Navigation Links
Another Genetic Link to Testicular Cancer Is Found
Date:7/2/2009

Discovery may help explain why disease runs in families,,

THURSDAY, July 2 (HealthDay News) -- A second gene linked to inherited testicular germ-cell cancer has been identified by scientists at the U.S. National Institutes of Health.

"This study contributes to our understanding of why testicular germ-cell cancer appears to run in families," Dr. Raynard Kington, acting NIH director, said in an agency news release. "The findings may also lead to new ways to identify men at high risk, as well as more effective ways to prevent and treat testicular germ-call cancer."

The U.S. National Cancer Institute estimates that 8,400 men will be diagnosed with testicular cancer this year, and that about 90 percent of the cases will be germ-cell cancers.

For the study, the scientists analyzed DNA from 95 familial testicular cancer patients and found seven different mutations in a gene called PDE11A. Healthy men did not have the mutations.

"The mutations don't cause cancer directly, but instead appear to increase an individual's susceptibility to developing a tumor," the study's senior author, Dr. Constantine Stratakis, chief of the endocrinology and genetics section at the National Institute of Child Health and Human Development, said in the news release.

The PDE11A gene is located in a key biochemical pathway in testicular germ-cell cancer, the cyclic AMP pathway, which regulates how cells respond to such signals as hormones. Drugs that affect the AMP pathway are widely available and, in theory, may help slow progression of testicular cancer.

Learning more about how mutations in PDE11A affect testicular cancer risk could help scientists identify other proteins that also play a role in the disease, Stratakis said.

The study is in the July issue of Cancer Research.

PDE11A is also highly expressed in the prostate gland, so Stratakis and colleagues are now studying the frequency of PDE11A mutations in men with prostate cancer.

More information

The American Cancer Society has more about testicular cancer.



-- Robert Preidt



SOURCE: U.S. National Institutes of Health, news release, June 29, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Another McGill/JGH breakthrough opens door to early Alzheimers diagnosis
2. Clearly Contacts Announces Another Quarter Of Growth In The Economic Downturn
3. Another Blood Fat Fuels Heart Attack Risk
4. Wall Street Not Affecting Mainstreet Property Group; Group Breaks Ground on Another Senior Care Campus in Lafayette, IN
5. NYU School of Medicine pathology researchers solve another mystery in B lymphocyte development
6. Hyperferritinemia is another surrogate marker of advanced liver disease
7. New Study Shows Women Experience Significantly Less Unscheduled Bleeding With the ORTHO TRI-CYCLEN(R) LO Birth Control Pill Versus Another Pill
8. Womens Gynecological Exams: Another Victim of the Troubled Economy?
9. Another Study Supports Early HIV Therapy
10. American College of Pediatricians: Another Blow to Childrens Rights
11. TRICOR Systems Inc. Receives ISO 13485 Certification; Contract Manufacturer Achieves Another Significant Milestone in 32 Year History
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Another Genetic Link to Testicular Cancer Is Found
(Date:6/24/2016)... ... June 24, 2016 , ... Those who have experienced traumatic events may suffer ... unhealthy avenues, such as drug or alcohol abuse, as a coping mechanism. To avoid ... healthy coping following a traumatic event. , Trauma sufferers tend to feel a range ...
(Date:6/24/2016)... ... ... Marcy was in a crisis. Her son James, eight, was out of control. Prone to ... , “When something upset him, he couldn’t control his emotions,” remembers Marcy. “If there ... my other children and say he was going to kill them. If we were ...
(Date:6/24/2016)... ... 24, 2016 , ... Global law firm Greenberg Traurig, P.A. announced that 20 ... by their peers for this recognition are considered among the top 2 percent of ... honors as members of this year’s Legal Elite Hall of Fame: Miami Shareholders ...
(Date:6/24/2016)... ... June 24, 2016 , ... Comfort Keepers® of San Diego, CA is excited ... To Recovery® program to drive cancer patients to and from their cancer treatments. ... highest quality of life and ongoing independence. Getting to and from medical treatments ...
(Date:6/24/2016)... ... June 24, 2016 , ... People across the U.S. ... magazine’s Code Talker Award, an essay contest in which patients and their families pay ... be presented at the 2016 National Society of Genetic Counselors (NSGC) Annual Education Conference ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... June 24, 2016 Research ... "Structural Electronics 2015-2025: Applications, Technologies, Forecasts" ... In-Mold Electronics, Smart Skin, Structural Health ... Structural electronics involves electronic and/or electrical ... structures, replacing dumb structures such as vehicle bodies ...
(Date:6/24/2016)... June 24, 2016 Dehaier Medical Systems Ltd. ... which develops, markets and sells medical devices and wearable ... signed a strategic cooperation agreement with Hongyuan Supply Chain ... Chain") on June 20, 2016, to develop Dehaier,s new ... cooperation agreement, Dehaier will leverage Hongyuan Supply Chain,s sales ...
(Date:6/24/2016)... , June 24, 2016 Research ... World Market for Companion Diagnostic Tests" report to their ... Market for Companion Diagnostics The World Market ... and personalized medicine diagnostics. Market analysis in the report includes ... Test Market (In Vitro Diagnostic Kits) by Region (N. America, ...
Breaking Medicine Technology: