Navigation Links
Another Blood Fat Fuels Heart Attack Risk
Date:6/9/2009

Danish study fingers high levels of lipoprotein(a)

TUESDAY, June 9 (HealthDay News) -- Yet another type of blood fat may be linked to higher cardiac risk, a new study suggests.

A Danish study finds an increased risk of heart attacks in people whose genes give them high blood levels of a cholesterol-related blood fat, lipoprotein(a), but the researchers say more work is needed to justify treatment to reduce those levels.

"We show that those with the 10 percent highest lipoprotein(a) have a two- to threefold increased risk of myocardial infarction [heart attack], similar to that for the highest LDL cholesterol levels," said Dr. Borge G. Nordestgaard, a professor of clinical biochemistry at Copenhagen University, and lead author of a report in the June 10 issue of the Journal of the American Medical Association.

However, a large-scale trial is needed to tell whether drugs aimed at reducing lipoprotein(a) (LPA) levels would lower the risk, Nordestgaard said. One compound, niacin, also known as nicotinic acid or vitamin B3, is known to reduce LPA levels, he said.

"I am not aware of other drugs being developed to lower lipoprotein(a), but I certainly hope that our study will make big pharmaceutical companies interested in developing such drugs," Nordestgaard said.

LPA consists of a molecule of LDL cholesterol, the "bad" kind that clogs arteries, attached to a number of units of protein. The number of protein units attached to the LDL unit can vary widely.

Nordestgaard and his colleagues have been studying the relationship of LPA to heart disease for years. Their latest report uses data from three studies that included more than 40,000 Danes, with follow-up periods as long as 16 years.

"We observed an increase in risk of myocardial infarction with increased levels of lipoprotein(a)," the researchers wrote. The risk was highest in people whose LPA had a smaller number of lipoprotein attachments, they noted.

Caution is needed in interpreting the results because all the people in the studies were white, Nordestgaard said. "People of African descent have the highest lipoprotein(a) levels, while those of European descent and most Asians have similar levels, but lower levels than blacks," he noted.

The studies of LPA levels and heart disease in ethnic groups other than whites have been limited, Nordestgaard said. "It is likely that high lipoprotein(a) levels are also important in other ethnic groups, but we need new and much larger studies to confirm this," he said.

The findings could influence medical efforts to reduce heart attack risk, Nordestgaard said. "People who develop heart attacks despite cholesterol-lowering statin treatment may have high levels of lipoprotein(a)," he said. "Also, in medium-risk individuals, an elevated lipoprotein(a) level may suggest that the patient should be given a statin or niacin."

The new study is "an elegant biological demonstration of the link between lipoprotein(a) and heart attack," said Dr. Christopher J. O'Donnell, associate director of the U.S. National Heart, Lung, and Blood Institute's Framingham Heart Study, and co-author of an accompanying editorial

"But it doesn't alter the balance of evidence that to date doesn't support doing a test on the serum level or a genetic test for LPA," O'Donnell said. "There would have to be some type of evidence that direct treatment of LPA lowers the risk or that a subgroup of people with an elevated risk have their risk lowered in some way."

Such evidence would have to come from a truly large-scale study, O'Donnell said. "We would have to screen an entire population," he said. Meanwhile, there is "no compelling evidence" that LPA-lowering therapy would affect coronary risk, he said.

More information

The means and meaning of testing LPA levels are described by U.S. National Library of Medicine.



SOURCES: Borge G. Nordestgaard, M.D., professor, clinical biochemistry, Copenhagen, Denmark; Christopher J. O'Donnell, M.D., associate director, U.S. National Heart, Lung, and Blood Institute Framingham Heart Study; June 10, 2009, Journal of the American Medical Association


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Wall Street Not Affecting Mainstreet Property Group; Group Breaks Ground on Another Senior Care Campus in Lafayette, IN
2. NYU School of Medicine pathology researchers solve another mystery in B lymphocyte development
3. Hyperferritinemia is another surrogate marker of advanced liver disease
4. New Study Shows Women Experience Significantly Less Unscheduled Bleeding With the ORTHO TRI-CYCLEN(R) LO Birth Control Pill Versus Another Pill
5. Womens Gynecological Exams: Another Victim of the Troubled Economy?
6. Another Study Supports Early HIV Therapy
7. American College of Pediatricians: Another Blow to Childrens Rights
8. TRICOR Systems Inc. Receives ISO 13485 Certification; Contract Manufacturer Achieves Another Significant Milestone in 32 Year History
9. Set Up Your Computer to Work in Another Language – New Tips at Argotrans.com
10. Pennsylvanians Encouraged to Take Another Look at COBRA Options
11. Is one diet as good as another? U of I study says no and tells you why
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Another Blood Fat Fuels Heart Attack Risk
(Date:2/13/2016)... ... , ... The producers of Enterprises TV are pleased to present ... world of instantaneous consumption proves very convenient for businesses. With new technologies constantly becoming ... which pollutes our air, water, and soil. It can also threaten the lives of ...
(Date:2/13/2016)... ... 13, 2016 , ... DDi , a Makro company, ... for its expertise in eClinical Solutions. DDi has built its solution competency with ... of global clients. DDi provides smarter technology for Clinical Development, Regulatory and Enterprise ...
(Date:2/12/2016)... ... February 12, 2016 , ... ... to funding innovative lymphoma research and serving the lymphoma community through a comprehensive ... members of South Florida’s philanthropic community at its 10th anniversary Fashion Luncheon on ...
(Date:2/12/2016)... ... February 12, 2016 , ... Coco Libre, the maker ... Red Carpet Events LA GRAMMY’s Style Lounge Event. Coco Libre will offer musicians and ... hydrated before the big event. The invitation-only gifting suite, held this year at the ...
(Date:2/12/2016)... (PRWEB) , ... February 12, 2016 , ... Fisher House ... Vegas Mayor John J. Lee, Nevada Military Support Alliance president Scott Bensing, and Peggy ... at the VA Southern Nevada Healthcare System. This will be the first Fisher ...
Breaking Medicine News(10 mins):
(Date:2/12/2016)... Feb. 12, 2016   National Community Pharmacists Association ... MBA issued the following statement today in response to ... the Centers for Medicare & Medicaid Services (CMS) ... beneficiary advocates and others: patient advocacy organizations ... still reviewing the full CMS analysis. Our initial reaction ...
(Date:2/12/2016)... , Feb. 12, 2016  Diplomat Pharmacy, Inc. (NYSE: DPLO ) is pleased to ... Account Management and Payor Strategies effective Jan. 23, 2016. ... ... ... Diplomat Specialty Pharmacy ...
(Date:2/12/2016)... MONTREAL , February 12, 2016 ... sofern nicht anders vermerkt)   ... Unternehmens http://www.telestatherapeutics.com abrufbar.    ... Website des Unternehmens http://www.telestatherapeutics.com ... Inc. (TSX:TST; PNK:BNHLF) veröffentlichte heute seinen Konzernabschluss ...
Breaking Medicine Technology: