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Annals of Internal Medicine tip sheet for 1 Jan. 2013
Date:12/31/2012

Administering a quadruple dose of seasonal flu vaccine may help better protect HIV-infected patients from serious illness or death from influenza. In a randomized, double-blind, controlled trial, 190 HIV-positive adults were randomly assigned to receive either a standard dose (15 mcg of antigen per strain) or a high dose (60 mcg/strain) of the influenza trivalent vaccine. Participants were included if they were indicated for a flu vaccine and were receiving stable antiretroviral therapy as recommended by current guidelines. The researchers found that the high dose patients achieved greater immune response as measured by their levels of seroprotective antibodies at 21 to 28 days after vaccination. Adverse event rates were similar in the two intervention groups. According to the researchers, these findings could have implications for future vaccination efforts in the HIV-positive population.

Note: For an embargoed PDF, contact Megan Hanks or Angela Collom. You can reach the lead author directly at Pablo.Tebas@uphs.upenn.edu or 215-615-4321.


3. Observation Article: Foodborne Illness Could Have Sinister Causes

Doctors should consider the intentional addition of medicine to food as a potential cause of foodborne disease outbreaks. The World Health Organization suggests possible sources of foodborne disease outbreaks are pathogenic bacteria, viruses, protozoa, parasitic worms, natural toxins, and chemicals, but not medicines. A 2010 foodborne disease outbreak in Beijing, China was a result of clonidine, a medication used to treat hypertension and ADHD, being intentionally added to lunch ingredients. Eighty travelers who had just finished lunch in a Beijing restaurant began to feel faint. Within a few hours they developed dizziness, weakness, lethargy, dry mouth, and nausea, among other troublesome symptoms. At a nearby hospital, the travelers were treated for low blood p
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Contact: Angela Collom
acollom@acponline.org
215-351-2653
American College of Physicians
Source:Eurekalert

Page: 1 2 3 4

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