Navigation Links
Animal research suggests new strategy for treating cocaine addiction
Date:4/6/2008

WINSTON-SALEM, N.C. New research in monkeys suggests the feasibility of treating cocaine addiction with a replacement drug that mimics the effects of cocaine but has less potential for abuse similar to the way nicotine and heroin addictions are treated.

Reporting at the annual meeting of the American Society of Pharmacology and Experimental Therapeutics in San Diego, Calif., scientists from Wake Forest University School of Medicine said treating monkeys with amphetamine significantly reduced their self-administration of cocaine for up to a month.

This suggests the possibility of developing an amphetamine-like drug for treating cocaine addiction, said Paul Czoty, Ph.D., lead author and assistant professor of physiology and pharmacology. The research also demonstrates the usefulness for conducting studies in monkeys to test potential treatments.

Czoty said the quest to develop a treatment for cocaine addiction has been ongoing for decades with little success. While we have medications for heroin and tobacco abuse, there is no FDA-approved treatment for cocaine, he said.

With both heroin and tobacco, there are treatments to replace the addictive drug with a drug that has similar effects on the body, but with less potential for abuse.

With this strategy in mind, clinical researchers have turned to drugs currently available, including amphetamines, said Czoty. While its unlikely that amphetamine itself will turn out to be the best treatment, these drugs allow us to prove the concept of using a replacement drug to combat cocaine addiction.

Amphetamines have been used in clinical studies with some success, said Czoty. His research in monkeys may help identify the best dose and schedule for administering a replacement drug as well as evaluate potential treatment candidates and estimate potential side effects.

For the study, a monkey was taught to press levers multiple times to obtain food or a cocaine injection. With each injection, the number of required lever presses increased so that the animal had to work harder for the cocaine.

This procedure measures the strength of the reinforcing effects of drugs, said Czoty. Each injection requires more and more work and eventually it gets to the point where its not worth it to the monkey because more than 1,000 presses are required.

Access to cocaine was then removed and the monkey was treated intravenously with an amphetamine 24 hours per day. When re-exposed to cocaine one week later, a dramatic decrease in responding for cocaine was observed. They tested three different doses of amphetamine and found that a moderate dose was most effective. Although the treatment also decreased lever-pressing for foodwhich could be predictive of side effects in humans -- this effect disappeared within one week while the effect on responding for cocaine injections persisted for up to one month.

This was a very positive finding exactly what we had hoped to see, said Czoty. Cocaine use was significantly reduced by about 60 percent.

The researchers are currently repeating the study in additional animals. They hope it could eventually lead to identifying a slightly different drug that will obtain the same results as amphetamines.

Czoty said the study is significant because it and other similar studies in monkeys duplicate what has been found in small studies in humans, which suggests that the animal model can be used to test other treatments. The researchers, for example, plan to test topiramate (Topamax), an anti-convulsant drug that is sometimes used to treat epilepsy and may be effective in treating alcoholism.

We have found a model we can use to test new drugs and have an idea of what positive or negative effects would look like, said Czoty.


'/>"/>

Contact: Karen Richardson
krchrdsn@wfubmc.edu
336-716-4453
Wake Forest University Baptist Medical Center
Source:Eurekalert

Related medicine news :

1. Animal Study Links Social Standing With Drug Use Risk
2. Humans have more distinctive hearing than animals, Hebrew U study shows
3. Gamma Secretase Modulators Show Promise in Alzheimers Disease Animal Model Efficacy Studies, According to Research Conducted by TorreyPines Therapeutics
4. Folate scores a win in animal studies: Brief, high doses of B vitamin blunt damage from heart attack
5. Human, animal vaccine development goal of hepatitis E virus research
6. Pain Management For Your Pets, Key Information Every Pet Owner Should Know - Live Webcast to Pet Owners, March 13, 8:00 p.m. to 9:00 p.m. (EDT) Via Morris Animal Foundation
7. Pain Management For Pets, Key Strategies For Veterinarians - Live Webcast to Veterinarians, March 13, 7:00 p.m. to 8:00 p.m. (EDT) Via Morris Animal Foundation
8. Researchers create first chikungunya animal model
9. Animal Planet Pet Video to Provide 2 Million Free Training DVDs to New Pet Parents of Adopted Shelter Dogs and Cats
10. U.S. Seeks to Limit Animal Testing of Toxic Chemicals
11. Chicago Tribune Does Story on Canine Cancer, Morris Animal Foundation (MAF) Effort to Find a Cure - MAF Can Provide Information - Local Angles for a Feature Story
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/20/2017)... ... ... Pastor and Overseer at The House of Yahweh has posted a new publication this week ... is a time like no other and society needs to understand the only way to ... not want to sound like an old bible beater because religion has a bad rap ...
(Date:1/20/2017)... ... 2017 , ... Bionic Sports Nutrition LLC, an American company devoted to developing ... successful January ECRM Trade Show in Hilton Head, SC. , Bionic Sports Nutrition ... provide its products to all clients at reasonable prices. At the ECRM trade show, ...
(Date:1/20/2017)... ... 2017 , ... International Protein, a company based out of Australia that focuses ... January ECRM trade show in Hilton Head, SC. , International Protein was founded ... a line of products that would elevate her fitness regime. At this ECRM trade ...
(Date:1/20/2017)... ... January 20, 2017 , ... Vitamin ... alternative VW+ 002. The drinks have been produced in collaboration with Zlatan Ibrahimovic ... during your workout. , After a successful launch in Sweden last year, the ...
(Date:1/20/2017)... ... January 20, 2017 , ... “Code Word: Chocolate Biscuit”: a biographical account following a ... Biscuit” is the creation of published author, Marlyn Ivey, born in Lynn Haven, Florida and ... to school and at 19 years of age, he joined the Navy and got married ...
Breaking Medicine News(10 mins):
(Date:1/19/2017)... 2017  Stealth BioTherapeutics Inc. ( Stealth ), a ... today announced new additions to its senior leadership team: ... Officer, and Daniel Geffken as interim Chief ... Carr , Pharm.D. has been promoted to Chief Clinical ... welcome Doug and Daniel to our management team, as ...
(Date:1/19/2017)... January 19, 2017 ... Oncology & Haematology, 2016;12(Suppl 2):3-8; http://www.touchoncology.com/articles/optimising-clinical-outcomes-gastrointestinal-cancers-through-inhibiting-angiogenesis-and ... ... Published recently in a supplement to ... from touchONCOLOGY, an article by James Gilbart ...
(Date:1/19/2017)... 2017 Pfizer joins Astex, ... Therapeutics Consortium   Major research investment ...   The Milner Therapeutics Institute ... as a partner to the Milner Therapeutics Consortium. Pfizer ... efficient transfer of materials between industry and academia and ...
Breaking Medicine Technology: