Navigation Links
Another Genetic Link to Testicular Cancer Is Found
Date:7/2/2009

Discovery may help explain why disease runs in families,,

THURSDAY, July 2 (HealthDay News) -- A second gene linked to inherited testicular germ-cell cancer has been identified by scientists at the U.S. National Institutes of Health.

"This study contributes to our understanding of why testicular germ-cell cancer appears to run in families," Dr. Raynard Kington, acting NIH director, said in an agency news release. "The findings may also lead to new ways to identify men at high risk, as well as more effective ways to prevent and treat testicular germ-call cancer."

The U.S. National Cancer Institute estimates that 8,400 men will be diagnosed with testicular cancer this year, and that about 90 percent of the cases will be germ-cell cancers.

For the study, the scientists analyzed DNA from 95 familial testicular cancer patients and found seven different mutations in a gene called PDE11A. Healthy men did not have the mutations.

"The mutations don't cause cancer directly, but instead appear to increase an individual's susceptibility to developing a tumor," the study's senior author, Dr. Constantine Stratakis, chief of the endocrinology and genetics section at the National Institute of Child Health and Human Development, said in the news release.

The PDE11A gene is located in a key biochemical pathway in testicular germ-cell cancer, the cyclic AMP pathway, which regulates how cells respond to such signals as hormones. Drugs that affect the AMP pathway are widely available and, in theory, may help slow progression of testicular cancer.

Learning more about how mutations in PDE11A affect testicular cancer risk could help scientists identify other proteins that also play a role in the disease, Stratakis said.

The study is in the July issue of Cancer Research.

PDE11A is also highly expressed in the prostate gland, so Stratakis and colleagues are now studying the frequency of PDE11A mutations in men with prostate cancer.

More information

The American Cancer Society has more about testicular cancer.



-- Robert Preidt



SOURCE: U.S. National Institutes of Health, news release, June 29, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Another McGill/JGH breakthrough opens door to early Alzheimers diagnosis
2. Clearly Contacts Announces Another Quarter Of Growth In The Economic Downturn
3. Another Blood Fat Fuels Heart Attack Risk
4. Wall Street Not Affecting Mainstreet Property Group; Group Breaks Ground on Another Senior Care Campus in Lafayette, IN
5. NYU School of Medicine pathology researchers solve another mystery in B lymphocyte development
6. Hyperferritinemia is another surrogate marker of advanced liver disease
7. New Study Shows Women Experience Significantly Less Unscheduled Bleeding With the ORTHO TRI-CYCLEN(R) LO Birth Control Pill Versus Another Pill
8. Womens Gynecological Exams: Another Victim of the Troubled Economy?
9. Another Study Supports Early HIV Therapy
10. American College of Pediatricians: Another Blow to Childrens Rights
11. TRICOR Systems Inc. Receives ISO 13485 Certification; Contract Manufacturer Achieves Another Significant Milestone in 32 Year History
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Another Genetic Link to Testicular Cancer Is Found
(Date:5/26/2017)... ... May 26, 2017 , ... Leading ... 2017 on May 30th and 31st at The Four Seasons Hotel Boston. ... in the life sciences, offering exclusive access to key decision makers who influence ...
(Date:5/26/2017)... ... May 26, 2017 , ... Amir Qureshi, MD is the first physician ... spinal cord stimulation system. The Nuvectra™ Algovita SCS System has been FDA approved as ... the first in Arkansas to introduce the most powerful SCS system and the only ...
(Date:5/26/2017)... ... ... A new analysis of community health data reveals that four out of the ... the average cost of healthcare rising and the U.S. senior population expected to double ... of where they live. An annual 2017 report looked at a variety of community ...
(Date:5/26/2017)... ... 26, 2017 , ... via seating is proud to partner ... chair specifically designed for clinical areas. Genie Copper Mesh is a crossover chair ... to provide customers with a game changing chair that is affordably priced,” Chas ...
(Date:5/26/2017)... ... May 26, 2017 , ... After raising nearly $30,000 on Kickstarter ... to be available at a discounted crowdfunding price on Indiegogo . , “Along ... I also wanted to bring a fidget toy to the market that was made ...
Breaking Medicine News(10 mins):
(Date:5/10/2017)... , May 10, 2017 Radiology has become ... its costs have also spiraled to the number one ... to radiology than ever before as the most complete ... a patient with lower back pain an MRI may ... reason for pain, resulting in entirely different treatment protocols.  ...
(Date:5/9/2017)...  Semler Scientific, Inc. (OTCQB: SMLR), an emerging ... the clinical effectiveness and efficiency of healthcare providers, ... ended March 31, 2017. "We ... identify when preventive care options are appropriate, which ... attacks or strokes occur," said Doug Murphy-Chutorian ...
(Date:5/6/2017)...  Hill-Rom Holdings, Inc. (NYSE: HRC), has begun a ... to its Welch Allyn campus. The ... more than 100 new jobs to Central ... a significant presence for more than 100 years. Hill-Rom,s ... large portion of which will be R&D and engineering ...
Breaking Medicine Technology: