Navigation Links
Another McGill/JGH breakthrough opens door to early Alzheimer's diagnosis
Date:6/16/2009

A new diagnostic technique which may greatly simplify the detection of Alzheimer's disease has been discovered by researchers at McGill University and the affiliated Lady Davis Institute for Medical Research at Montreal's Jewish General Hospital (JGH). Their results were published June 8 in the Journal of Alzheimer's Disease. There is currently no accepted blood test for Alzheimer's, and the diagnosis is usually based on expensive and labour-intensive neurological, neuropsychological and neuroimaging evaluations.

Dr. Hyman Schipper and colleagues at the Lady Davis Institute and McGill University utilized a new minimally-invasive technique called near-infrared (NIR) biospectroscopy to identify changes in the blood plasma of Alzheimer's patients, changes which can be detected very early after onset, and possibly in pre-clinical stages of the disease.

Biospectroscopy is the medical form of spectroscopy, the science of detecting the composition of substances using light or other forms of energy. In NIR spectroscopy, different substances emit or reflect light at specific, detectable wavelengths.

In this study, Schipper and his colleague Dr. David Burns head of McGill's Biomedical Laboratory for Informatics, Imaging and Spectroscopy at the department of chemistry applied near-infrared light to blood plasma samples taken from patients with early Alzheimer's dementia, mild cognitive impairment (MCI) == an intermediate state between normal cognition and dementia -- and healthy elderly control subjects at the JGH/McGill Memory Clinic. Using this technique, the researchers were able to distinguish Alzheimer's from healthy controls with 80 per cent sensitivity (correct identification of patients with the disease) and 77 per cent specificity (correct identification of persons without the disease). A significant number of subjects with MCI tested positively with the Alzheimer group, indicating that the test may be capable of detecting Alzheimer disease even before patients' symptoms meet clinical criteria for dementia.

"We are very encouraged by these data and look forward to testing this potential diagnostic tool in larger-scale studies", said Schipper, Director of the Centre for Neurotranslational Research at the JGH and professor of neurology and medicine at McGill. Researchers have been searching for a minimally-invasive biological marker that differentiates Alzheimer's disease from normal aging and other neurodegenerative conditions for decades.

"The advent of a simple blood test for the diagnosis of early Alzheimer's", remarked Schipper, "would represent a major achievement in the management of this common disorder".


'/>"/>

Contact: Mark Shainblum
mark.shainblum@mcgill.ca
514-398-2189
McGill University
Source:Eurekalert

Related medicine news :

1. Another Reason Not to Smoke While Pregnant: Birth Defects
2. One Species Genome Found Within Another
3. Eat Seafood, See Weight Loss: Recent Study Finds Another Reason to Eat Seafood for a Fit Lifestyle
4. Message for Activists at Latino National Congreso Convention: Amnesty Will Exacerbate National Problems and Turn the U.S. into Another Mexico
5. Latest Edition of Ripon Forum Highlights Schwarzeneggers Leadership on Another Challenge Facing his State - Health Care
6. Beckman Coulter Signs Agreements With Amerinet, Inc.; Ten-Year Partnership Extended for Another Three Years
7. Portico(TM) Systems Charts Another Period of Rapid Growth
8. Another Medtronic Sprint Fidelis Lead Lawsuit is Filed in Federal District Court
9. FDA Sunscreen Labeling Decision Delayed Another Month, Leading U.S. Physician to Say, Enough Is Enough
10. Another smart cancer drug can have toxic effects on the heart
11. Teen Pregnancy Epidemic Another Reason for Women to Carry Condoms. Just in Case, Inc. Announces 10,000 Chic Condom Compact Give-Away to Womens Non-Profits Nationwide.
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/9/2016)... (PRWEB) , ... December 09, 2016 , ... ... Ball at The Pierre Hotel in New York, NY, on December 3rd, to ... dignitaries and physicians attended the annual event, which raised over $1 million - ...
(Date:12/8/2016)... WV (PRWEB) , ... December 08, 2016 , ... ... it will become Quality Insights beginning January 1, 2017. The name change ... its commitment to measuring and improving health care quality. , “We are very ...
(Date:12/8/2016)... ... 08, 2016 , ... ZyDoc , a New York-based ... Data Capture Methods for Input to Electronic Health Records: A Comparative Usability Study” ... comparative usability study demonstrate that a dictation-based method (“NLP Entry”) using ZyDoc’s MediSapien™ ...
(Date:12/8/2016)... ... 2016 , ... With the increasing demand for dental implants, the National Association ... to inform dentists and patients about the safety issues related to dental restorations. According ... the U.S. is projected to reach $6.4 billion in 2018 with more than 30 ...
(Date:12/8/2016)... ... December 08, 2016 , ... ... continuity to its innovative Unified Instance Manager architecture, meeting the needs of ... new version optimizes the unattended auto-dialing system without agents, Presence Robodialer, provides ...
Breaking Medicine News(10 mins):
(Date:12/8/2016)... VIEW, Calif. , Dec. 8, 2016 IRIDEX ... intends to offer newly issued shares of common stock, $0.01 ... pursuant to an underwritten public offering.  The final terms of ... the time of pricing, and there can be no assurance ... IRIDEX expects to use the net proceeds it ...
(Date:12/8/2016)... Australia Glaucoma Surgery Devices Market Outlook ... "Australia Glaucoma Surgery Devices Market Outlook to 2022", ... Surgery Devices market. The report provides value, in ... average prices (USD) within market segement - Glaucoma ... shares and distribution shares data for each of ...
(Date:12/8/2016)... -- The global biosurgery market is expected to grow at ... 2016 to 2021. The market is poised to reach ... in 2016. The market is primarily driven by rising ... and spinal problems, increasing clearance of biosurgery products by ... management. In this report, the biosurgery market ...
Breaking Medicine Technology: