroviral therapy] before blood CD4 counts fall below 200 cells per microliter, with an upper threshold of 350 cells per microliter," they wrote. "To inform these recommendations, randomized controlled trials should include patients living in resource-limited settings." The editorial was written by Dr. Robin Wood, of the Desmond Tutu HIV Center at the University of Cape Town, South Africa, and Dr. Stephen D. Lawn, of the center and the London School of Hygiene and Tropical Medicine.

More information

The U.S. National Institute of Allergy and Infectious Diseases has more about HIV treatment.

-- Robert Preidt

SOURCE: The Lancet, news release, April 8, 2009

Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. American College of Pediatricians: Another Blow to Childrens Rights
2. TRICOR Systems Inc. Receives ISO 13485 Certification; Contract Manufacturer Achieves Another Significant Milestone in 32 Year History
3. Set Up Your Computer to Work in Another Language – New Tips at
4. Pennsylvanians Encouraged to Take Another Look at COBRA Options
5. Is one diet as good as another? U of I study says no and tells you why
6. Acuo Technologies(R) Announces Another Record Sales and Implementation Growth
7. Exacerbations in COPD: One thing leads to another
8. Medical research community needs to speak louder to prevent another Canadian brain drain
9. Agresso Wins Another $1 Million+ Deal in Health Care Sector
10. Another reason to get your hands dirty
11. Another reason to avoid high-fat diet -- it can disrupt our biological clock
Post Your Comments:
Related Image:
Another Study Supports Early HIV Therapy
(Date:10/13/2015)... Nashville, Tennessee (PRWEB) , ... October 13, 2015 ... ... owned leader of anesthesia and pain management services, today announced its partnership with ... the partnership integrates data from disparate systems and organizes the data into an ...
(Date:10/13/2015)... ... October 13, 2015 , ... ProText Kinetic Panel is ... With ProText Kinetic Panel, users can create energetic text animations in any layout without ... the Final Cut Pro X timeline and stylize the text. With intuitive on-screen controls, ...
(Date:10/13/2015)... ... October 13, 2015 , ... Element ... products, introduced a new company, RightSensor™ LLC, an Internet of Things (IoT) hardware ... RightSensor™ provides a fully-managed approach for customers requiring sensor hardware for critical data ...
(Date:10/13/2015)... CA (PRWEB) , ... October 13, 2015 , ... Dr. ... by Medical New Today on September 18, 2015. The research, which was conducted at ... Dr. Wael Sabbah and colleagues, show connections between stress during pregnancy and future dental ...
(Date:10/13/2015)... (PRWEB) , ... October 13, 2015 , ... A child ... that’s why SmileCareClub , the leading remote invisible aligner system, has joined with ... would otherwise go without it. For each aligner treatment plan purchased, SmileCareClub will donate ...
Breaking Medicine News(10 mins):
(Date:10/13/2015)... , Oct. 13, 2015  Mylan N.V. (Nasdaq: ... 5:00 p.m. ET host a conference call and webcast to ... plc (NYSE: PRGO ; TASE) shareholders through Mylan,s offer ... Mylan,s Executive Chairman Robert J. Coury , CEO ... --> --> Mylan will ...
(Date:10/13/2015)... -- Synapse Biomedical Inc. ( ) reported today that ... use of the NeuRx ® Diaphragm Pacing System ... the United States and patient ... PAS study group met their initial enrollment goal ahead ... expanded the enrollment target to 150 participants.   ...
(Date:10/13/2015)... COLLEGE PARK, Md. , Oct. 13, 2015 ... hubs is the biggest key to growing Baltimore ... to a report released today by the Maryland Technology ... already has many of the pieces in place to support ... Martha Connolly , director of Mtech Baltimore. "This study is ...
Breaking Medicine Technology: