Navigation Links
Animal results may pave way to treating rare mitochondrial diseases in children
Date:5/19/2011

the levels of coenzyme Q10 within the animals' tissues and corrected signaling abnormalities.

"This drug showed remarkable benefits in the mice, especially when compared to directly feeding the mice supplements of the missing co-factorcoenzyme Q10," said Falk. "If this approach can be safely translated to humans, we may have a more effective treatment for mitochondrial disease than anything currently being used."

Primary coenzyme Q deficiency is vanishingly rare in humansonly a few dozen people are known to have the disease. However, said Falk, the disease is representative of a more common group of inherited, hard-to-treat mitochondrial diseases called respiratory chain (RC) defects.

RC defects share a common cellular failure to properly consume oxygen for the purposes of generating energy. Such defects, caused by a wide range of genetic disorders that affect mitochondria, constitute a common culprit in human mitochondrial disease. "If using probucol or a similar drug can benefit patients with defects in the respiratory chain, this could be a significant advance in treating mitochondrial diseases," said Falk.

At the very least, added Falk, the current study increases basic understanding of the biology of mitochondrial disease. She noted that continuing research building on her team's findings may set the stage for eventual clinical trials using this approach.


'/>"/>

Contact: Dana Mortensen
Mortensen@email.chop.edu
267-426-6092
Children's Hospital of Philadelphia
Source:Eurekalert

Page: 1 2

Related medicine news :

1. New clues found linking larger animals to colder climates
2. Ghrelin mitigates liver fibrosis in animal models; regulates human fibrosis
3. ATTENTION: Pawty Animals Needed in Nashville, Tennessee
4. Second Dose of Gene Therapy for Inherited Blindness Proves Safe in Animal Studies
5. Promega - TOP srl Agreement Enables Live Animal Imaging for Cancer Studies
6. Delray Beach and Boca Raton Veterinarian Launches New Web Sites for Atlantic Animal Hospital
7. Gunther von Hagens BODY WORLDS of Animals Opening March 19 at the Neunkirchen Zoo
8. Scout's House™ Announces Nation's First Animal Physical Rehabilitation Therapy Consultation Service for Veterinarians
9. 'Animals' Keep Germs Away From Kids' Toothbrushes
10. Science Reveals Secrets of Animals Spots, Stripes
11. The effect of dietary supplements, acids and animal protein on gastrointestinal disorders
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/25/2014)... TX (PRWEB) December 26, 2014 The ... to 2023” focuses on the current treatment landscape, unmet ... cancer market. TS-1 is an anti-cancer drug which is ... orally and is also used for treating gastric cancer ... and otastat potassium. The drug was first approved in ...
(Date:12/25/2014)... December 25, 2014 The short film “Color ... created in honor of a true 9/11 hero, Welles Remy ... festivals including the 24 hours of Nuremberg International Short Film ... , Actress, screenwriter and director Luciana Lagana ... film together with her husband, Gregory Graham - ...
(Date:12/25/2014)... Recently, LunaDress.co.uk has updated its blog to provide professional shopping ... of the models at LunaDress.co.uk come with big discounts, up to ... veil can turn out to be a most exciting memory and ... always bring surprise to a wedding. On the updated fashion blog, ... veils for a big day . , Going out with friends ...
(Date:12/25/2014)... By Dennis Thompson ... -- Researchers could be closing in on a "fountain of ... improve the health of older adults, a new study suggests. ... when given a drug that targets a genetic signaling pathway ... maker Novartis report. The experimental medication, a ...
(Date:12/25/2014)... Carolina (PRWEB) December 25, 2014 ... Carolina Retirement Community, recently showed their generous spirit ... of the Catawba County Parenting Network- Grandparents Raising ... 10 children gathered around the largest Christmas tree ... open presents purchased by residents of the Abernethy ...
Breaking Medicine News(10 mins):Health News:TS-1 Colorectal Cancer Market Analysis and Forecast to 2023 Report at RnRMarketReserach.com 2Health News:TS-1 Colorectal Cancer Market Analysis and Forecast to 2023 Report at RnRMarketReserach.com 3Health News:The True 9/11 Hero Story “Color of Honor” Premieres in Germany and Bangladesh: Luciana Lagana Plays the Mother of the Lead and Co-Produces with Blaise Dolcemaschio. 2Health News:The True 9/11 Hero Story “Color of Honor” Premieres in Germany and Bangladesh: Luciana Lagana Plays the Mother of the Lead and Co-Produces with Blaise Dolcemaschio. 3Health News:LunaDress Provides Professional Tips On Shopping Wedding And Prom Dresses 2Health News:Researchers Take 'First Baby Step' Toward Anti-Aging Drug 2Health News:Researchers Take 'First Baby Step' Toward Anti-Aging Drug 3Health News:Retirement Community Residents Make Impact During Holiday Season 2
... first to tackle different forms of the disease and help ... new vaccine is designed to trigger production of a range ... causing the disease. Scientists created the vaccine by ... types of malaria parasite, which is known to trigger production ...
... A vaccine to prevent anal cancer is safe and effective ... funded in part by the vaccine,s maker. Anal cancer ... sexually transmitted disease in the United States. Anal cancer is ... with HIV. , , Merck,s Gardasil vaccine is already ...
... 11-month-old partnership between UCSF and Pfizer, Inc., aimed at ... selected its first projects for funding and joint development. ... on experimental therapies developed by the UCSF scientists with ... hard-to-treat, often deadly conditions, including lung and prostate cancer. ...
... News) -- Moving to the beat of music actually helps ... Researchers at McMaster University in Canada played a series ... on an electronic drum pad while they listened while the ... whether the final beat was consistent with the preceding rhythm, ...
... WEDNESDAY, Oct. 26 (HealthDay News) -- The genes suspected of ... the developing brain before birth, according to a major genetic ... spotted hundreds of genetic differences between males and females still ... genes involved in the development of the brain, but now ...
... estimate, half of Americans are confronting a civil legal problem at ... advice, or an advocate in civil court, they may lose a ... They may lose out in a divorce, or in a billing ... those services depends not on their need but where they live, ...
Cached Medicine News:Health News:Multiple malaria vaccine offers protection to people most at risk 2Health News:HPV Vaccine Might Help Prevent Anal Cancers: Study 2Health News:UCSF-Pfizer partnership yields projects aimed at clinical trials 2Health News:UCSF-Pfizer partnership yields projects aimed at clinical trials 3Health News:UCSF-Pfizer partnership yields projects aimed at clinical trials 4Health News:Links to Mental Illness Seen in Fetal Brains: Study 2Health News:Access to legal aid depends a lot on where you live, report says 2Health News:Access to legal aid depends a lot on where you live, report says 3
(Date:12/22/2014)... 22, 2014  CytoSorbents Corporation (OTCQB:CTSOD), a critical ... purification technology to help fight deadly inflammation in ... worldwide, today announced the appointment of Dr. ... its Senior Vice President of Clinical Development, effective ... Di Russo is an accomplished pediatric cardiothoracic ...
(Date:12/22/2014)... MEMPHIS, Tenn. , Dec. 22, 2014   ... only automated, no-touch UV disinfection robot, announced today that ... GSA Schedule contract through November 2019.   ... to rapidly engage all levels of government purchasers, including ... facilities, as well as Homeland Security contacts purchasing solutions ...
(Date:12/22/2014)... STOCKHOLM , Dec. 22, 2014 ... Pharmaceuticals, Inc. today announced that the Committee for Medicinal ... Agency (EMA) has adopted a positive opinion for the ... of adult men with Peyronie,s disease with a palpable ... at the start of therapy. The use ...
Breaking Medicine Technology:CytoSorbents Appoints Dr. Gregory B. Di Russo as Senior Vice President of Clinical Development 2CytoSorbents Appoints Dr. Gregory B. Di Russo as Senior Vice President of Clinical Development 3CytoSorbents Appoints Dr. Gregory B. Di Russo as Senior Vice President of Clinical Development 4CytoSorbents Appoints Dr. Gregory B. Di Russo as Senior Vice President of Clinical Development 5TRU-D SmartUVC LLC Awarded General Services Administration Contract to Expand Government Customer Base 2Sobi's Xiapex receives positive opinion by CHMP for the treatment of Peyronie's disease 2Sobi's Xiapex receives positive opinion by CHMP for the treatment of Peyronie's disease 3Sobi's Xiapex receives positive opinion by CHMP for the treatment of Peyronie's disease 4Sobi's Xiapex receives positive opinion by CHMP for the treatment of Peyronie's disease 5Sobi's Xiapex receives positive opinion by CHMP for the treatment of Peyronie's disease 6
... found to be prevalent in cancer patients regardless of nutritional ... at Cancer Treatment Centers of America ... for vitamin D deficiency and aggressive vitamin D repletion should ... (Logo: http://www.newscom.com/cgi-bin/prnh/20090612/CTCALOGO ) , ...
... Jazz Pharmaceuticals, (Nasdaq: JAZZ ) sodium oxybate ... and the core symptoms associated with fibromyalgia, according to Phase ... Sleep Societies meeting in Seattle, WA. These data have ... for use of sodium oxybate in the treatment of fibromyalgia. ...
Cached Medicine Technology:Study Suggests Vitamin D Screening and Appropriate Supplementation Indicated for All Cancer Patients 2Data Suggest Sodium Oxybate Significantly Improves Pain and the Core Symptoms of Fibromyalgia 2Data Suggest Sodium Oxybate Significantly Improves Pain and the Core Symptoms of Fibromyalgia 3Data Suggest Sodium Oxybate Significantly Improves Pain and the Core Symptoms of Fibromyalgia 4Data Suggest Sodium Oxybate Significantly Improves Pain and the Core Symptoms of Fibromyalgia 5
Both versions of the UltraSling II provide immobilization for rotator cuff repairs, capusular shifts, Bankhart repairs, glenohumeral dislocations/subluxation and soft tissue repairs/strains....
Unique V-lock strapping system prevents roll and shifting to provide secure shoulder immobilization...
... Bird and Cronin, Inc. ... of Patient Footwear, Orthopedic ... Care Products. Our products ... quality and available in ...
... Effective spinal bracing is a critical component ... surgical stabilization. The Aspen® Lumbosacral Bracing System™ ... provide a high degree of immobilization, unparalled ... patients . . . even if they ...
Medicine Products: