Navigation Links
Another Genetic Link to Testicular Cancer Is Found
Date:7/2/2009

Discovery may help explain why disease runs in families,,

THURSDAY, July 2 (HealthDay News) -- A second gene linked to inherited testicular germ-cell cancer has been identified by scientists at the U.S. National Institutes of Health.

"This study contributes to our understanding of why testicular germ-cell cancer appears to run in families," Dr. Raynard Kington, acting NIH director, said in an agency news release. "The findings may also lead to new ways to identify men at high risk, as well as more effective ways to prevent and treat testicular germ-call cancer."

The U.S. National Cancer Institute estimates that 8,400 men will be diagnosed with testicular cancer this year, and that about 90 percent of the cases will be germ-cell cancers.

For the study, the scientists analyzed DNA from 95 familial testicular cancer patients and found seven different mutations in a gene called PDE11A. Healthy men did not have the mutations.

"The mutations don't cause cancer directly, but instead appear to increase an individual's susceptibility to developing a tumor," the study's senior author, Dr. Constantine Stratakis, chief of the endocrinology and genetics section at the National Institute of Child Health and Human Development, said in the news release.

The PDE11A gene is located in a key biochemical pathway in testicular germ-cell cancer, the cyclic AMP pathway, which regulates how cells respond to such signals as hormones. Drugs that affect the AMP pathway are widely available and, in theory, may help slow progression of testicular cancer.

Learning more about how mutations in PDE11A affect testicular cancer risk could help scientists identify other proteins that also play a role in the disease, Stratakis said.

The study is in the July issue of Cancer Research.

PDE11A is also highly expressed in the prostate gland, so Stratakis and colleagues are now studying the frequency
'/>"/>

Copyright©2009 ScoutNews,LLC.
All rights reserved  

Page: 1 2

Related medicine news :

1. Another McGill/JGH breakthrough opens door to early Alzheimers diagnosis
2. Clearly Contacts Announces Another Quarter Of Growth In The Economic Downturn
3. Another Blood Fat Fuels Heart Attack Risk
4. Wall Street Not Affecting Mainstreet Property Group; Group Breaks Ground on Another Senior Care Campus in Lafayette, IN
5. NYU School of Medicine pathology researchers solve another mystery in B lymphocyte development
6. Hyperferritinemia is another surrogate marker of advanced liver disease
7. New Study Shows Women Experience Significantly Less Unscheduled Bleeding With the ORTHO TRI-CYCLEN(R) LO Birth Control Pill Versus Another Pill
8. Womens Gynecological Exams: Another Victim of the Troubled Economy?
9. Another Study Supports Early HIV Therapy
10. American College of Pediatricians: Another Blow to Childrens Rights
11. TRICOR Systems Inc. Receives ISO 13485 Certification; Contract Manufacturer Achieves Another Significant Milestone in 32 Year History
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Another Genetic Link to Testicular Cancer Is Found
(Date:8/31/2015)... ... August 31, 2015 , ... Diablo Publications (DP), ... it has officially launched a new website and company identity ( diablopublications.com) . ... more closely aligned with the company’s strategic vision for growth and expansion over ...
(Date:8/31/2015)... ... August 31, 2015 , ... Finnleo is pleased to ... Outdoor Sauna. After months of extensive engineering and design of our newest sauna model, ... the elements and is offered at a very attractive price-point. , Before outdoor ...
(Date:8/31/2015)... ... 31, 2015 , ... Wyoming Medical Center, an acute care ... Clinical Documentation Improvement (CDI) and medical coding needs. Based on a proprietary Natural ... is an enterprise-level coding solution that combines CDI, Coding, Quality and Compliance Auditing ...
(Date:8/31/2015)... ... , ... Castle Dermatology Institute now welcomes San Fernando Valley skin doctor ... the University of California, Los Angeles. He graduated summa cum laude with a Bachelor ... Medical School. As a nationally recognized Regents Scholar, Dr. Ghasri was given numerous honors ...
(Date:8/31/2015)... ... 2015 , ... “My mother and husband use oxygen therapy and the tubing ... there could be a comfortable way to prevent the irritation, so I invented this.” ... a more secure way to anchor the cannula tubing used in oxygen therapy and ...
Breaking Medicine News(10 mins):Health News:Diablo Publications Launches New Company Website 2Health News:Diablo Publications Launches New Company Website 3Health News:Say “Hello” to the Brand New Finnleo Terrace Outdoor Saunas 2Health News:Wyoming Medical Center Selects ezDI’s CAC/CDI Solution Based on Integrated Healthcare Data Management, Workflow Design and ROI 2Health News:Wyoming Medical Center Selects ezDI’s CAC/CDI Solution Based on Integrated Healthcare Data Management, Workflow Design and ROI 3Health News:Wyoming Medical Center Selects ezDI’s CAC/CDI Solution Based on Integrated Healthcare Data Management, Workflow Design and ROI 4Health News:Castle Dermatology Institute Now Welcomes Dr. Pedram Ghasri to the Practice 2Health News:InventHelp® Inventor Designs Nasal Cannula Ear Protector (AVZ-1217) 2
... 2008 South African scientists will gain access ... through an agreement announced today by the European ... Republic of South Africa signed a cooperation agreement ... intergovernmental funding body for EMBO, allowing scientists from ...
... to Rally Residents to Eat Right, Move More and ... Milk Their Diets, ... and downs of different fad diets -- which seem to go in and ... out of three Americans remain overweight or obese., A new campaign crossing ...
... System adds a smile to children, families traveling to and from ... ... Tenn., June 5 3-1-1 Travel,Bag, Inc., a developer of practical carry-on ... Bag,System toiletry cases for families traveling to and from St. Jude,Children,s Research ...
... Tufts University researcher Bess Dawson-Hughes, M.D., chaired ... Osteoporosis Foundation (NOF) Clinician,s Guide to Prevention ... Clinician,s Guide incorporates the World Health Organization ... computer-based tool expected to increase the identification ...
... Inc.,(Nasdaq: NUVO ) today announced the publication ... showing that the R-spondin family of,proteins activate the ... for,cell growth and differentiation during homeostasis and pathogenesis. ... proteins, and,modulated the Wnt pathway by a common ...
... N.J., June 5 Senesco,Technologies, Inc. ("Senesco" or ... details of its continuing preclinical multiple myeloma research. ... animal studies,in which Senesco,s Factor 5A technology, encapsulated ... myeloma tumors when injected,intratumorally., Senesco has continued ...
Cached Medicine News:Health News:Message to Denver Residents: Forgo Fad Dieting and Join the Campaign for Healthy Weight 2Health News:Message to Denver Residents: Forgo Fad Dieting and Join the Campaign for Healthy Weight 3Health News:Message to Denver Residents: Forgo Fad Dieting and Join the Campaign for Healthy Weight 4Health News:3-1-1 Travel Bag Donates to St. Jude Children's Research Hospital 2Health News:Tufts researcher leads revision of osteoporosis guidelines 2Health News:Tufts researcher leads revision of osteoporosis guidelines 3Health News:Nuvelo Announces Publication of Preclinical Data From Wnt Therapeutics Program 2Health News:Nuvelo Announces Publication of Preclinical Data From Wnt Therapeutics Program 3Health News:Senesco Expands on Preclinical Multiple Myeloma Findings 2Health News:Senesco Expands on Preclinical Multiple Myeloma Findings 3
(Date:8/31/2015)... Vascular Ltd., together with its subsidiaries (the "Company" ... the "Group"), a global company engaged in the ... for the minimally invasive treatment of vascular disease, ... ("BTK") cohort of patients in the Chocolate® Balloon ... 15, 2015 at the 5th Annual Amputation Prevention ...
(Date:8/31/2015)... Aug. 31, 2015   BioLife Solutions , ... manufacturer and marketer of proprietary clinical grade cell ... cryopreservation freeze media and a related ... for smart shippers ("BioLife" or the ... an advanced biopharmaceutical company focused on developing and ...
(Date:8/30/2015)... GENEVA, Switzerland , August 31, 2015 ... join healthbank to ... healthbank , the world,s first citizen-owned health data transaction ... and Netcetera to engineer and bring ...      (Logo: http://photos.prnewswire.com/prnh/20150828/261966) , "Our business ...
Breaking Medicine Technology:Final Results From Below-The-Knee Cohort In Chocolate Registry Presented At The 5th Annual Amputation Prevention Conference 2Final Results From Below-The-Knee Cohort In Chocolate Registry Presented At The 5th Annual Amputation Prevention Conference 3Final Results From Below-The-Knee Cohort In Chocolate Registry Presented At The 5th Annual Amputation Prevention Conference 4BioLife Solutions Customer TiGenix Phase 3 Clinical Trial Meets Primary Endpoint 2BioLife Solutions Customer TiGenix Phase 3 Clinical Trial Meets Primary Endpoint 3BioLife Solutions Customer TiGenix Phase 3 Clinical Trial Meets Primary Endpoint 4BioLife Solutions Customer TiGenix Phase 3 Clinical Trial Meets Primary Endpoint 5healthbank Announces Strategic Partnerships to Bring to Market Global Health Data Transaction Platform 2healthbank Announces Strategic Partnerships to Bring to Market Global Health Data Transaction Platform 3healthbank Announces Strategic Partnerships to Bring to Market Global Health Data Transaction Platform 4
... IRVINE, Calif., Dec. 13, 2010 Masimo ... that a new clinical study demonstrating the accuracy of ... presented last week at the American Association of ... in Las Vegas. The largest gathering of respiratory care ...
... Texas, Dec. 13, 2010 Ascension Orthopedics, Inc., a ... implantation of the PyroTITAN™ Humeral Resurfacing Implant in France. ... from painful primary arthritis with synovial osteochondromotosis at Imperial ... first in continental Europe. The patient was discharged from ...
Cached Medicine Technology:New Clinical Study Presented at the American Association of Respiratory Care Finds Masimo Rainbow Acoustic Monitoring Accurate for Respiration Rate Assessment 2New Clinical Study Presented at the American Association of Respiratory Care Finds Masimo Rainbow Acoustic Monitoring Accurate for Respiration Rate Assessment 3New Clinical Study Presented at the American Association of Respiratory Care Finds Masimo Rainbow Acoustic Monitoring Accurate for Respiration Rate Assessment 4New Clinical Study Presented at the American Association of Respiratory Care Finds Masimo Rainbow Acoustic Monitoring Accurate for Respiration Rate Assessment 5New Clinical Study Presented at the American Association of Respiratory Care Finds Masimo Rainbow Acoustic Monitoring Accurate for Respiration Rate Assessment 6Ascension Orthopedics Implants PyroTITAN™ in France 2
... It is powerful, lightweight, ... comfortable, soft, durable foam ... pad, covered by machine ... Flexible headband easily adjusts ...
Xenon surgical headlight system is durable, comfortable, lightweight and deliver dependable bright light through a patented shielded fiber optic bundle. It is easy to wear....
Solarc surgical headlight is durable, comfortable, lightweight and delivers the bright, white light expected from a xenon system, but at a fraction of the cost....
View Mex-3 is designed for out-patient surgery, hospital rounds and house calls....
Medicine Products: