Navigation Links
Annals of Internal Medicine tip sheet for June 19, 2012, online issue
Date:6/18/2012

1. Hospitalization Often Catastrophic for Alzheimer Patients

Hospitalization of patients with Alzheimer disease (AD) often leads to complications such as delirium, loss of independence, institutionalization, and death. Researchers theorized that AD patients who suffer an episode of delirium during hospitalization are at increased risk for adverse outcomes. In a prospective study, researchers reviewed 15 years of medical records for a cohort of 771 patients aged 65 or older with a clinical diagnosis of AD to determine which patients, and under what circumstances, had hospitalization, delirium, death, and/or institutionalization. The records showed that 48 percent of the study patients were hospitalized and 25 percent developed delirium during their stay. While hospitalized patients without delirium had a substantially increased risk for death and institutionalization, those with delirium had an even higher risk. Further research is needed to understand whether delirium is only a signal that precedes decline for patients with AD or if preventing it can reduce adverse outcomes.


2. Osteoarthritis Treatment, Flavocoxid, Linked to Significant Liver Injury

Osteoarthritis is a common and potentially debilitating joint disorder caused by aging and regular wear and tear. Painkillers prescribed for osteoarthritis offer limited pain relief and are associated with adverse events. Flavocoxid is a proprietary medical food that is marketed to treat osteoarthritis. A medical food is a specially formulated supplement used to manage diseases with specific nutritional requirements that cannot be met through normal diet. Unlike drug treatments, medical foods can be marketed without clinical trials proving safety and efficacy. In this case series, the authors describe characteristics of patients with acute liver injury that is suspected to have been caused by flavocoxid. Among 877 patients enrolled in the Drug-Induced Liver Injury Network Prospective Study, four developed symptoms and signs of liver injury within three months after initiating flavocoxid. The four patients all females between the ages of 57 and 68 were evaluated to determine the likely cause of their liver injury. The researchers concluded that flavocoxid was very likely to be the cause in three patients and was possibly the cause in one patient. For all four patients, the liver injury resolved within weeks of cessation. According to the authors of an accompanying editorial, patients often consider medical foods and food supplements to be "natural", so they may not disclose use of medical foods with their physician. The editorialists caution that physicians should discourage their patients from using any kind of medical food or supplement until policies related to marketing are changed to include safety and efficacy trials.


3. Patients with Alcoholic Cirrhosis Probably Won't Die from Liver Cancer

Screening These Patients for Liver Cancer Not Likely to Save Lives, Unlikely to be Cost-effective

Patients with alcoholic cirrhosis have an increased risk for liver cancer. It has been suggested that screening for liver cancer in this population may save lives, yet no randomized trials have examined the effect of liver cancer screening on total mortality or liver cancer-related mortality in patients with alcoholic cirrhosis. Researchers in Denmark studied a nationwide registry of patients hospitalized with a first-time diagnosis of alcoholic cirrhosis from 1993 to 2005. Among 8,482 patients, 169 developed liver cancer, and 5,734 died, 151 of whom had liver cancer. The incidence and mortality of liver cancer was no greater in the alcoholic cirrhosis patients than those in the nationwide cohort. The researchers conclude that screening for liver cancer in alcoholic cirrhosis patients would not decrease the high mortality in this population, nor would it be cost-effective.


'/>"/>

Contact: Abbey Anderson
aanderson@acponline.org
215-351-2656
American College of Physicians
Source:Eurekalert

Related medicine news :

1. Annals of Internal Medicine tip sheet for May 8, 2012, online issue
2. May/June 2012 Annals of Family Medicine tip sheet
3. Embargoed news from Annals of Internal Medicine
4. Internal medicine physician specialists release policy paper on reforming Medicaid
5. US Army internal medicine Masters, Fellows honored by American College of Physicians
6. US Army internal medicine residents receive awards from American College of Physicians
7. Surgeon General receives 2012 Distinguished Public Service Award from internal medicine physicians
8. First targeted nanomedicine to enter human clinical studies
9. Normalizing tumor blood vessels improves delivery of only the smallest nanomedicines
10. AFAR announces the 2012 Hartford Centers of Excellence in Geriatric Medicine awards
11. DNA Testing Finds Allergens, Toxins in Traditional Chinese Medicines
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/30/2020)... ... ... Worldwide Business with kathy ireland® will be LIVE streaming this week’s episode ... at 8:00pm ET / PT – two chances to watch each night! This episode’s exclusive ... Diagnostic Solutions Laboratory . , As leaders in their industries, these three ...
(Date:5/30/2020)... ... May 29, 2020 , ... In appreciation for all the dedication ... James Hodge Hyundai is offering a $500 bonus towards the lease or purchase of ... now through January 4, 2021. , To qualify for this offer, individuals must be ...
(Date:5/28/2020)... ... May 28, 2020 , ... Officials with ... clinically integrated network (CIN) and the group purchasing organization run by Allegheny Health ... establish a heart failure program at Mon Health Medical Center. ...
(Date:5/28/2020)... , ... May 28, 2020 , ... ... fully re-open in the fall, operators of student housing are scrambling to implement ... COCM, which manages over 37,000 student housing beds on 38 campuses across the ...
(Date:5/27/2020)... (PRWEB) , ... May 27, 2020 , ... The podiatrists ... curve and Howell Michigan, Fowlerville Michigan , and Ann Arbor Michigan. Dr. ... all high-risk patients within the clinic and at the hospital. We have been seeing ...
Breaking Medicine News(10 mins):
(Date:6/3/2020)... ... 2020 , ... The Conference Forum announced the launch of the first virtual ... September 21st, 2020. This annual conference challenges biopharma R&D on how to embrace, adapt ... to participate in clinical research. , “This event comes at a critical time,” says ...
(Date:6/3/2020)... ... June 03, 2020 , ... ... 75, announced today the addition of connected device capabilities to its mobile device ... The expanded capabilities come at a time when an increasing number of home ...
(Date:6/2/2020)... ... June 02, 2020 , ... As the leading human capital ... COVID-19 it is working with its corporate team, its consultants, and its healthcare ... host of digital resources. Harmony’s leadership team recognized the extraordinary efforts of the ...
Breaking Medicine Technology: